Label-free cell separation and sorting in microfluidic systems

Analytical and Bioanalytical Chemistry

Volumn 397, Issue 8, 2010, Pages 3249-3267

  Gossett, Daniel R ^a,b   Weaver, Westbrook M ^a,b   MacH, Albert J ^a,b   Hur, Soojung Claire ^a,b   Tse, Henry Tat Kwong ^a,b   Lee, Wonhee ^a,b   Amini, Hamed ^a,b   Di Carlo, Dino ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA NANOSYSTEMS INSTITUTE   (United States)

Author keywords

Bioanalytical methods; Biochips; Cell systems; Field flow fractionation; High throughput screening; Instrumentation; Microfabrication; Microfluidics; Separations; Single cell analysis

Indexed keywords

BIOANALYTICAL METHODS; CELL SYSTEMS; FIELD FLOW FRACTIONATION; HIGH-THROUGHPUT SCREENING; INSTRUMENTATION; SINGLECELL ANALYSIS;

BIOASSAY; BIOCHIPS; BIOPOLYMERS; CELL CULTURE; CELL PROLIFERATION; ELECTRIC PROPERTIES; FLUIDIC DEVICES; INSTRUMENTS; LIQUID CHROMATOGRAPHY; MICROANALYSIS; MICROFABRICATION; MICROMACHINING;

MICROFLUIDICS;

ANIMAL; CELL; CELL SEPARATION; CHEMISTRY; CYTOLOGY; HUMAN; INSTRUMENTATION; METHODOLOGY; MICROFLUIDIC ANALYSIS; REVIEW; CELLS; DEVICES; PROCEDURES;

ANIMALS; CELL SEPARATION; CELLS; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 77956061536     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-3721-9     Document Type: Review

References (122)

