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Volumn 61, Issue 5, 2006, Pages 375-386

Preparation, characterization and physico-chemical properties of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC): Their benefits as colloidal drug carrier systems

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; IOTROLAN; SOLID LIPID NANOPARTICLE; TOCOPHEROL;

EID: 33646540716     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (316)

References (125)
  • 1
    • 0030944482 scopus 로고    scopus 로고
    • Peptide-loaded solid lipid nanoparticles (SLN): Influence of production parameters
    • Almeida A, Runge S, Müller RH (1997) Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters. Int J Pharm 149: 255-265.
    • (1997) Int J Pharm , vol.149 , pp. 255-265
    • Almeida, A.1    Runge, S.2    Müller, R.H.3
  • 2
    • 0034960971 scopus 로고    scopus 로고
    • Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - Tissue distribution
    • Bargoni A, Cavalli R, Zara GP, Fundaro A, Caputo O, Gasco MR (2001) Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - Tissue distribution. Pharm Res 43: 497-502.
    • (2001) Pharm Res , vol.43 , pp. 497-502
    • Bargoni, A.1    Cavalli, R.2    Zara, G.P.3    Fundaro, A.4    Caputo, O.5    Gasco, M.R.6
  • 3
    • 0023033076 scopus 로고
    • Les formes vectorisées ou à distribution modulée, nouveaux systèmes d'administration des médicaments
    • Benoit JP, Couvreur P, Devissaguet JP, Fessi H, Puisieux F, Roblot-Treupel L (1986) Les formes vectorisées ou à distribution modulée, nouveaux systèmes d'administration des médicaments. J Pharm Belg 41: 319-329.
    • (1986) J Pharm Belg , vol.41 , pp. 319-329
    • Benoit, J.P.1    Couvreur, P.2    Devissaguet, J.P.3    Fessi, H.4    Puisieux, F.5    Roblot-Treupel, L.6
  • 4
    • 33646583596 scopus 로고    scopus 로고
    • The surface structure of lipid drug carriers-influence on carrier-cell interaction
    • Müller RH, Mehnert W (eds.), Medpharm, Stuttgart
    • Bergelson L, Domb A (1997) The surface structure of lipid drug carriers-influence on carrier-cell interaction. In: Müller RH, Mehnert W (eds.), Particle and surface characterization methods, Medpharm, Stuttgart.
    • (1997) Particle and Surface Characterization Methods
    • Bergelson, L.1    Domb, A.2
  • 5
    • 0028917883 scopus 로고
    • Do nanoparticles prepared from lipids solid at room temperature always possess a solid lipid matrix?
    • Bunjes H, Westesen K (1995) Do nanoparticles prepared from lipids solid at room temperature always possess a solid lipid matrix? Int J Pharm 115: 129-131.
    • (1995) Int J Pharm , vol.115 , pp. 129-131
    • Bunjes, H.1    Westesen, K.2
  • 6
    • 0029876015 scopus 로고    scopus 로고
    • Crystallization tendency and polymorphic transitions in triglyceride nanoparticles
    • Bunjes H, Koch MHJ, Westesen K (1996) Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int J Pharm 129: 159-173.
    • (1996) Int J Pharm , vol.129 , pp. 159-173
    • Bunjes, H.1    Koch, M.H.J.2    Westesen, K.3
  • 7
    • 0038082476 scopus 로고    scopus 로고
    • Influence of emulsifiers on the crystallization of solid lipid nanoparticles
    • Bunjes H, Koch MHJ, Westesen K (2003) Influence of emulsifiers on the crystallization of solid lipid nanoparticles. J Pharm Sci 92: 1509-1520.
    • (2003) J Pharm Sci , vol.92 , pp. 1509-1520
    • Bunjes, H.1    Koch, M.H.J.2    Westesen, K.3
  • 8
    • 0028897685 scopus 로고
    • Preparation and evaluation of colloidal lipospheres containing pilocarpine as ion pair
    • Cavalli R, Morel S, Gasco MR, Chetoni P, Saettone MF (1995) Preparation and evaluation of colloidal lipospheres containing pilocarpine as ion pair. Int J Pharm 117: 243-246.
    • (1995) Int J Pharm , vol.117 , pp. 243-246
    • Cavalli, R.1    Morel, S.2    Gasco, M.R.3    Chetoni, P.4    Saettone, M.F.5
  • 10
    • 0032918773 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as carriers of hydrocortisone and progesterone complexes with β-cyclodextrins
    • Cavalli R, Peira E, Caputo O, Gasco MR (1999) Solid lipid nanoparticles as carriers of hydrocortisone and progesterone complexes with β-cyclodextrins. Int J Pharm 182: 59-69.
    • (1999) Int J Pharm , vol.182 , pp. 59-69
    • Cavalli, R.1    Peira, E.2    Caputo, O.3    Gasco, M.R.4
  • 11
    • 0033694268 scopus 로고    scopus 로고
    • Transmucosal transport of tobramycin incorporated in SLN after duodenal administration to rats. Part I - A pharmacokinetic study
    • Cavalli R, Zara GP, Caputo O, Bargoni A, Fundaro A, Gasco MR (2000) Transmucosal transport of tobramycin incorporated in SLN after duodenal administration to rats. Part I - a pharmacokinetic study. Pharmacol Res 42: 541-545.
    • (2000) Pharmacol Res , vol.42 , pp. 541-545
    • Cavalli, R.1    Zara, G.P.2    Caputo, O.3    Bargoni, A.4    Fundaro, A.5    Gasco, M.R.6
  • 13
    • 0034760365 scopus 로고    scopus 로고
    • In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel
    • Chen DB, Yang TZ, Lu WL, Zhang Q (2001) In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel. Chem Pharm Bull 49: 1444-1447.
