In vitro fermentation of anthocyanins encapsulated with cyclodextrins: Release, metabolism and influence on gut microbiota growth

Journal of Functional Foods

Volumn 16, Issue , 2015, Pages 50-57

  Flores, Gema ^a,b   Ruiz del Castillo, María Luisa ^a   Costabile, Adele ^b   Klee, Anna ^b   Bigetti Guergoletto, Karla ^b,c   Gibson, Glenn R ^b  

^a INSTITUTE OF FOOD SCIENCE   (Spain)

^b UNIVERSITY OF READING   (United Kingdom)

^c STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Anthocyanins; Cyclodextrin; Gut microbiota; Microbial metabolism; Phenolic acids; Short chain fatty acids

Indexed keywords

BACTERIA (MICROORGANISMS); CLOSTRIDIUM HISTOLYTICUM;

EID: 84937553427     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.04.022     Document Type: Article

References (35)

1. Ávila M., Hidalgo M., Sánchez-Moreno C., Pelaez C., Requena M.T., de Pascual-Teresa S. Bioconversion of anthocyanin glycosides by Bifidobacterium and Lactobacillus. Food Research International 2009, 42:1453-1461.
2. Aceituno-Medina M., Mendoza S., Rodríguez B.A., Lagaron J.M., López-Rubio A. Improved antioxidant capacity of quercetin and ferulic acid during in-vitro digestion through encapsulation within food-grade electrospun fibers. Journal of Functional Foods 2015, 12:332-341.
3. Bourvellec C. Association entre les procyanidols et les polymères pariétaux depommes: Quantification et conséquences. Universite de Rennes I: (Vol. Docteur) 2003.
4. Czank C., Cassidy A., Zhang Q., Morrison D.J., Preston T., Kroon P.A., Botting N.P., Kay C.D. Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: A (13)C-tracer study. American Journal of Clinical Nutrition 2013, 97:995-1003.
5. Daims H., Bruhl A., Amann R., Schleifer K.H., Wagner M. The domain-specific probe EUB338 is insufficient for the detection of all Bacteria: Development and evaluation of a more comprehensive probe set. Systematic & Applied Microbiology 1999, 22(3):434-444.
6. Dangles O., Wigand M.C., Brouillard R. Anthocyanin anti-copigment effect. Phytochemistry 1992, 31(11):3811-3812.
7. Del Valle E.M.M. Cyclodextrins and their uses: A review. Process Biochemistry 2004, 39(9):1033-1046.
8. Desai K.G.H., Park H.J. Recent developments in microencapsulation of food ingredients. Drying Technology 2005, 23:1361-1394.
9. Fernandes A., Sousa A., Azevedo J., Mateus N., de Freitas V. Effect of cyclodextrins on the thermodynamic and kinetic properties of cyanidin-3-O-glucoside. Food Research International 2013, 51:748-755.
10. Ferreira D.S., Faria A.F., Grosso C.R.F., Mercadante A.Z. Encapsulation of blackberry anthocyanins by thermal gelation of curdlan. Journal of Brazilian Chemical Society 2009, 20:1908-1915.
11. Fleschhut J., Kratzer F., Rechkemmer G., Kulling S.E. Stability and biotransformation of various dietary anthocyanins in vitro. European Journal of Nutrition 2006, 45(1):7-18.
12. Forester S.C., Waterhouse A.L. Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells. Journal of Agricultural & Food Chemistry 2010, 58(9):5320-5327.
13. Franks A.H., Harmsen H.J., Raangs G.C., Jansen G.J., Schut F., Welling G.W. Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Applied & Environmental Microbiology 1998, 64(9):3336-3345.
14. Gibson G.R. Prebiotics as gut microflora management tools. Journal of Clinical Gastroenterology 2008, 42:75-79.
15. Harmsen H.J.M., Rangs G.C., He T., Degener J.E., Welling G.W. Extensive set of 16S rRNA-based probes for detection of bacteria in human feces. Applied & Environmental Microbiology 2002, 68:2982-2990.
16. He J., Giusti M.M. Anthocyanins: Natural colorants with health-promoting properties. Annual Review of Food Science and Technology 2010, 1:163-187.
17. Hidalgo M., Oruna-Concha M.J., Kolida S., Walton G.E., Kallithraka S., Spencer J.P., de Pascual-Teresa S. Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth. Journal of Agricultural & Food Chemistry 2012, 60(15):3882-3890.