1. J Li Z Zhang J Rosenzweig YY Wang DW Chan 2002 Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer Clin Chem 48 1296 1304
2. J Villanueva DR Shaffer J Philip CA Chaparro H Erdjument-Bromage AB Olshen M Fleisher H Lilja E Brogi J Boyd M Sanchez-Carbayo EC Holland C Cordon-Cardo HI Scher P Tempst 2006 Differential exoprotease activities confer tumor-specific serum peptidome patterns J Clin Invest 116 271 284
3. HF Bunn 1997 Pathogenesis and treatment of sickle cell disease N Engl J Med 337 762 769
4. M Toner D Irimia 2005 Blood-on-a-chip Annu Rev Biomed Eng 7 77 103
5. M Cristofanilli GT Budd MJ Ellis A Stopeck J Matera MC Miller JM Reuben GV Doyle WJ Allard LW Terstappen DF Hayes 2004 Circulating tumor cells, disease progression, and survival in metastatic breast cancer N Engl J Med 351 781 791
6. K Krabchi F Gros-Louis J Yan M Bronsard J Massé JC Forest R Drouin 2001 Quantification of all fetal nucleated cells in maternal blood between the 18th and 22nd weeks of pregnancy using molecular cytogenetic techniques Clin Genet 60 145 150
7. P Sethu A Sin M Toner 2006 Microfluidic diffusive filter for apheresis (leukapheresis) Lab Chip 6 83 89
8. B Roda P Reschiglian A Zattoni F Alviano G Lanzoni R Costa AD Di Carlo C Marchionni M Franchina L Bonsi GP Bagnara 2009 A tag-less method of sorting stem cells from clinical specimens and separating mesenchymal from epithelial progenitor cells Cytometry B Clin Cytom 76B 285 290
9. S Choi S Song C Choi J Park 2009 Microfluidic self-sorting of mammalian cells to achieve cell cycle synchrony by hydrophoresis Anal Chem 81 1964 1968
10. J El-Ali PK Sorger KF Jensen 2006 Cells on chips Nature 442 403 411
11. Shapiro HM (2003) Practical flow cytometry. Wiley-Liss, New York
12. S Miltenyi W Müller W Weichel A Radbruch 1990 High gradient magnetic cell separation with MACS Cytometry 11 231 238
13. D Després T Flohr M Uppenkamp M Baldus M Hoffmann C Huber HG Derigs 2000 CD34+ cell enrichment for autologous peripheral blood stem cell transplantation by use of the CliniMACs device J Hematother Stem Cell Res 9 557 564
14. AL Allan SA Vantyghem AB Tuck AF Chambers IH Chin-Yee M Keeney 2005 Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometry Cytometry A 65 4 14
15. G Hager DC Tong I Schiebel GA Rezniczek R Watrowski P Speiser R Zeillinger 2005 The use of a panel of monoclonal antibodies to enrich circulating breast cancer cells facilitates their detection Gynecol Oncol 98 211 216
16. A Kumar A Bhardwaj 2008 Methods in cell separation for biomedical application: cryogels as a new tool Biomed Mater 3 034008
17. D English BR Andersen 1974 Single-step separation of red blood cells, granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque J Immunol Methods 5 249 252
18. J Lundahl G Halldén M Hallgren CM Sköld J Hed 1995 Altered expression of CD11b/CD18 and CD62L on human monocytes after cell preparation procedures J Immunol Methods 180 93 100
19. S Fukuda GW Schmid-Schonbein 2002 Centrifugation attenuates the fluid shear response of circulating leukocytes J Leukoc Biol 72 133 139
20. J SooHoo G Walker 2009 Microfluidic aqueous two phase system for leukocyte concentration from whole blood Biomed Microdevices 11 323 329
21. E Sollier H Rostaing P Pouteau Y Fouillet J Achard 2009 Chemical: passive microfluidic devices for plasma extraction from whole human blood Sens Actuators B Chem 141 617 624
22. GM Whitesides 2006 The origins and the future of microfluidics Nature 442 368 373
23. TM Squires SR Quake 2005 Microfluidics: fluid physics at the nanoliter scale Rev Mod Phys 77 977
24. N Pamme 2007 Continuous flow separations in microfluidic devices Lab Chip 7 1644 1659
25. H Tsutsui C Ho 2009 Cell separation by non-inertial force fields in microfluidic systems Mech Res Commun 36 92 103
26. P Chen X Feng W Du B Liu 2008 Microfluidic chips for cell sorting Front Biosci 13 2464 2483
27. A Lenshof T Laurell 2010 Continuous separation of cells and particles in microfluidic systems Chem Soc Rev 39 1203 1217
28. H Ji V Samper Y Chen C Heng T Lim L Yobas 2008 Silicon-based microfilters for whole blood cell separation Biomed Microdevices 10 251 257
29. JP Brody TD Osborn FK Forster P Yager 1996 A planar microfabricated fluid filter Sens Actuators A Phys 54 704 708
30. TA Crowley V Pizziconi 2005 Isolation of plasma from whole blood using planar microfilters for lab-on-a-chip applications Lab Chip 5 922 929
31. V VanDelinder A Groisman 2006 Separation of plasma from whole human blood in a continuous cross-flow in a molded microfluidic device Anal Chem 78 3765 3771