    • (2001) Chem Pharm Bull , vol.49 , pp. 1444-1447
    • Chen, D.B.1    Yang, T.Z.2    Lu, W.L.3    Zhang, Q.4
  • 15
    • 0036130944 scopus 로고    scopus 로고
    • Production of lipospheres as carriers for bioactive compounds
    • Cortesi R, Esposito E, Luca G, Nastruzzi C (2002) Production of lipospheres as carriers for bioactive compounds. Biomaterials 23: 2283-2294.
    • (2002) Biomaterials , vol.23 , pp. 2283-2294
    • Cortesi, R.1    Esposito, E.2    Luca, G.3    Nastruzzi, C.4
  • 16
    • 0036164530 scopus 로고    scopus 로고
    • Vehicles for oligonucleotide delivery to tumours
    • Dass CR (2002) Vehicles for oligonucleotide delivery to tumours. J Pharm Pharmacol 54: 3-27.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 3-27
    • Dass, C.R.1
  • 17
    • 0028963022 scopus 로고
    • Preparation and structure of a water-in-oil cream containing lipid nanoparticles
    • De Vringer T, De Ronde HAG (1995) Preparation and structure of a water-in-oil cream containing lipid nanoparticles. J Pharm Sci 84: 466-472.
    • (1995) J Pharm Sci , vol.84 , pp. 466-472
    • De Vringer, T.1    De Ronde, H.A.G.2
  • 18
    • 0035072395 scopus 로고    scopus 로고
    • Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles
    • Demirel M, Yazan Y, Müller RH, Kiliç F, Bozan B (2001) Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles. J Microencapsul 18: 359-371.
    • (2001) J Microencapsul , vol.18 , pp. 359-371
    • Demirel, M.1    Yazan, Y.2    Müller, R.H.3    Kiliç, F.4    Bozan, B.5
  • 19
    • 0028219328 scopus 로고
    • Lioposomen in kosmetika und arzneimitteln
    • Diederichs JE, Müller RH (1994) Lioposomen in Kosmetika und Arzneimitteln. Pharm Ind 56: 267-275.
    • (1994) Pharm Ind , vol.56 , pp. 267-275
    • Diederichs, J.E.1    Müller, R.H.2
  • 21
    • 0032850455 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN™/Lipopearls™) - A pharmaceutical and cosmetic carrier for the application of vitamin e in dermal products
    • Dingler A, Blum RP, Niehus H, Müller RH, Gohla S (1999) Solid lipid nanoparticles (SLN™/Lipopearls™) - a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products. J Microencapsul 16: 751-767.
    • (1999) J Microencapsul , vol.16 , pp. 751-767
    • Dingler, A.1    Blum, R.P.2    Niehus, H.3    Müller, R.H.4    Gohla, S.5
  • 22
    • 0025732814 scopus 로고
    • Polymorphic behaviour of sprayed lipid micropellets and its evaluation by differential scanning calorimetry and scanning electron microscopy
    • Eldem T, Speiser P, Altorfer H (1991) Polymorphic behaviour of sprayed lipid micropellets and its evaluation by differential scanning calorimetry and scanning electron microscopy. Pharm Res 8: 178-184.
    • (1991) Pharm Res , vol.8 , pp. 178-184
    • Eldem, T.1    Speiser, P.2    Altorfer, H.3
  • 23
    • 0024041158 scopus 로고
    • Prolonged aqueous humor levels of subconjunctival antibiotics after treatment with acetazolamide and/or timolol
    • Ellis PP, Riegel M (1988) Prolonged aqueous humor levels of subconjunctival antibiotics after treatment with acetazolamide and/or timolol. Ophthalmic Surg 19: 501-505.
    • (1988) Ophthalmic Surg , vol.19 , pp. 501-505
    • Ellis, P.P.1    Riegel, M.2
  • 25
    • 0343407048 scopus 로고    scopus 로고
    • Spray-drying of solid lipid nanoparticles (SLN™)
    • Freitas C, Müller RH (1998a) Spray-drying of solid lipid nanoparticles (SLN™). Eur J Pharm Biopharm 46: 145-151.
    • (1998) Eur J Pharm Biopharm , vol.46 , pp. 145-151
    • Freitas, C.1    Müller, R.H.2
  • 26
    • 0032526787 scopus 로고    scopus 로고
    • Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN™) dispersions
    • Freitas C, Müller RH (1998b) Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN™) dispersions. Int J Pharm 168: 221-229.
    • (1998) Int J Pharm , vol.168 , pp. 221-229
    • Freitas, C.1    Müller, R.H.2
  • 27
    • 0345390953 scopus 로고    scopus 로고
    • Correlation between long-term stability of solid lipid nanoparticles (SLN™) and crystallinity of the lipid phase
    • Freitas C, Müller RH (1999) Correlation between long-term stability of solid lipid nanoparticles (SLN™) and crystallinity of the lipid phase. Eur J Pharm Biopharm 47: 125-132.
    • (1999) Eur J Pharm Biopharm , vol.47 , pp. 125-132
    • Freitas, C.1    Müller, R.H.2
  • 28
    • 0033800767 scopus 로고    scopus 로고
    • Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tissue distribution after i.v. administration to rats
    • Fundaro A, Cavalli R, Bargoni A, Vighetto D, Zara GP, Gasco MR (2000) Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats. Pharm Res 42: 337-343.
