Native Liquid Extraction Surface Analysis Mass Spectrometry: Analysis of Noncovalent Protein Complexes Directly from Dried Substrates

Journal of the American Society for Mass Spectrometry

Volumn 26, Issue 8, 2015, Pages 1320-1327

  Martin, Nicholas J ^a   Griffiths, Rian L ^a   Edwards, Rebecca L ^a,b   Cooper, Helen J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Direct surface sampling; Dried blood spots; LESA; Liquid extraction surface analysis; Liquid microjunction sampling; Native mass spectrometry; Proteins

Indexed keywords

BLOOD; DIMERS; DRUG PRODUCTS; FLUORINE COMPOUNDS; GLASS; HEMOGLOBIN; LIQUIDS; MASS SPECTROMETRY; PORPHYRINS; PROTEINS; SPECTROMETRY; SURFACE ANALYSIS;

DIRECT SURFACE SAMPLINGS; DRIED BLOOD SPOTS; LESA; LIQUID EXTRACTION; NATIVE MASS SPECTROMETRIES;

EXTRACTION;

APOMYOGLOBIN; DIMER; HEMOGLOBIN BETA CHAIN; MONOMER; MULTIPROTEIN COMPLEX; MYOGLOBIN; NONCOVALENT PROTEIN COMPLEX; POLYVINYLIDENE FLUORIDE; TETRAMER; UNCLASSIFIED DRUG; GLASS; PLASMA PROTEIN; POLYVINYL DERIVATIVE;

ANALYTIC METHOD; ARTICLE; DRIED BLOOD SPOT TESTING; FILTER; GEL PERMEATION CHROMATOGRAPHY; HEMOGLOBIN SYNTHESIS; HUMAN; ION TRANSPORT; IONIZATION; LIQUID EXTRACTION SURFACE ANALYSIS; MASS SPECTROMETRY; NORMAL HUMAN; PAPER; PROTEIN ANALYSIS; PROTEIN INTERACTION; TEMPERATURE; ADULT; CHEMISTRY; FEMALE; ISOLATION AND PURIFICATION; LIQUID LIQUID EXTRACTION; MALE; PROCEDURES;

ADULT; BLOOD PROTEINS; DRIED BLOOD SPOT TESTING; FEMALE; GLASS; HUMANS; LIQUID-LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; POLYVINYLS;

EID: 84937568477     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-015-1152-8     Document Type: Article

References (39)