32. X Chen DF Cui CC Liu H Li 2008 Microfluidic chip for blood cell separation and collection based on crossflow filtration Sens Actuators B Chem 130 216 221
33. H Mohamed JN Turner M Caggana 2007 Biochip for separating fetal cells from maternal circulation J Chromatogr A 1162 187 192
34. C Jönsson M Aronsson G Rundström C Pettersson I Mendel-Hartvig J Bakker E Martinsson B Liedberg B MacCraith O Öhman J Melin 2008 Silane-dextran chemistry on lateral flow polymer chips for immunoassays Lab Chip 8 1191
35. X Chen D Cui L Zhang 2009 Isolation of plasma from whole blood using a microfludic chip in a continuous cross-flow Chin Sci Bull 54 324 327
36. P Sethu A Sin M Toner 2006 Microfluidic diffusive filter for apheresis (leukapheresis) Lab Chip 6 83 89
37. V VanDelinder A Groisman 2007 Perfusion in microfluidic cross-flow: separation of white blood cells from whole blood and exchange of medium in a continuous flow Anal Chem 79 2023 2030
38. S Murthy P Sethu G Vunjak-Novakovic M Toner M Radisic 2006 Size-based microfluidic enrichment of neonatal rat cardiac cell populations Biomed Microdevices 8 231 237
39. X Chen D Cui C Liu H Li J Chen 2007 Continuous flow microfluidic device for cell separation, cell lysis and DNA purification Anal Chim Acta 584 237 243
40. S Zheng H Lin J Liu M Balic R Datar RJ Cote Y Tai 2007 Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells J Chromatogr A 1162 154 161
41. JS Kuo Y Zhao PG Schiro L Ng DSW Lim JP Shelby DT Chiu 2010 Deformability considerations in filtration of biological cells Lab Chip 10.1039/b922301k
42. M Yamada M Nakashima M Seki 2004 Pinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel Anal Chem 76 5465 5471
43. J Takagi M Yamada M Yasuda M Seki 2005 Continuous particle separation in a microchannel having asymmetrically arranged multiple branches Lab Chip 5 778
44. M Yamada M Seki 2005 Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics Lab Chip 5 1233 1239
45. M Yamada K Kano Y Tsuda J Kobayashi M Yamato M Seki T Okano 2007 Microfluidic devices for size-dependent separation of liver cells Biomed Microdevices 9 637 645
46. LR Huang EC Cox RH Austin JC Sturm 2004 Continuous particle separation through deterministic lateral displacement Science 304 987 990
47. DW Inglis JA Davis RH Austin JC Sturm 2006 Critical particle size for fractionation by deterministic lateral displacement Lab Chip 6 655 658
48. S Zheng Y Tai H Kasdan 2005 A micro device for separation of erythrocytes and leukocytes in human blood Conf Proc IEEE Eng Med Biol Soc 1 1024 1027
49. JA Davis DW Inglis KJ Morton DA Lawrence LR Huang SY Chou JC Sturm RH Austin 2006 Deterministic hydrodynamics: taking blood apart Proc Natl Acad Sci U S A 103 14779 14784
50. DW Inglis JA Davis TJ Zieziulewicz DA Lawrence RH Austin JC Sturm 2008 Determining blood cell size using microfluidic hydrodynamics J Immunol Methods 329 151 156
51. KJ Morton K Loutherback DW Inglis OK Tsui JC Sturm SY Chou RH Austin 2008 Crossing microfluidic streamlines to lyse, label and wash cells Lab Chip 8 1448 1453
52. DW Inglis 2009 Efficient microfluidic particle separation arrays Appl Phys Lett 94 013510 013513
53. BR Long M Heller JP Beech H Linke H Bruus JO Tegenfeldt 2008 Multidirectional sorting modes in deterministic lateral displacement devices Phys Rev E 78 046304 046309
54. R Huang TA Barber MA Schmidt RG Tompkins M Toner DW Bianchi R Kapur WL Flejter 2008 A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women Prenat Diagn 28 892 899
55. JC Giddings 1993 Field-flow fractionation: analysis of macromolecular, colloidal, and particulate materials Science 260 1456 1465
56. JC Giddings 1985 A System based on split-flow lateral-transport thin (splitt) separation cells for rapid and continuous particle fractionation Sep Sci Technol 20 749
57. J Vykoukal DM Vykoukal S Freyberg EU Alt PRC Gascoyne 2008 Enrichment of putative stem cells from adipose tissue using dielectrophoretic field-flow fractionation Lab Chip 8 1386 1393
58. B Roda A Zattoni P Reschiglian MH Moon M Mirasoli E Michelini A Roda 2009 Field-flow fractionation in bioanalysis: a review of recent trends Anal Chim Acta 635 132 143
59. PB Howell Jr DR Mott S Fertig CR Kaplan JP Golden ES Oran FS Ligler 2005 A microfluidic mixer with grooves placed on the top and bottom of the channel Lab Chip 5 524
60. NS Lynn DS Dandy 2007 Geometrical optimization of helical flow in grooved micromixers Lab Chip 7 580 587
61. S Choi J Park 2007 Continuous hydrophoretic separation and sizing of microparticles using slanted obstacles in a microchannel Lab Chip 7 890 897