    • (2000) Pharm Res , vol.42 , pp. 337-343
    • Fundaro, A.1    Cavalli, R.2    Bargoni, A.3    Vighetto, D.4    Zara, G.P.5    Gasco, M.R.6
  • 29
    • 33646538545 scopus 로고    scopus 로고
    • (1993) Method for producing solid lipid microspheres having a narrow size distribution. US Patent 5 250 236
    • Gasco MR (1993) Method for producing solid lipid microspheres having a narrow size distribution. US Patent 5 250 236.
    • Gasco, M.R.1
  • 30
    • 0002084024 scopus 로고    scopus 로고
    • Solid lipid nanospheres from warm micro-emulsions
    • Gasco MR (1997) Solid lipid nanospheres from warm micro-emulsions. Pharm Technol Eur 9: 52-58.
    • (1997) Pharm Technol Eur , vol.9 , pp. 52-58
    • Gasco, M.R.1
  • 31
    • 0035142849 scopus 로고    scopus 로고
    • Scaling up feasibility of the production of solid lipid nanoparticles (SLN™)
    • Gohla SH, Dingler A (2001) Scaling up feasibility of the production of solid lipid nanoparticles (SLN™). Pharmazie 56: 61-63.
    • (2001) Pharmazie , vol.56 , pp. 61-63
    • Gohla, S.H.1    Dingler, A.2
  • 32
    • 0037433813 scopus 로고    scopus 로고
    • Interactions of amphiphilic calix[4]arene-based solid lipid nanoparticles with bovine serum albumin
    • Gualbert J, Shahgaldian P, Coleman AW (2003) Interactions of amphiphilic calix[4]arene-based solid lipid nanoparticles with bovine serum albumin. Int J Pharm 257: 69-73.
    • (2003) Int J Pharm , vol.257 , pp. 69-73
    • Gualbert, J.1    Shahgaldian, P.2    Coleman, A.W.3
  • 33
    • 0031040884 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as drug carriers I. Incorporation and retention of the lipophilic pro-drug 3′-azido-3′-deoxythymidine palmitate
    • Heiati H, Tawashi R, SMvers RR, Philips NC (1997) Solid lipid nanoparticles as drug carriers I. Incorporation and retention of the lipophilic pro-drug 3′-azido-3′-deoxythymidine palmitate. Int J Pharm 146:123-131.
    • (1997) Int J Pharm , vol.146 , pp. 123-131
    • Heiati, H.1    Tawashi, R.2    Smvers, R.R.3    Philips, N.C.4
  • 35
    • 51249187772 scopus 로고
    • The role of X-ray diffraction in studies of the crystallography of monoacid saturated triglycerides
    • Hoerr CW, Paulicka FR (1968) The role of X-ray diffraction in studies of the crystallography of monoacid saturated triglycerides. J Am Oil Chem Soc 45: 793-797.
    • (1968) J Am Oil Chem Soc , vol.45 , pp. 793-797
    • Hoerr, C.W.1    Paulicka, F.R.2
  • 36
    • 0037404980 scopus 로고    scopus 로고
    • The production and characteristics of solid lipid nanoparticles (SLNs)
    • Hou DZ, Xie CS, Huang K, Zhu CH (2003) The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials 24: 1781-1785.
    • (2003) Biomaterials , vol.24 , pp. 1781-1785
    • Hou, D.Z.1    Xie, C.S.2    Huang, K.3    Zhu, C.H.4
  • 37
    • 0037018963 scopus 로고    scopus 로고
    • Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization
    • Hu FQ, Yuan H, Zhang HH, Fang M (2002) Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int J Pharm 239: 121-128.
    • (2002) Int J Pharm , vol.239 , pp. 121-128
    • Hu, F.Q.1    Yuan, H.2    Zhang, H.H.3    Fang, M.4
  • 38
    • 1542358757 scopus 로고    scopus 로고
    • Preparation and characterization of solid lipid nanoparticles containing peptide
    • Hu FQ, Hong Y, Yuan H (2004) Preparation and characterization of solid lipid nanoparticles containing peptide. Int J Pharm 273: 29-35.
    • (2004) Int J Pharm , vol.273 , pp. 29-35
    • Hu, F.Q.1    Hong, Y.2    Yuan, H.3
  • 40
    • 5344275227 scopus 로고    scopus 로고
    • Investigation on the flow behaviour of dispersions of solid triglyceride nanoparticles
    • Illing A, Unruh T (2004) Investigation on the flow behaviour of dispersions of solid triglyceride nanoparticles. Int J Pharm 284: 123-131.
    • (2004) Int J Pharm , vol.284 , pp. 123-131
    • Illing, A.1    Unruh, T.2
  • 43
    • 0033982781 scopus 로고    scopus 로고
    • Comparison of wax and glyceride solid lipid nanoparticles (SLN®)
    • Jenning V, Gohla S (2000) Comparison of wax and glyceride solid lipid nanoparticles (SLN®). Int J Pharm 196: 219-222.
    • (2000) Int J Pharm , vol.196 , pp. 219-222
    • Jenning, V.1    Gohla, S.2
  • 44
    • 0034595218 scopus 로고    scopus 로고
    • Vitamin A-loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting to the upper skin
    • Jenning V, Gysler A, Schäfer-Korting M, Gohla S (2000a) Vitamin A-loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm 49: 211-218.
