The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase II containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

Acta Crystallographica Section D: Biological Crystallography

Volumn 71, Issue , 2015, Pages 1555-1563

  Klima, Martin ^a   Baumlova, Adriana ^a   Chalupska, Dominika ^a   Hřebabecký, Hubert ^a   Dejmek, Milan ^a   Nencka, Radim ^a   Boura, Evzen ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

ATP; crystal structure; inhibitor; kinase; phosphatidyl inositol

Indexed keywords

EUKARYOTA;

ADENOSINE TRIPHOSPHATE; ISOPROTEIN; NUCLEOSIDE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE INHIBITOR;

ANTAGONISTS AND INHIBITORS; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DESIGN; ENZYME ACTIVE SITE; HUMAN; METABOLISM; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ADENOSINE TRIPHOSPHATE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NUCLEOSIDES; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS;

EID: 84937547552     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004715009505     Document Type: Article

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