62. C Hsu D Di Carlo C Chen D Irimia M Toner 2008 Microvortex for focusing, guiding and sorting of particles Lab Chip 8 2128 2134
63. D Di Carlo 2009 Inertial microfluidics Lab Chip 9 3038 3046
64. G Segré A Silberberg 1961 Radial particle displacements in poiseuille flow of suspensions Nature 189 209 210
65. D Di Carlo D Irimia RG Tompkins M Toner 2007 Continuous inertial focusing, ordering, and separation of particles in microchannels Proc Natl Acad Sci U S A 104 18892 18897
66. DR Gossett D Di Carlo 2009 Particle focusing mechanisms in curving confined flows Anal Chem 81 8459 8465
67. SA Berger L Talbot LS Yao 1983 Flow in curved pipes Ann Rev Fluid Mech 15 461 512
68. AP Sudarsan VM Ugaz 2006 Multivortex micromixing Proc Natl Acad Sci U S A 103 7228 7233
69. J Seo MH Lean A Kole 2007 Membrane-free microfiltration by asymmetric inertial migration Appl Phys Lett 91 033901 033903
70. D Di Carlo JF Edd D Irimia RG Tompkins M Toner 2008 Equilibrium separation and filtration of particles using differential inertial focusing Anal Chem 80 2204 2211
71. SS Kuntaegowdanahalli AAS Bhagat G Kumar I Papautsky 2009 Inertial microfluidics for continuous particle separation in spiral microchannels Lab Chip 9 2973 2980
72. Z Wu B Willing J Bjerketorp JK Jansson K Hjort 2009 Soft inertial microfluidics for high throughput separation of bacteria from human blood cells Lab Chip 9 1193 1199
73. SC Hur HTK Tse D Di Carlo 2010 Sheathless inertial cell ordering for extreme throughput flow cytometry Lab Chip 10 274 280
74. D Huh JH Bahng Y Ling H Wei OD Kripfgans JB Fowlkes JB Grotberg S Takayama 2007 Gravity-driven microfluidic particle sorting device with hydrodynamic separation amplification Anal Chem 79 1369 1376
75. SS Shevkoplyas T Yoshida LL Munn MW Bitensky 2005 Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device Anal Chem 77 933 937
76. RD Jäggi R Sandoz CS Effenhauser 2006 Microfluidic depletion of red blood cells from whole blood in high-aspect-ratio microchannels Microfluid Nanofluid 3 47 53
77. M Faivre M Abkarian K Bickraj HA Stone 2006 Geometrical focusing of cells in a microfluidic device: an approach to separate blood plasma Biorheology 43 147 159
78. S Yang A Undar JD Zahn 2006 A microfluidic device for continuous, real time blood plasma separation Lab Chip 6 871
79. M Zborowski GR Ostera LR Moore S Milliron JJ Chalmers AN Schechter 2003 Red blood cell magnetophoresis Biophys J 84 2638 2645
80. K Han AB Frazier 2004 Continuous magnetophoretic separation of blood cells in microdevice format J Appl Phys 96 5797 5802
81. K Han AB Frazier 2005 Diamagnetic capture mode magnetophoretic microseparator for blood cells J Microelectromech Syst 14 1422 1431
82. K Han AB Frazier 2006 Paramagnetic capture mode magnetophoretic microseparator for high efficiency blood cell separations Lab Chip 6 265 273
83. EP Furlani 2007 Magnetophoretic separation of blood cells at the microscale J Phys D Appl Phys 40 1313 1319
84. J Jung K Han 2008 Lateral-driven continuous magnetophoretic separation of blood cells Appl Phys Lett 93 223902 223903
85. M Yamada V Kasim M Nakashima J Edahiro M Seki 2004 Continuous cell partitioning using an aqueous two-phase flow system in microfluidic devices Biotechnol Bioeng 88 489 494
86. K Nam W Chang H Hong S Lim D Kim Y Koo 2005 Continuous-flow fractionation of animal cells in microfluidic device using aqueous two-phase extraction Biomed Microdevices 7 189 195
87. M Wiklund HM Hertz 2006 Ultrasonic enhancement of bead-based bioaffinity assays Lab Chip 6 1279 1292
88. T Laurell F Petersson A Nilsson 2007 Chip integrated strategies for acoustic separation and manipulation of cells and particles Chem Soc Rev 36 492 506
89. F Petersson A Nilsson C Holm H Jonsson T Laurell 2005 Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces Lab Chip 5 20 22
90. F Petersson A Nilsson C Holm H Jonsson T Laurell 2004 Separation of lipids from blood utilizing ultrasonic standing waves in microfluidic channels Analyst 129 938 943
91. A Lenshof A Ahmad-Tajudin K Jaras A Sward-Nilsson L Aberg G Marko-Varga J Malm H Lilja T Laurell 2009 Acoustic whole blood plasmapheresis chip for prostate specific antigen microarray diagnostics Anal Chem 81 6030 6037
92. S Kapishnikov V Kantsler V Steinberg 2006 Continuous particle size separation and size sorting using ultrasound in a microchannel J Stat Mech Theory Exp 2006 P01012
93. JJ Hawkes WT Coakley 2001 Force field particle filter, combining ultrasound standing waves and laminar flow Sens Actuators B Chem 75 213 222
94. S Gupta DL Feke I Manas-Zloczower 1995 Fractionation of mixed particulate solids according to compressibility using ultrasonic standing wave fields Chem Eng Sci 50 3275 3284