    • (2000) Eur J Pharm Biopharm , vol.49 , pp. 211-218
    • Jenning, V.1    Gysler, A.2    Schäfer-Korting, M.3    Gohla, S.4
  • 46
    • 17344391922 scopus 로고    scopus 로고
    • Vitamin A-loaded solid lipid nanoparticles for topical use: Drug release properties
    • Jenning V, Schäfer-Korting M, Gohla S (2000c) Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release 66: 115-126.
    • (2000) J Control Release , vol.66 , pp. 115-126
    • Jenning, V.1    Schäfer-Korting, M.2    Gohla, S.3
  • 47
    • 0343618485 scopus 로고    scopus 로고
    • Characterization of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids
    • Jenning V, Thünemann AF, Gohla SH (2000d) Characterization of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int J Pharm 199: 167-177.
    • (2000) Int J Pharm , vol.199 , pp. 167-177
    • Jenning, V.1    Thünemann, A.F.2    Gohla, S.H.3
  • 48
    • 0035109447 scopus 로고    scopus 로고
    • Encapsulation of retinoids in solid lipid nanoparticles (SLN)
    • Jenning V, Gohla S (2001) Encapsulation of retinoids in solid lipid nanoparticles (SLN). J Microencapsul 18: 149-158.
    • (2001) J Microencapsul , vol.18 , pp. 149-158
    • Jenning, V.1    Gohla, S.2
  • 49
    • 1242338847 scopus 로고    scopus 로고
    • Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy
    • Jores K, Mehnert W, Dreschler M, Bunjes H, Johann C, Mäder K (2004) Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy. J Control Release 95: 217-227.
    • (2004) J Control Release , vol.95 , pp. 217-227
    • Jores, K.1    Mehnert, W.2    Dreschler, M.3    Bunjes, H.4    Johann, C.5    Mäder, K.6
  • 50
    • 0019956120 scopus 로고
    • Toxicity of polyalkylcyanoacrylate nanoparticles. I: Free nanoparticles
    • Kante B, Couvreur P, Dubois-Krack G, De Meester C (1982) Toxicity of polyalkylcyanoacrylate nanoparticles. I: Free nanoparticles. J Pharm Sci 71: 786-789.
    • (1982) J Pharm Sci , vol.71 , pp. 786-789
    • Kante, B.1    Couvreur, P.2    Dubois-Krack, G.3    De Meester, C.4
  • 53
    • 0035966519 scopus 로고    scopus 로고
    • Improved skin oxygenation after benzyl nicotinate application in different carriers as measured by EPR oximetry in vivo
    • Kržič M, Šentjurc M, Kristl J (2001) Improved skin oxygenation after benzyl nicotinate application in different carriers as measured by EPR oximetry in vivo. J Control Release 70: 203-211.
    • (2001) J Control Release , vol.70 , pp. 203-211
    • Kržič, M.1    Šentjurc, M.2    Kristl, J.3
  • 54
    • 0031800381 scopus 로고    scopus 로고
    • Novel applications of liposomes
    • Lasic DD (1998) Novel applications of liposomes. Tibtech 16: 307-321.
    • (1998) Tibtech , vol.16 , pp. 307-321
    • Lasic, D.D.1
  • 55
    • 0037190052 scopus 로고    scopus 로고
    • Formulation parameters determining the physico-chemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid
    • Lim SJ, Kim CK (2002) Formulation parameters determining the physico-chemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid. Int J Pharm 243: 135-146.
    • (2002) Int J Pharm , vol.243 , pp. 135-146
    • Lim, S.J.1    Kim, C.K.2
  • 56
    • 7444255422 scopus 로고    scopus 로고
    • Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders
    • Lim SJ, Lee MK, Kim CK (2004) Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders. J Control Release 100: 53-61.
    • (2004) J Control Release , vol.100 , pp. 53-61
    • Lim, S.J.1    Lee, M.K.2    Kim, C.K.3
  • 57
    • 2542583104 scopus 로고    scopus 로고
    • Purification of nanoparticle suspensions by a concentration/diafiltration process
    • Limayem I, Charcosset C, Fessi H (2004) Purification of nanoparticle suspensions by a concentration/diafiltration process. Sep Pur Technol 38: 1-9.
    • (2004) Sep Pur Technol , vol.38 , pp. 1-9
    • Limayem, I.1    Charcosset, C.2    Fessi, H.3
  • 58
    • 0036008754 scopus 로고    scopus 로고
    • Semisolid SLN™ dispersions for topical application: Influence of formulation and production parameters on viscoelastic properties
    • Lippacher A, Müller RH, Mäder K (2002) Semisolid SLN™ dispersions for topical application: influence of formulation and production parameters on viscoelastic properties. Eur J Pharm Biopharm 53: 155-160.
    • (2002) Eur J Pharm Biopharm , vol.53 , pp. 155-160
    • Lippacher, A.1    Müller, R.H.2    Mäder, K.3
  • 60
    • 0030747686 scopus 로고    scopus 로고
    • Solid lipid nanoparticles -ein neuartiger Wirkstoff-carrier für kosmetika und pharmazeutika, 2. Mitteilung: Wirkstoff -inkorporation, freisetzung und sterilisierbarkeit
    • Mehnert W, Zur Mühlen A, Dingler A, Weyhers H, Müller RH (1997) Solid lipid Nanoparticles -ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika, 2. Mitteilung: Wirkstoff -Inkorporation, Freisetzung und Sterilisierbarkeit. Pharm Ind 59: 511-514.
