Alpha and beta thalassemia

American Family Physician

Volumn 80, Issue 4, 2009, Pages

  Muncie Jr , Herbert L ^a,b   Campbell, James S ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFERASIROX; DEFEROXAMINE; DEFEROXAMINE MESYLATE; FOLIC ACID; GROWTH HORMONE; HEMOGLOBIN; LOW MOLECULAR WEIGHT HEPARIN; PENICILLIN G; PNEUMOCOCCUS VACCINE;

ALPHA THALASSEMIA; BETA THALASSEMIA; BLOOD TRANSFUSION; BONE MARROW TRANSPLANTATION; CHROMOSOME 16; FOLIC ACID DEFICIENCY; GASTROINTESTINAL SYMPTOM; GENETIC VARIABILITY; GROWTH DISORDER; HEMOGLOBINOPATHY; HORMONAL THERAPY; HUMAN; HYPERSPLENISM; HYPOGONADISM; IRON DEFICIENCY; IRON OVERLOAD; JAUNDICE; OSTEOPENIA; OSTEOPOROSIS; PATHOPHYSIOLOGY; PREGNANCY; PSYCHIATRIC TREATMENT; REVIEW; SEPSIS; SKELETON MALFORMATION; SPLENECTOMY; SPLENOMEGALY; THROMBOSIS;

EID: 69749110598     PISSN: 0002838X     EISSN: 0002838X     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Whipple GH, Bradford WL. Mediterranean disease: thalassemia (erythroblastic anemia of Cooley). J Pediatr. 1936;9:279-311.
2. Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med. 2005;353(11):1135-1146.
3. Richardson M. Microcytic anemia [published corrections appear in Pediatr Rev. 2007;28(4):151, and Pediatr Rev. 2007;28(7):275]. Pediatr Rev. 2007;28(1):5-14.
4. Chui DH, Fucharoen S, Chan V. Hemoglobin H disease: not necessarily a benign disorder. Blood. 2003;101(3):791-800. (Pubitemid 36139341)
5. Chui DH, Waye JS. Hydrops fetalis caused by alpha-thalassemia: an emerging health care problem. Blood. 1998;91(7):2213-2222.
6. Olivieri NF. The beta-thalassemias [published correction appears in N Engl J Med. 1999;341(18):1407]. N Engl J Med. 1999;341(2):99-109.
7. Mentzer WC Jr. Differentiation of iron deficiency from thalassaemia trait. Lancet. 1973;1(7808):882.
8. Flynn MM, Reppun TS, Bhagavan NV. Limitations of red blood cell distribution width (RDW) in evaluation of microcytosis. Am J Clin Pathol. 1986;85(4):445-449. (Pubitemid 16052950)
9. Marsh WL Jr, Bishop JW, Darcy TP. Evaluation of red cell volume distribution width (RDW). Hematol Pathol. 1987;1(2):117-123. (Pubitemid 18170927)
10. Guyatt GH, Oxman AD, Ali M, Willan A, McIlroy W, Patterson C. Laboratory diagnosis of iron-deficiency anemia: an overview [published correction appears in J Gen Intern Med. 1992;7(4):423]. J Gen Intern Med. 1992;7(2):145-153.
11. Modell B, Khan M, Darlison M. Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet. 2000;355(9220):2051-2052. (Pubitemid 30339248)
12. Eldor A, Rachmilewitz EA. The hypercoagulable state in thalassemia. Blood. 2002;99(1):36-43.
13. Cappellini MD, Robbiolo L, Bottasso BM, Coppola R, Fiorelli G, Mannucci AP. Venous thromboembolism and hypercoagulability in splenectomized patients with thalassaemia intermedia. Br J Haematol. 2000;111(2):467-473. (Pubitemid 32009338)
14. Jensen CE, Tuck SM, Agnew JE, et al. High prevalence of low bone mass in thalassaemia major. Br J Haematol. 1998;103(4):911-915.
15. Cazzola M, Borgna-Pignatti C, Locatelli F, Ponchio L, Beguin Y, De Stefano P. A moderate transfusion regimen may reduce iron loading in beta-thalassemia major without producing excessive expansion of erythropoiesis. Transfusion. 1997;37(2):135-140. (Pubitemid 27091897)
16. Roberts DJ, Brunskill SJ, Doree C, Williams S, Howard J, Hyde CJ. Oral deferiprone for iron chelation in people with thalassaemia. Cochrane Database Syst Rev. 2007;(3):CD004839. (Pubitemid 351805588)
17. Deferasirox (Exjade): a new iron chelator. Med Lett Drugs Ther. 2006;48(1233):35-36. (Pubitemid 351639916)
18. Borgna-Pignatti C. Modern treatment of thalassaemia intermedia. Br J Haematol. 2007;138(3):291-304.
19. De Sanctis V. Growth and puberty and its management in thalassaemia. Horm Res. 2002;58(suppl 1):72-79. (Pubitemid 35316841)
20. ACOG Committee on Obstetrics. ACOG practice bulletin no. 78: hemoglobinopathies in pregnancy. Obstet Gynecol. 2007;109(1):229-237.
21. Braude P, Pickering S, Flinter F, Ogilvie CM. Preimplantation genetic diagnosis [published correction appears in Nat Rev Genet. 2003;4(2):157]. Nat Rev Genet. 2002;3(12):941-953.
22. Hoffbrand AV, Cohen A, Hershko C. Role of deferiprone in chelation therapy for transfusional iron overload. Blood. 2003;102(1):17-24. (Pubitemid 36759630)
23. Brittenham GM, Cohen AR, McLaren CE, et al. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol. 1993;42(1):81-85.
24. Anie KA, Massaglia P. Psychological therapies for thalassaemia. Cochrane Database Syst Rev. 2001;(3):CD002890.