Treatment of chronic experimental autoimmune encephalomyelitis with epigallocatechin-3-gallate and glatiramer acetate alters expression of heme-oxygenase-1

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Janssen, Antonia ^a,b   Fiebiger, Sebastian ^a,b   Bros, Helena ^a,b   Hertwig, Laura ^a,b   Romero Suarez, Silvina ^a,b   Hamann, Isabell ^a,b   Chanvillard, Coralie ^a,b   Bellmann Strobl, Judith ^a,b   Paul, Friedemann ^a,b   Millward, Jason M ^a,b   Infante Duarte, Carmen ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPIGALLOCATECHIN GALLATE; GLATIRAMER; HEME OXYGENASE 1; CATECHIN; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; AXONAL INJURY; CONTROLLED STUDY; DEMYELINATION; DOWN REGULATION; DRUG MECHANISM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE EXPRESSION REGULATION; IRON CHELATION; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; SINGLE DRUG DOSE; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; AXON; BIOSYNTHESIS; CHRONIC DISEASE; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYMOLOGY; MYELIN SHEATH; OXIDATION REDUCTION REACTION; PATHOLOGY;

MUS;

ANIMALS; AXONS; CATECHIN; CHRONIC DISEASE; DOWN-REGULATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLATIRAMER ACETATE; HEME OXYGENASE-1; MEMBRANE PROTEINS; MICE; MYELIN SHEATH; OXIDATION-REDUCTION;

EID: 84937616610     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130251     Document Type: Article

References (35)