    • (1997) Pharm Ind , vol.59 , pp. 511-514
    • Mehnert, W.1    Zur Mühlen, A.2    Dingler, A.3    Weyhers, H.4    Müller, R.H.5
  • 61
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles. Production, characterization and applications
    • Mehnert W, Mäder K (2001) Solid lipid nanoparticles. Production, characterization and applications. Adv Drug Del Rev 47: 165-196.
    • (2001) Adv Drug del Rev , vol.47 , pp. 165-196
    • Mehnert, W.1    Mäder, K.2
  • 62
    • 0042335999 scopus 로고    scopus 로고
    • Solid lipid nanoparticle and microemulsion for topical delivery of triptolide
    • Mei Z, Chen H, Weng T, Yang Y, Yang X (2003) Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. Eur J Pharm Biopharm 56: 189-196.
    • (2003) Eur J Pharm Biopharm , vol.56 , pp. 189-196
    • Mei, Z.1    Chen, H.2    Weng, T.3    Yang, Y.4    Yang, X.5
  • 64
    • 0031960549 scopus 로고    scopus 로고
    • NMR relaxometric investigations of solid lipid nanoparticles (SLN) containing gadolinium (III) complexes
    • Morel S, Terreno E, Ugazio E, Aime S, Gasco MR (1998) NMR relaxometric investigations of solid lipid nanoparticles (SLN) containing gadolinium (III) complexes. Eur J Pharm Biopharm 45: 157-163.
    • (1998) Eur J Pharm Biopharm , vol.45 , pp. 157-163
    • Morel, S.1    Terreno, E.2    Ugazio, E.3    Aime, S.4    Gasco, M.R.5
  • 66
    • 0028113746 scopus 로고
    • Incorporation of lipophilic drugs and drug release profiles of solid lipid nanoparticles (SLN)
    • Müller RH, Schwarz C, Zur Mühlen, Mehnert W (1994) Incorporation of lipophilic drugs and drug release profiles of solid lipid nanoparticles (SLN) Proc Int Symp Control Rel Bioact Mater 21: 146-147.
    • (1994) Proc Int Symp Control Rel Bioact Mater , vol.21 , pp. 146-147
    • Müller, R.H.1    Schwarz, C.2    Mühlen, Z.3    Mehnert, W.4
  • 69
    • 0029844511 scopus 로고    scopus 로고
    • Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with Poloxamine 908 and Poloxamer 407
    • Müller RH, Maaßen S, Weyhers H, Mehnert W (1996a) Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with Poloxamine 908 and Poloxamer 407. J Drug Target 4: 161-170.
    • (1996) J Drug Target , vol.4 , pp. 161-170
    • Müller, R.H.1    Maaßen, S.2    Weyhers, H.3    Mehnert, W.4
  • 70
    • 0030581141 scopus 로고    scopus 로고
    • Cytotoxicity of magnetite loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles (SLN)
    • Müller RH, Maaßen S, Weyhers H, Specht F, Lucks JS (1996b) Cytotoxicity of magnetite loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles (SLN). Int J Pharm 138: 85-94.
    • (1996) Int J Pharm , vol.138 , pp. 85-94
    • Müller, R.H.1    Maaßen, S.2    Weyhers, H.3    Specht, F.4    Lucks, J.S.5
  • 71
    • 4243591395 scopus 로고    scopus 로고
    • Feste lipid-nanopartikel als neuartige carrier für wirkstoffe
    • Müller RH, Dingler A (1998) Feste Lipid-Nanopartikel als neuartige Carrier für Wirkstoffe. Pharm Ztg 143: 4237-4241.
    • (1998) Pharm Ztg , vol.143 , pp. 4237-4241
    • Müller, R.H.1    Dingler, A.2
  • 72
    • 0001546815 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN®) for controlled drug delivery
    • Benita S (ed.), Harwood Academic Publishers, The Netherlands
    • Müller RH, Runge SA (1998) Solid lipid nanoparticles (SLN®) for controlled drug delivery. In: Benita S (ed.) Submicron emulsion in drug targeting and delivery, Harwood Academic Publishers, The Netherlands, p. 219-234.
    • (1998) Submicron Emulsion in Drug Targeting and Delivery , pp. 219-234
    • Müller, R.H.1    Runge, S.A.2
  • 73
    • 0038009986 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Phagocytic uptake, in vitro cytotoxicity and in vitro biodegradation, 2nd communication
    • Müller RH, Olbrich C (1999) Solid lipid nanoparticles: phagocytic uptake, in vitro cytotoxicity and in vitro biodegradation, 2nd communication. Pharm. Ind. 61: 564-569.
    • (1999) Pharm Ind , vol.61 , pp. 564-569
    • Müller, R.H.1    Olbrich, C.2
  • 74
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery - A review of the state of the art
    • Müller RH, Mäder K, Gohla S (2000) Solid lipid nanoparticles (SLN) for controlled drug delivery -a review of the state of the art. Eur J Pharm Biopharm 50: 161-177.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 161-177
    • Müller, R.H.1    Mäder, K.2    Gohla, S.3
  • 75
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    • Müller RH, Radtke M, Wissing SA (2002a) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 54, Suppl. 1: S131-S155.
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.SUPPL. 1
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 76
    • 0037151496 scopus 로고    scopus 로고
    • Nanostructured lipid matrices for improved microencapsulation of drugs
    • Müller RH, Radtke M, Wissing SA (2002b) Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 242: 121-128.
    • (2002) Int J Pharm , vol.242 , pp. 121-128
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 77
    • 0023695440 scopus 로고
    • In vivo release profiles of leuprolide acetate from microcapsules with polylactic acids or copoly(lactic/glycolic)acids and in vivo degradation of these polymers
    • Ogawa Y (1988) In vivo release profiles of leuprolide acetate from microcapsules with polylactic acids or copoly(lactic/glycolic)acids and in vivo degradation of these polymers. Chem Pharm Bull 36: 2576-2581.
