Microfluidic particle separator utilizing sheathless elasto-inertial focusing

Chemical Engineering Science

Volumn 126, Issue , 2015, Pages 237-243

  Ahn, Sung Won ^a   Lee, Sung Sik ^b   Lee, Seong Jae ^c   Kim, Ju Min ^a  

^a Ajou University   (South Korea)

^b ETH ZURICH   (Switzerland)

^c Suwon University   (South Korea)

Author keywords

Focusing; Microchannel Flow; Particle Separation; Sheathless Elasto Inertial; Viscoelastic Flow

Indexed keywords

ELECTRIC FIELDS; FLOW RATE; FOCUSING; MICROCHANNELS; PARTICLE SEPARATORS; SEPARATORS; SHEAR FLOW; SHEAR THINNING; VISCOELASTICITY;

BIOLOGICAL APPLICATIONS; MICROCHANNEL FLOW; PARTICLE CONCENTRATIONS; PARTICLE SEPARATION; PARTICLE-PARTICLE INTERACTIONS; SHEAR-THINNING BEHAVIOR; SHEATHLESS ELASTO-INERTIAL; VISCOELASTIC FLOWS;

MICROFLUIDICS;

EID: 84920133208     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2014.12.019     Document Type: Article

References (27)

1. Bird R.B., Armstrong R.C., Hassager O. Dynamics of Polymeric Liquids 1987, Wiley Interscience, New York.
2. D'Avino G., Romeo G., Villone M.M., Greco F., Netti P.A., Maffettone P.L. Single line particle focusing induced by viscoelasticity of the suspending liquid: theory, experiments and simulations to design a micropipe flow-focuser. Lab Chip 2012, 12:1638-1645.
3. Del Giudice F., Romeo G., D'Avino G., Greco F., Netti P.A., Maffettone P.L. Particle alignment in a viscoelastic liquid flowing in a square-shaped microchannel. Lab Chip 2013, 13:4263-4271.
4. Di Carlo D., Edd J.F., Irimia D., Tompkins R.G., Toner M. Equilibrium separation and filtration of particles using differential inertial focusing. Anal. Chem. 2008, 80:2204-2211.
5. Giddings J.C. Field-flow fractionation: analysis of macromolecular, colloidal, and particulate materials. Science 1993, 260:1456-1465.
6. Gossett D.R., Weaver W.M., Mach A.J., Hur S.C., Tse H.T., Lee W., Amini H., Di Carlo D. Label-free cell separation and sorting in microfluidic systems. Anal. Bioanal. Chem. 2010, 397:3249-3267.
7. Ho B.P., Leal L.G. Migration of rigid spheres in a 2-dimensional unidirectional shear-flow of a 2nd-order fluid. J. Fluid Mech. 1976, 76:783-799.
8. Kang K., Lee S.S., Hyun K., Lee S.J., Kim J.M. DNA-based highly tunable particle focuser. Nat. Commun 2013, 4:2567.
9. Karimi A., Yazdi S., Ardekani A.M. Hydrodynamic mechanisms of cell and particle trapping in microfluidics. Biomicrofluidics 2013, 7:021501.
10. Karnis A., Mason S.G., Goldsmith H.L. Axial migration of particles in Poiseuille flow. Nature 1963, 200:159-160.
11. Larson R.G. The rheology of dilute solutions of flexible polymers: progress and problems. J. Rheol. 2005, 49:1-70.
12. Lenshof A., Laurell T. Continuous separation of cells and particles in microfluidic systems. Chem. Soc. Rev. 2010, 39:1203-1217.
13. Leshansky A.M., Bransky A., Korin N., Dinnar U. Tunable nonlinear viscoelastic "focusing" in a microfluidic device. Phys. Rev. Lett. 2007, 98:234501.
14. Lim E.J., Ober T.J., Edd J.F., Desai S.P., Neal D., Bong K.W., Doyle P.S., McKinley G.H., Toner M. Inertio-elastic focusing of bioparticles in microchannels at high throughput. Nat. Commun 2014, 5:4120.
15. Mao X., Waldeisen J.R., Huang T.J. "Microfluidic drifting"-implementing three-dimensional hydrodynamic focusing with a single-layer planar microfluidic device. Lab Chip 2007, 7:1260-1262.
16. Nam J., Lim H., Kim D., Jung H., Shin S. Continuous separation of microparticles in a microfluidic channel via the elasto-inertial effect of non-Newtonian fluid. Lab Chip 2012, 12:1347-1354.
17. Pamme N. Continuous flow separations in microfluidic devices. Lab Chip 2007, 7:1644-1659.
18. Rodd L.E., Cooper-White J.J., Boger D.V., McKinley G.H. Role of the elasticity number in the entry flow of dilute polymer solutions in micro-fabricated contraction geometries. J. Non-Newt. Fluid Mech 2007, 143:170-191.
19. Rodd L.E., Scott T.P., Boger D.V., Cooper-White J.J., McKinley G.H. The inertio-elastic planar entry flow of low-viscosity elastic fluids in micro-fabricated geometries. J. Non-Newt. Fluid Mech 2005, 129:1-22.
20. Romeo G., D'Avino G., Greco F., Netti P.A., Maffettone P.L. Viscoelastic flow-focusing in microchannels: scaling properties of the particle radial distributions. Lab Chip 2013, 13:2802-2807.
21. Seo K.W., Byeon H.J., Huh H.K., Lee S.J. Particle migration and single-line particle focusing in microscale pipe flow of viscoelastic fluids. RSC Adv 2014, 4:3512-3520.
22. Tehrani M.A. An experimental study of particle migration in pipe flow of viscoelastic fluids. J. Rheol. 1996, 40:1057-1077.
23. Tirtaatmadja V., McKinley G.H., Cooper-White J.J. Drop formation and breakup of low viscosity elastic fluids: effects of molecular weight and concentration. Phys. Fluids 2006, 18:043101.
24. Xia Y., Whitesides G.M. Soft lithography. Angew. Chem. Int. Edit. 1998, 37:550-575.
25. Xuan X.C., Zhu J.J., Church C. Particle focusing in microfluidic devices. Microfluid Nanofluid 2010, 9:1-16.
26. Yang S., Kim J.Y., Lee S.J., Lee S.S., Kim J.M. Sheathless elasto-inertial particle focusing and continuous separation in a straight rectangular microchannel. Lab Chip 2011, 11:266-273.
27. Yang S., Lee S.S., Ahn S.W., Kang K., Shim W., Lee G., Hyun K., Kim J.M. Deformability-selective particle entrainment and separation in a rectangular microchannel using medium viscoelasticity. Soft Matter 2012, 8:5011-5019.