18. Hughes R., Magee E.A.M., Bingham S. Protein degradation in the large intestine: Relevance to colorectal cancer. Current Issues in Intestinal Microbiology 2000, 1:51-58.
19. Kassinen A., Krogius-Kurikka L., Makivuokko H., Rinttila T., Paulin L., Corander J., Malinen E., Apajalahti J., Palva A. The faecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 2007, 133(1):24-33.
20. Kosaraju S.L. Colon targeted delivery systems: Review of polysaccharides for encapsulation and delivery. Critical Reviews in Food Science & Nutrition 2005, 45(4):251-258.
21. Langendijk P.S., Schut F., Jansen G.J., Raangs G.C., Kamphuis G.R., Wilkinson M.H., Welling G.W. Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in faecal samples. Applied & Environmental Microbiology 1995, 61(8):3069-3075.
22. Lin H.V., Frassetto A., Kowalik E.J., Nawrocki A.R., Lu M.M., Kosinski J.R., Hubert J.A., Szeto D., Yao X., Forrest G., Marsh D.J. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS ONE 2012, 7(4):e35240.
23. Lozupone C.A., Stombaugh J.I., Gordon J.I., Jansson J.K., Knight R. Diversity, stability and resilience of the human gut microbiota. Nature 2012, 489(7415):220-230.
24. Manz W., Amann R., Ludwig W., Vancanneyt M., Schleifer K.H. Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment. Microbiology (Reading, England) 1996, 142(Pt. 5):1097-1106.
25. Martín A., Mattea F., Gutierrez L., Miguel F., Cocero M.J. Co-precipitation of carotenoids and biopolymers with the supercritical anti-solvent process. Journal of Supercritical Fluids 2007, 41:138-147.
26. Martín-Peláez S., Gibson G.R., Martin-Orúe S.M., Klinder A., Rastall R.A., La Ragione R.M., Woodward M.J., Costabile A. In vitro fermentation of carbohydrates by porcine faecal inocula and their influence on Salmonella Typhimurium growth in batch culture systems. FEMS Microbiology Ecology 2008, 66:608-619.
27. Norberto S., Silva S., Meireles M., Faria A., Pintado M., Calhau C. Blueberry anthocyanins in health promotion: A metabolic overview. Journal of Functional Foods 2013, 5(4):1518-1528.
28. Pryde S.E., Duncan S.H., Hold G.L., Stewart C.S., Flint H.J. The microbiology of butyrate formation in the human colon. FEMS Microbiology Letters 2002, 217(2):133-139.
29. Sanchez-Patán F., Cueva C., Monagas M., Walton G.E., Gibson G.R., Quintanilla-Lopez J.E., Lebron-Aguilar R., Martin-Alvarez P.J., Moreno-Arribas M.V., Bartolome B. In vitro fermentation of a red wine extract by human gut microbiota: Changes in microbial groups and formation of phenolic metabolites. Journal of Agricultural and Food Chemistry 2012, 60(9):2136-2147.
30. Tonon R.V., Brabet C., Hubinger M.D. Anthocyanin stability and antioxidant activity of spray-dried açaí (Euterpe oleracea Mart.) juice produced with different carrier agents. Food Research International 2010, 43:907-914.
31. Tsukahara T., Murakami-Murofushi K. Release of cyclic phosphatidic acid from gelatin-based hydrogels inhibit colon cancer cell growth and migration. Scientific Reports 2012, 2. Article number 00687.
32. Tzounis X., Vulevic J., Kuhnle G.G., George T., Leonczak J., Gibson G.R., Kwik-Uribe C., Spencer J.P. Flavanol monomer-induced changes to the human faecal microflora. British Journal of Nutrition 2008, 99(4):782-792.
33. Vitaglione P., Donnarumma G., Napolitano A., Galvano F., Gallo A., Scalfi L., Fogliano V. Protocatechuic acid is the major human metabolite of cyanidin-glucosides. Journal of Nutrition 2007, 137(9):2043-2048.
34. Woodward G., Kroon P., Cassidy A., Kay C. Anthocyanin stability and recovery: Implications for the analysis of clinical and experimental samples. Journal of Agricultural and Food Chemistry 2009, 57(12):5271-5278.
35. Zafra-Stone S., Yasmin T., Bagchi M., Chatterjee A., Vinson J.A., Bagchi D. Berry anthocyanins as novel antioxidants in human health and disease prevention. Molecular Nutrition & Food Research 2007, 51(6):675-683.