    • (1988) Chem Pharm Bull , vol.36 , pp. 2576-2581
    • Ogawa, Y.1
  • 78
    • 0345148806 scopus 로고    scopus 로고
    • Enzymatic degradation of SLN - Effect of surfactant and surfactant mixtures
    • Olbrich C, Müller RH (1999) Enzymatic degradation of SLN - effect of surfactant and surfactant mixtures. Int J Pharm 180: 31-39.
    • (1999) Int J Pharm , vol.180 , pp. 31-39
    • Olbrich, C.1    Müller, R.H.2
  • 80
    • 0037177514 scopus 로고    scopus 로고
    • Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN) - Effect of surfactants, storage time and crystallinity
    • Olbrich C, Kayser O, Müller RH (2002) Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN) - effect of surfactants, storage time and crystallinity. Int J Pharm 237: 119-128.
    • (2002) Int J Pharm , vol.237 , pp. 119-128
    • Olbrich, C.1    Kayser, O.2    Müller, R.H.3
  • 81
    • 0038408645 scopus 로고    scopus 로고
    • Study of solid lipid nanoparticles with respect to particle size distribution and drug loading
    • Patravale VB, Ambarkhane AV (2003) Study of solid lipid nanoparticles with respect to particle size distribution and drug loading. Pharmazie 58: 392-395.
    • (2003) Pharmazie , vol.58 , pp. 392-395
    • Patravale, V.B.1    Ambarkhane, A.V.2
  • 82
    • 33646556518 scopus 로고    scopus 로고
    • (1999) Pharmaceutical cyclosporine formulation with improved biopharmaceutical properties, improved physical quality and greater stability, and method for producing said formulation, WO 99/56733
    • Penkler L, Müller RH, Runge SA, Ravelli V (1999) Pharmaceutical cyclosporine formulation with improved biopharmaceutical properties, improved physical quality and greater stability, and method for producing said formulation, WO 99/56733.
    • Penkler, L.1    Müller, R.H.2    Runge, S.A.3    Ravelli, V.4
  • 86
    • 0011625022 scopus 로고    scopus 로고
    • Nanostructured lipid carriers: The new generation of lipid drug carriers
    • Radtke M, Müller RH (2001) Nanostructured lipid carriers: the new generation of lipid drug carriers. New Drugs 2: 48-52.
    • (2001) New Drugs , vol.2 , pp. 48-52
    • Radtke, M.1    Müller, R.H.2
  • 88
    • 4244203485 scopus 로고    scopus 로고
    • SLN (solid lipid nanoparticles), a novel formulation for the oral administration of drugs
    • Runge S, Mehnert W, Müller RH (1996) SLN (solid lipid nanoparticles), a novel formulation for the oral administration of drugs. Eur J Pharm Sci 4 Suppl 1: S132.
    • (1996) Eur J Pharm Sci , vol.4 , Issue.SUPPL. 1
    • Runge, S.1    Mehnert, W.2    Müller, R.H.3
  • 90
    • 0002924931 scopus 로고
    • Crystallization of fats and fatty acids
    • Garti N, Sato K (eds.), Marcel Dekker, New York
    • Sato K (1988) Crystallization of fats and fatty acids. In: Garti N, Sato K (eds.), Crystallization and polymorphism of fats and fatty acids, Marcel Dekker, New York, p. 227-266.
    • (1988) Crystallization and Polymorphism of Fats and Fatty Acids , pp. 227-266
    • Sato, K.1
  • 91
    • 0037240251 scopus 로고    scopus 로고
    • Solvent injection as a new approach for manufacturing lipid nanoparticles - Evaluation of the method and process parameters
    • Schubert MA, Müller-Goyman CC (2003) Solvent injection as a new approach for manufacturing lipid nanoparticles - evaluation of the method and process parameters. Eur J Pharm Biopharm 55: 125-131.
    • (2003) Eur J Pharm Biopharm , vol.55 , pp. 125-131
    • Schubert, M.A.1    Müller-Goyman, C.C.2
  • 92
    • 0028285718 scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization
    • Schwarz C, Mehnert W, Lucks JS, Müller RH (1994) Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J Control Release 30: 83-96.
    • (1994) J Control Release , vol.30 , pp. 83-96
    • Schwarz, C.1    Mehnert, W.2    Lucks, J.S.3    Müller, R.H.4
  • 94
    • 0030817849 scopus 로고    scopus 로고
    • Freeze-drying of drug-free and drug-loaded solid lipid nanoparticles (SLN)
    • Schwarz C, Mehnert W (1997) Freeze-drying of drug-free and drug-loaded solid lipid nanoparticles (SLN). Int J Pharm 157: 171-179.
    • (1997) Int J Pharm , vol.157 , pp. 171-179
    • Schwarz, C.1    Mehnert, W.2
  • 96
    • 0037422347 scopus 로고    scopus 로고
    • Paraacyl-calix-arene based solid lipid nanoparticles (SLNs): A detailed study of preparation and stability parameters
    • Shahgaldian P, Da Silva E, Coleman AW, Rather B, Zaworotko MJ (2003a) Paraacyl-calix-arene based solid lipid nanoparticles (SLNs): a detailed study of preparation and stability parameters. Int J Pharm 253: 23-38.