1. Infante-Duarte C, Waiczies S, Wuerfel J, Zipp F (2008) New developments in understanding and treating neuroinflammation. J Mol Med (Berl) 86: 975-985. doi: 10.1007/s00109-007-0292-0 PMID: 18196212
2. Bailey SL, Schreiner B, McMahon EJ, Miller SD (2007) CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE. Nat Immunol 8: 172-180. PMID: 17206145
3. Bjartmar C, Trapp BD (2001) Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr Opin Neurol 14: 271-278. PMID: 11371748
4. Rovaris M, Confavreux C, Furlan R, Kappos L, Comi G, Filippi M (2006) Secondary progressive multiple sclerosis: current knowledge and future challenges. Lancet Neurol 5: 343-354. PMID: 16545751
5. Forge JK, Pedchenko TV, LeVine SM (1998) Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis. Life Sci 63: 2271-2284. PMID: 9870713
6. Levine SM, Chakrabarty A (2004) The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Ann N Y Acad Sci 1012: 252-266. PMID: 15105271
7. di Penta A, Moreno B, Reix S, Fernandez-Diez B, Villanueva M, Errea O, et al. (2013) Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation. PLoS ONE 8: e54722. doi: 10.1371/journal.pone.0054722 PMID: 23431360
8. Aktas O, Prozorovski T, Smorodchenko A, Savaskan NE, Lauster R, Kloetzel PM, et al. (2004) Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J Immunol 173: 5794-5800. PMID: 15494532
9. Schroeder EK, Kelsey NA, Doyle J, Breed E, Bouchard RJ, Loucks FA, et al. (2009) Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid Redox Signal 11: 469-480. doi: 10. 1089/ARS.2008.2215 PMID: 18754708
10. Weinreb O, Amit T, Mandel S, Youdim MB (2009) Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties. Genes Nutr 4: 283-296. doi: 10.1007/s12263-009-0143-4 PMID: 19756809
11. Mahler A, Mandel S, Lorenz M, Ruegg U, Wanker EE, Boschmann M, et al. (2013) Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases? EPMA J 4: 5. doi: 10.1186/1878-5085-4-5 PMID: 23418936
12. Wang J, Ren Z, Xu Y, Xiao S, Meydani SN, Wu D (2012) Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsets. Am J Pathol 180: 221-234. doi: 10.1016/j.ajpath.2011.09.007 PMID: 22056360
13. Aharoni R, Eilam R, Domev H, Labunskay G, Sela M, Arnon R (2005) The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice. Proc Natl Acad Sci U S A 102: 19045-19050. PMID: 16365293
14. Khan O, Shen Y, Caon C, Bao F, Ching W, Reznar M, et al. (2005) Axonal metabolic recovery and potential neuroprotective effect of glatiramer acetate in relapsing-remitting multiple sclerosis. Mult Scler 11: 646-651. PMID: 16320723
15. Aharoni R, Vainshtein A, Stock A, Eilam R, From R, Shinder V, et al. (2011) Distinct pathological patterns in relapsing-remitting and chronic models of experimental autoimmune enchephalomyelitis and the neuroprotective effect of glatiramer acetate. J Autoimmun 37: 228-241. doi: 10.1016/j.jaut.2011.06.003 PMID: 21752599
16. Maier K, Kuhnert AV, Taheri N, Sattler MB, Storch MK, Williams SK, et al. (2006) Effects of glatiramer acetate and interferon-beta on neurodegeneration in a model of multiple sclerosis: a comparative study. Am J Pathol 169: 1353-1364. PMID: 17003491
17. Scorisa JM, Zanon RG, Freria CM, de Oliveira AL (2009) Glatiramer acetate positively influences spinal motoneuron survival and synaptic plasticity after ventral root avulsion. Neurosci Lett 451: 34-39. doi: 10.1016/j.neulet.2008.12.017 PMID: 19103252
18. Herges K, Millward JM, Hentschel N, Infante-Duarte C, Aktas O, Zipp F (2011) Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation. PLoS ONE 6: e25456. doi: 10.1371/journal.pone.0025456 PMID: 22022398
19. Fiebiger SM, Bros H, Grobosch T, Janssen A, Chanvillard C, Paul F, et al. (2013) The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse. J Neuroimmunol 262: 66-71. doi: 10.1016/j.jneuroim.2013.07.002 PMID: 23871488
20. Riek K, Millward J, Hamann I, S. M, Pfueller C, Paul F, et al. (2012) Magnetic resonance elastography reveals altered brain viscoelasticity in experimental autoimmune encephalomyelitis. Neuroimage 1: 81-90. doi: 10.1016/j.nicl.2012.09.003 PMID: 24179740
21. Millward JM, Schnorr J, Taupitz M, Wagner S, Wuerfel JT, Infante-Duarte C (2013) Iron oxide magnetic nanoparticles highlight early involvement of the choroid plexus in central nervous system inflammation. ASN Neuro 5: e00110. PMID: 23452162
22. Riemer J, Hoepken HH, Czerwinska H, Robinson SR, Dringen R (2004) Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells. Anal Biochem 331: 370-375. PMID: 15265744
23. Wang J, Pae M, Meydani SN, Wu D (2013) Green tea epigallocatechin-3-gallate modulates differentiation of naive CD4(+) T cells into specific lineage effector cells. J Mol Med (Berl) 91: 485-495. doi: 10.1007/s00109-012-0964-2 PMID: 23064699
24. van Horssen J, Schreibelt G, Drexhage J, Hazes T, Dijkstra CD, van der Valk P, et al. (2008) Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression. Free Radic Biol Med 45: 1729-1737. doi: 10.1016/j.freeradbiomed.2008.09.023 PMID: 18930811
25. Aharoni R, Herschkovitz A, Eilam R, Blumberg-Hazan M, Sela M, Bruck W, et al. (2008) Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 105: 11358-11363. doi: 10.1073/pnas.0804632105 PMID: 18678887
26. Marques KB, Scorisa JM, Zanon R, Freria CM, Santos LM, Damasceno BP, et al. (2009) The immunomodulator glatiramer acetate influences spinal motoneuron plasticity during the course of multiple sclerosis in an animal model. Braz J Med Biol Res 42: 179-188. PMID: 19274346
27. Emerson MR, LeVine SM (2000) Heme oxygenase-1 and NADPH cytochrome P450 reductase expression in experimental allergic encephalomyelitis: an expanded view of the stress response. J Neurochem 75: 2555-2562. PMID: 11080209
28. Schluesener HJ, Seid K (2000) Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis. J Neuroimmunol 110: 114-120. PMID: 11024540
29. Liu Y, Zhu B, Luo L, Li P, Paty DW, Cynader MS (2001) Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis. Neuroreport 12: 1841-1845. PMID: 11435909
30. Chakrabarty A, Emerson MR, LeVine SM (2003) Heme oxygenase-1 in SJL mice with experimental allergic encephalomyelitis. Mult Scler 9: 372-381. PMID: 12926842
31. Unuma K, Aki T, Matsuda S, Funakoshi T, Yoshida K, Uemura K (2013) Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver. Hepatol Res 43: 91-96. doi: 10.1111/j.1872-034X.2012.01049.x PMID: 23231766
32. Song W, Zukor H, Lin SH, Liberman A, Tavitian A, Mui J, et al. (2012) Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. J Neurochem 123: 325-336. doi: 10.1111/j.1471-4159.2012.07914.x PMID: 22881289
33. Schipper HM, Song W, Zukor H, Hascalovici JR, Zeligman D (2009) Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement. J Neurochem 110: 469-485. doi: 10.1111/j.1471-4159.2009.06160.x PMID: 19457088
34. LeVine SM, Bilgen M, Lynch SG (2013) Iron accumulation in multiple sclerosis: an early pathogenic event. Expert Rev Neurother 13: 247-250. doi: 10.1586/ern.13.14 PMID: 23448214
35. Stahnke T, Stadelmann C, Netzler A, Bruck W, Richter-Landsberg C (2007) Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders. J Mol Neurosci 32: 25-37. PMID: 17873285