Optimization of nanostructured lipid carriers loaded with methotrexate: A tool for inflammatory and cancer therapy

International Journal of Pharmaceutics

Volumn 492, Issue 1-2, 2015, Pages 65-72

  Ferreira, Mara ^a   Chaves, Luíse L ^a   Lima, Sofia A Costa ^a   Reis, Salette ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Box Behnken design; Hot ultrasonication; In vitro drug release; L929 fibroblasts; Lipid colloidal carriers; Methotrexate; Mygliol 812; Storage stability; Witepsol E85

Indexed keywords

CETYL PALMITATE; IMWITOR 308; LIPOCIRE; METHOTREXATE; MYGLIOL 812; NANOCARRIER; NANOSTRUCTURED LIPID CARRIER; PALMITIC ACID DERIVATIVE; SUPPOSITORY BASE; UNCLASSIFIED DRUG; WITEPSOL E 76; WITEPSOL E 85; WITEPSOL H 32; WITEPSOL S 51; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC ANTIMETABOLITE; DRUG CARRIER; MIGLYOL; NANOMATERIAL; TRIACYLGLYCEROL; WITEPSOL;

ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; FACTORIAL DESIGN; MTT ASSAY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PSORIASIS; RHEUMATOID ARTHRITIS; SOLUBILIZATION; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE; CELL SURVIVAL; DRUG CARRIERS; DRUG LIBERATION; DRUG STABILITY; METHOTREXATE; MICE; NANOSTRUCTURES; TRIGLYCERIDES;

EID: 84937573964     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.07.013     Document Type: Article

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