    • (2003) Int J Pharm , vol.253 , pp. 23-38
    • Shahgaldian, P.1    Da Silva, E.2    Coleman, A.W.3    Rather, B.4    Zaworotko, M.J.5
  • 97
    • 0037333422 scopus 로고    scopus 로고
    • A study of the freeze-drying conditions of calixarene based solid lipid nanoparticles
    • Shahgaldian P, Gualbert J, Aïssa K, Coleman W (2003b) A study of the freeze-drying conditions of calixarene based solid lipid nanoparticles. Eur J Pharm Biopharm 55: 181-184.
    • (2003) Eur J Pharm Biopharm , vol.55 , pp. 181-184
    • Shahgaldian, P.1    Gualbert, J.2    Aïssa, K.3    Coleman, W.4
  • 98
    • 0001469131 scopus 로고
    • Submicron-sized parenteral carrier systems based on solid lipids
    • Siekmann B, Westesen K (1992) Submicron-sized parenteral carrier systems based on solid lipids. Pharm Pharmacol Lett 1: 123-126.
    • (1992) Pharm Pharmacol Lett , vol.1 , pp. 123-126
    • Siekmann, B.1    Westesen, K.2
  • 100
    • 0028548631 scopus 로고
    • Thermoanalysis of recrystallisation process of melt-homogenized glyceride nanoparticles
    • Siekmann B, Westesen K (1994) Thermoanalysis of recrystallisation process of melt-homogenized glyceride nanoparticles. Colloids Surfaces B: Biointerfaces 3: 159-175.
    • (1994) Colloids Surfaces B: Biointerfaces , vol.3 , pp. 159-175
    • Siekmann, B.1    Westesen, K.2
  • 101
    • 0029901328 scopus 로고    scopus 로고
    • Investigations on solid lipid nanoparticles prepared by precipitation in o/w emulsions
    • Siekmann B, Westesen K (1996) Investigations on solid lipid nanoparticles prepared by precipitation in o/w emulsions. Eur J Pharm Biopharm 43: 104-109.
    • (1996) Eur J Pharm Biopharm , vol.43 , pp. 104-109
    • Siekmann, B.1    Westesen, K.2
  • 102
    • 0026679872 scopus 로고
    • Preparation of submicron drug particles in lecithin-stabilized o/w emulsions I. Model studies of the precipitation of cholesterylacetate
    • Sjostrom B, Bergenståhl B (1992) Preparation of submicron drug particles in lecithin-stabilized o/w emulsions I. Model studies of the precipitation of cholesterylacetate. Int J Pharm 88: 53-62.
    • (1992) Int J Pharm , vol.88 , pp. 53-62
    • Sjostrom, B.1    Bergenståhl, B.2
  • 103
    • 0022496987 scopus 로고
    • Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration
    • Smith A, Hunneyball JM (1986) Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration. Int J Pharm 30: 215-220.
    • (1986) Int J Pharm , vol.30 , pp. 215-220
    • Smith, A.1    Hunneyball, J.M.2
  • 104
    • 2442712381 scopus 로고    scopus 로고
    • Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
    • Souto EB, Wissing SA, Barbosa CM, Müller RH (2004) Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm 278: 71-77.
    • (2004) Int J Pharm , vol.278 , pp. 71-77
    • Souto, E.B.1    Wissing, S.A.2    Barbosa, C.M.3    Müller, R.H.4
  • 105
    • 33646554890 scopus 로고    scopus 로고
    • (1990) Lipid Nanopellets als Trägersystem für Arzneimittel zur Peroralen Anwendung. Europäisches Patent EP0167825
    • Speiser P (1990) Lipid Nanopellets als Trägersystem für Arzneimittel zur Peroralen Anwendung. Europäisches Patent EP0167825.
    • Speiser, P.1
  • 106
    • 0002820601 scopus 로고    scopus 로고
    • Poorly soluble drugs, a challenge in drug delivery
    • Müller RH, Benita S, Böhm BHL (eds.), Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart
    • Speiser P (1998) Poorly soluble drugs, a challenge in drug delivery. In: Müller RH, Benita S, Böhm BHL (eds.) Emulsions and nanosuspensions for the formulation of poorly soluble drugs, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, p. 15-28.
    • (1998) Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs , pp. 15-28
    • Speiser, P.1
  • 107
    • 1442359802 scopus 로고    scopus 로고
    • Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer
    • Tabatt K, Sameti M, Olbrich C, Müller RH, Lehr CM (2004) Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer. Eur J Pharm Biopharm 57: 155-162.
    • (2004) Eur J Pharm Biopharm , vol.57 , pp. 155-162
    • Tabatt, K.1    Sameti, M.2    Olbrich, C.3    Müller, R.H.4    Lehr, C.M.5
  • 108
    • 0037433842 scopus 로고    scopus 로고
    • Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique
    • Trotta M, Debernardi F, Caputo O (2003) Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. Int J Pharm 257: 153-160.
    • (2003) Int J Pharm , vol.257 , pp. 153-160
    • Trotta, M.1    Debernardi, F.2    Caputo, O.3
  • 110
    • 23844466230 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate
    • Üner M, Wissing SA, Yener G, Müller RH (2005a) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate. Pharmazie 60: 577-582.
    • (2005) Pharmazie , vol.60 , pp. 577-582
    • Üner, M.1    Wissing, S.A.2    Yener, G.3    Müller, R.H.4
  • 111
    • 27144491374 scopus 로고    scopus 로고
    • Investigation of skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel
    • Üner M, Wissing SA, Yener G, Müller RH (2005b) Investigation of skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel. Pharmazie 60: 751-755.