1. Fenn, J.B., Mann, M., Meng, C.K., Wong, S.U., Whitehouse, C.M.: Electrospray ionization for mass spectrometry of large biomolecules. Science 246, 64-71 (1989)
2. Loo, J.A.: Studying noncovalent protein complexes by electrospray ionization mass spectrometry. Mass Spectrom. Rev. 16, 1-23 (1997)
3. Katta, V., Chait, B.T.: Observation of the heme-globin complex in native myoglobin by electrospray-ionization mass spectrometry. J. Am. Chem. Soc. 113, 8535-8537 (1991)
4. Light-Wahl, K.J., Schwartz, B.L., Smith, R.D.: Observation of the noncovalent quaternary associations of proteins by electrospray ionization mass spectrometry. J. Am. Chem. Soc. 116, 5271-5278 (1994)
5. Van den Heuvel, R.H.H., Heck, A.J.R.: Native protein mass spectrometry: from intact oligomers to functional machineries. Curr. Opin. Chem. Biol. 8, 519-526 (2004)
6. Heck, A.J.R.: Native mass spectrometry: a bridge between interactomics and structural biology. Nat. Methods 5, 927-933 (2008)
7. Pramanik, B.N., Bartner, P.L., Mirza, U.A., Liu, Y.H., Ganguly, A.K.: Electrospray ionization mass spectrometry for the study of noncovalent complexes: an emerging technology. J. Mass Spectrom. 33, 911-920 (1998)
8. Heck, J.R., Van den Heuvel, R.H.H.: Investigation of intact protein complexes by mass spectrometry. Mass Spectrom. Rev. 23, 368-389 (2003)
9. Felitsyn, N., Peschke, M., Kebarle, P.: Origin and number of charges observed on multiply-protonated native proteins produced by ESI. Int. J. Mass Spectrom. 219, 36-62 (2002)
10. Loo, J.A.: Electrospray ionization mass spectrometry: a technology for studying noncovalent macromolecular complexes. Int. J. Mass Spectrom. 200, 175-186 (2000)
11. Sobott, F., Robinson, C.V.: Protein complexes gain momentum. Curr. Opin. Struct. Biol. 12, 729-734 (2002)
12. Glocker, M., Bauer, S.H.J., Kast, J., Volz, J., Przybylski, M.: Characterization of specific noncovalent protein complexes by UV matrix-assisted laser desorption ionization mass spectrometry. J. Mass Spectrom. 31, 1221-1227 (1996)
13. Takats, Z., Wiseman, J.M., Gologan, B., Cooks, G.R.: Electrosonic spray ionization. A gentle technique for generating folded proteins and protein complexes in the gas phase and for studying ion-molecule reactions at atmospheric pressure. Anal. Chem. 76, 4050-4058 (2004)
14. Zhang, Y., Ju, Y., Huang, C., Wysocki, V.H.: Paper spray ionization of noncovalent protein complexes. Anal. Chem. 86, 1342-1346 (2014)
15. Van Berkel, G.J.: Thin-layer chromatography and electrospray mass spectrometry coupled using a surface sampling probe. Anal. Chem. 74, 6216-6223 (2002)
16. Kertesz, V., Van Berkel, G.J.: Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform. J. Mass Spectrom. 45, 252-260 (2010)
17. Walworth, M.J., ElNaggar, S.M., Stankovich, J.J., Witkowski, W., Norris, J.L., Van Berkel, G.J.: Direct sampling and analysis from solid-phase extraction cards using an automated liquid extraction surface analysis nanoelectrospray mass spectrometry system. Rapid Commun. Mass Spectrom. 25, 2389-2396 (2011)
18. Stegemann, C., Drozdov, I., Shalhoub, J., Humphries, J., Ladroue, C., Didangelos, A., Baumert, M., Allen, M., Davies, A.H., Monaco, C., Smith, A., Xu, Q., Mayr, M.: Comparative lipidomics profiling of human atherosclerotic plaques. Circ. Cardiovasc. Genet. 4, 232-242 (2011)
19. Walworth, M.J., Stankovich, J.J., Van Berkel, G.J., Schulz, M., Minarik, S.: High-performance thin-layer chromatography plate blotting for liquid microjunction surface sampling probe mass spectrometric analysis of analytes separated on a wettable phase plate. Rapid Commun. Mass Spectrom. 36, 37-42 (2012)
20. Sarsby, J., Martin, N.J., Lalor, P.F., Bunch, J., Cooper, H.J.: Top down and bottom up identification of proteins by liquid extraction surface analysis mass spectrometry of healthy and diseased human liver tissue. J. Am. Mass Spectrom. 25, 1953-1961 (2014)
21. Edwards, R.L., Creese, A.J., Baumert, M., Griffiths, P., Bunch, J., Cooper, H.J.: Hemoglobin variant analysis via direct surface sampling of dried blood spots coupled with high-resolution mass spectrometry. Anal. Chem. 83, 2265-2270 (2011)
22. Schey, K.L., Anderson, D.M., Rose, K.L.: Spatially directed protein identification from tissue sections by top down LC-MS/MS with electron transfer dissociation. Anal. Chem. 85, 6767-6774 (2013)
23. Randall, E.C., Bunch, J., Cooper, H.J.: Direct analysis of intact proteins from Escherichia coli colonies by liquid extraction surface analysis mass spectrometry. Anal. Chem. 86, 10504 (2014)
24. Arakawa, T., Prestrelski, S.J., Kenney, W.C., Carpenter, J.F.: Factors affecting short-term and long-term stabilities of proteins. Adv. Drug Deliv. Rev. 46, 307-326 (2001)
25. Sowemimo-Coker, S.: Red blood cell hemolysis during processing. Transfus. Med. Rev. 16, 46-60 (2002)
26. Kanias, T., Acker, J.P.: Biopreservation of red blood cells the struggle with hemoglobin oxidation. FEBS Lett. 277, 343-356 (2010)
27. Marshall, W.J., Bangert, S.K.: Clinical Chemistry, 6th edn. Elsevier, Edinburgh, pp. 395-396 (2008)
28. Adach, K., Zhao, Y., Surrey, S.: Assembly of human hemoglobin (Hb) and globin chains expressed in a cell-free system with globin chains to form Hb A and Hb F. J. Biol. Chem. 277, 13415-13420 (2002)
29. Benesch, J.L.P., Sobott, F., Robinson, C.V.: Thermal dissociation of multimeric protein complexes by using nanoelectrospray mass spectrometry. Anal. Chem. 75, 2208-2214 (2003)
30. Moulin, A.M., O'Shea, S.J., Badley, R.A., Doyle, P., Welland, M.E.: Measuring surface induced conformational changes in proteins. Langmuir 15, 8776-8779 (1999)
31. Moini, M.: Metal displacement and stoichiometry of protein-metal complexes under native conditions using capillary electrophoresis/mass spectrometry. Rapid Commun. Mass Spectrom. 24, 2730-2734 (2010)
32. Pan, J., Xu, K., Yang, X., Choy, W.Y., Konermann, L.: Solution phase chelators for suppressing nonspecific protein-metal interactions in electrospray mass spectrometry. Anal. Chem. 81, 5008-5015 (2009)
33. Simmons, D.A., Wilson, D.J., Lajoie, G.A., Doherty-Kirby, A., Konermann, L.: Subunit disassembly and unfolding kinetics of hemoglobin studied by time-resolved electrospray mass spectrometry. Biochemistry 43, 14792-14801 (2004)
34. Griffith, W.P., Kaltashov, I.A.: Highly asymmetric interactions between globin chains during hemoglobin assembly revealed by electrospray ionization mass spectrometry. Biochemistry 42, 10024-10033 (2003)
35. Lössl, P., Snijder, J., Heck, A.J.: Boundaries of mass resolution in native mass spectrometry. J. Am. Mass Spectrom. 25, 906-917 (2014)
36. Veenstra, T.D., Tomlinson, A.J., Benson, L., Kumar, R., Naylor, S.: Low temperature aqueous electrospray ionization mass spectrometry of noncovalent complexes. J. Am. Soc. Mass Spectrom. 9, 580-584 (1998)
37. Loo, R.O., Goodlett, D.R., Smith, R.D., Loo, J.A.: Observation of a noncovalent ribonuclease s-protein/s-peptide complex by electrospray ionization mass spectrometry. J. Am. Chem. Soc. 115, 4391-4392 (1993)
38. WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization, (2011). Available at: http://www.who.int/vmnis/indicators/haemoglobin.pdf. Accessed 2 Feb 2014
39. Muncie, H.L., Campbell, S.J.: Alpha and Beta Thalassemia. Am. Fam. Physician 4, 339-344 (2009)