95. F Petersson L Aberg A Sward-Nilsson T Laurell 2007 Free flow acoustophoresis: microfluidic-based mode of particle and cell separation Anal Chem 79 5117 5123
96. X Wang Y Huang FF Becker PRC Gascoyne 1994 A unified theory of dielectrophoresis and travelling wave dielectrophoresis J Phys D Appl Phys 27 1571 1574
97. PRC Gascoyne J Vykoukal 2002 Particle separation by dielectrophoresis Electrophoresis 23 1973 1983
98. MD Vahey J Voldman 2008 An equilibrium method for continuous-flow cell sorting using dielectrophoresis Anal Chem 80 3135 3143
99. X Wang J Yang PRC Gascoyne 1999 Role of peroxide in AC electrical field exposure effects on Friend murine erythroleukemia cells during dielectrophoretic manipulations Biochim Biophys Acta 1426 53 68
100. NG Green A Ramos H Morgan 2000 Ac electrokinetics: a survey of sub-micrometre particle dynamics J Phys D Appl Phys 33 632 641
101. A Ramos H Morgan NG Green A Castellanos 1998 Ac electrokinetics: a review of forces in microelectrode structures J Phys D Appl Phys 31 2338 2353
102. Z Gagnon H Chang 2005 Aligning fast alternating current electroosmotic flow fields and characteristic frequencies with dielectrophoretic traps to achieve rapid bacteria detection Electrophoresis 26 3725 3737
103. WM Arnold HP Schwan U Zimmermann 1987 Surface conductance and other properties of latex particles measured by electrorotation J Phys Chem 91 5093 5098
104. DF Chen H Du WH Li 2006 A 3D paired microelectrode array for accumulation and separation of microparticles J Micromech Microeng 16 1162 1169
105. I Cheng H Chang D Hou H Chang 2007 An integrated dielectrophoretic chip for continuous bioparticle filtering, focusing, sorting, trapping, and detecting Biomicrofluidics 1 021503
106. H Cui J Voldman X He K Lim 2009 Separation of particles by pulsed dielectrophoresis Lab Chip 9 2306 2312
107. EB Cummings AK Singh 2003 Dielectrophoresis in microchips containing arrays of insulating posts: theoretical and experimental results Anal Chem 75 4724 4731
108. MP Hughes R Pethig X Wang 1996 Dielectrophoretic forces on particles in travelling electric fields J Phys D Appl Phys 29 474 482
109. H Morgan AG Izquierdo D Bakewell NG Green A Ramos 2001 The dielectrophoretic and travelling wave forces generated by interdigitated electrode arrays: analytical solution using Fourier series J Phys D Appl Phys 34 1553 1561
110. E Liang RL Smith DS Clague 2004 Dielectrophoretic manipulation of finite sized species and the importance of the quadrupolar contribution Phys Rev E 70 066617
111. T Sun H Morgan NG Green 2007 Analytical solutions of ac electrokinetics in interdigitated electrode arrays: electric field, dielectrophoretic and traveling-wave dielectrophoretic forces Phys Rev E 76 046610 046618
112. I Cheng VE Froude Y Zhu H Chang H Chang 2009 A continuous high-throughput bioparticle sorter based on 3D traveling-wave dielectrophoresis Lab Chip 9 3193 3201
113. Y Huang S Joo M Duhon M Heller B Wallace X Xu 2002 Dielectrophoretic cell separation and gene expression profiling on microelectronic chip arrays Anal Chem 74 3362 3371
114. DM Vykoukal PRC Gascoyne J Vykoukal 2009 Dielectric characterization of complete mononuclear and polymorphonuclear blood cell subpopulations for label-free discrimination Integr Biol 1 477 484
115. JE Gordon Z Gagnon H Chang 2007 Dielectrophoretic discrimination of bovine red blood cell starvation age by buffer selection and membrane cross-linking Biomicrofluidics 1 044102 044105
116. K Han S Han AB Frazier 2009 Lateral displacement as a function of particle size using a piecewise curved planar interdigitated electrode array Lab Chip 9 2958 2964
117. PY Chiou AT Ohta MC Wu 2005 Massively parallel manipulation of single cells and microparticles using optical images Nature 436 370 372
118. A Ohta P Chiou H Phan S Sherwood J Yang A Lau H Hsu A Jamshidi M Wu 2007 Optically controlled cell discrimination and trapping using optoelectronic tweezers IEEE J Sel Top Quantum Electron 13 235 243
119. GJ Shah AT Ohta EP Chiou MC Wu C Kim 2009 EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis Lab Chip 9 1732 1739
120. MP MacDonald GC Spalding K Dholakia 2003 Microfluidic sorting in an optical lattice Nature 426 421 424
121. G Milne D Rhodes M MacDonald K Dholakia 2007 Fractionation of polydisperse colloid with acousto-optically generated potential energy landscapes Opt Lett 32 1144 1146
122. S Choi S Song C Choi J Park 2007 Continuous blood cell separation by hydrophoretic filtration Lab Chip 7 1532 1538