    • (2005) Pharmazie , vol.60 , pp. 751-755
    • Üner, M.1    Wissing, S.A.2    Yener, G.3    Müller, R.H.4
  • 112
    • 1542611547 scopus 로고    scopus 로고
    • Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles
    • Venkateswarlu V, Manjunath K (2004) Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J Control Release 95: 627-638.
    • (2004) J Control Release , vol.95 , pp. 627-638
    • Venkateswarlu, V.1    Manjunath, K.2
  • 113
    • 0027264830 scopus 로고
    • Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction
    • Westesen K, Siekmann B, Koch MHJ (1993) Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction. Int J Pharm 93: 189-199.
    • (1993) Int J Pharm , vol.93 , pp. 189-199
    • Westesen, K.1    Siekmann, B.2    Koch, M.H.J.3
  • 114
    • 0031006729 scopus 로고    scopus 로고
    • Investigation of the gel formation of phospholipid-stabilized solid lipid nanoparticles
    • Westesen K, Siekmann B (1997) Investigation of the gel formation of phospholipid-stabilized solid lipid nanoparticles. Int J Pharm 151: 35-45.
    • (1997) Int J Pharm , vol.151 , pp. 35-45
    • Westesen, K.1    Siekmann, B.2
  • 115
    • 0035465206 scopus 로고    scopus 로고
    • Investigations on the occlusive properties of solid lipid nanoparticles (SLN)
    • Wissing SA, Lippacher A, Müller RH (2001) Investigations on the occlusive properties of solid lipid nanoparticles (SLN). J Cosmet Sci 52: 313-324.
    • (2001) J Cosmet Sci , vol.52 , pp. 313-324
    • Wissing, S.A.1    Lippacher, A.2    Müller, R.H.3
  • 116
    • 0034924386 scopus 로고    scopus 로고
    • A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles
    • Wissing SA, Müller RH (2001) A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles. Int J Cosm Sci 23: 233-243.
    • (2001) Int J Cosm Sci , vol.23 , pp. 233-243
    • Wissing, S.A.1    Müller, R.H.2
  • 117
    • 1942453805 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for parenteral drug delivery
    • Wissing SA, Kayser O, Müller RH (2004) Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 56: 1257-1272.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1257-1272
    • Wissing, S.A.1    Kayser, O.2    Müller, R.H.3
  • 118
    • 0032950389 scopus 로고    scopus 로고
    • Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain
    • Yang SC, Lu LF, Cai Y, Zhu JB, Liang BW, Yang CZ (1999a) Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J Control Release 59: 299-307.
    • (1999) J Control Release , vol.59 , pp. 299-307
    • Yang, S.C.1    Lu, L.F.2    Cai, Y.3    Zhu, J.B.4    Liang, B.W.5    Yang, C.Z.6
  • 119
    • 0032909537 scopus 로고    scopus 로고
    • Body distribution of camptothecin solid lipid nanoparticles after oral administration
    • Yang S, Zhu J, Lu Y, Liang B, Yang C (1999b) Body distribution of camptothecin solid lipid nanoparticles after oral administration. Pharm Res 16: 751-757.
    • (1999) Pharm Res , vol.16 , pp. 751-757
    • Yang, S.1    Zhu, J.2    Lu, Y.3    Liang, B.4    Yang, C.5
  • 120
    • 0019977821 scopus 로고
    • The influence of drugs on the physical stability of fatty suppositories
    • Yoshino H, Kobayashi M, Samejima M (1982) The influence of drugs on the physical stability of fatty suppositories. Chem Pharm Bull 30: 992-1001.
    • (1982) Chem Pharm Bull , vol.30 , pp. 992-1001
    • Yoshino, H.1    Kobayashi, M.2    Samejima, M.3
  • 121
    • 0036073236 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats
    • Zara GP, Bargoni A, Cavelli R, Fundaro A, Vighetto D, Gasco MR (2002) Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats. J Pharm Sci 91: 1324-1333.
    • (2002) J Pharm Sci , vol.91 , pp. 1324-1333
    • Zara, G.P.1    Bargoni, A.2    Cavelli, R.3    Fundaro, A.4    Vighetto, D.5    Gasco, M.R.6
  • 122
    • 0343920873 scopus 로고    scopus 로고
    • Influence of different parameters on reconstitution of liyophilized SLN
    • Zimmermann E, Müller RH, Mäder K (2000) Influence of different parameters on reconstitution of liyophilized SLN. Int J Pharm 196: 211-213.
    • (2000) Int J Pharm , vol.196 , pp. 211-213
    • Zimmermann, E.1    Müller, R.H.2    Mäder, K.3
  • 124
    • 0342904970 scopus 로고    scopus 로고
    • Drug release and release mechanisms of prednisolone loaded solid lipid nanoparticles
    • Zur Mühlen A, Mehnert W (1998) Drug release and release mechanisms of prednisolone loaded solid lipid nanoparticles. Pharmazie 53: 552-555.
    • (1998) Pharmazie , vol.53 , pp. 552-555
    • Zur Mühlen, A.1    Mehnert, W.2
  • 125
    • 0031960962 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery -Drug release and release mechanism
    • Zur Mühlen A, Schwarz C, Mehnert W (1998) Solid lipid nanoparticles (SLN) for controlled drug delivery -Drug release and release mechanism. Eur J Pharm Biopharm 45: 149-155.
    • (1998) Eur J Pharm Biopharm , vol.45 , pp. 149-155
    • Zur Mühlen, A.1    Schwarz, C.2    Mehnert, W.3


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