Redox-regulated suppression of Splenic T-lymphocyte activation in a model of sympathoexcitation

Hypertension

Volumn 65, Issue 4, 2015, Pages 916-923

  Case, Adam J ^a   Zimmerman, Matthew C ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

cardiovascular disease; hypertension; immunosuppression; inflammation; norepinephrine; reactive oxygen species; superoxide

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN E; CYCLIN E1; CYCLIN E2; GAMMA INTERFERON; LIPOCORTIN 5; MESSENGER RNA; NORADRENALIN; PROPIDIUM IODIDE; SUPEROXIDE; TEMPOL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADRENERGIC RECEPTOR STIMULATING AGENT; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CYCLE ARREST; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; G1 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HYPERTENSION; IMMUNE DEFICIENCY; IMMUNOPHENOTYPING; IN VIVO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; NORADRENALIN BLOOD LEVEL; NORADRENALIN URINE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEADY STATE; SYMPATHETIC FUNCTION; SYMPATHETIC HYPERACTIVATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ADRENERGIC SYSTEM; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE ACTIVATION; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; HYPERTENSION; IMMUNOSUPPRESSION; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; NOREPINEPHRINE; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOMIMETICS; T-LYMPHOCYTES;

EID: 84937544479     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.05075     Document Type: Article

References (37)

1. Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci. 2006; 7: 335-346. doi: 10.1038/nrn1902
2. Osborn JW, Fink GD. Region-specific changes in sympathetic nerve activity in angiotensin II-salt hypertension in the rat. Exp Physiol. 2010; 95: 61-68. doi: 10.1113/expphysiol.2008.046326
3. Zucker IH. Novel mechanisms of sympathetic regulation in chronic heart failure. Hypertension. 2006; 48: 1005-1011. doi: 10.1161/01. HYP.0000246614.47231.25
4. Walter U, Kolbaske S, Patejdl R, Steinhagen V, Abu-Mugheisib M, Grossmann A, Zingler C, Benecke R. Insular stroke is associated with acute sympathetic hyperactivation and immunodepression. Eur J Neurol. 2013; 20: 153-159. doi: 10.1111/j.1468-1331.2012.03818.x
5. Liu JL, Zucker IH. Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II. Circ Res. 1999; 84: 417-423
6. Mathias CJ. Role of sympathetic efferent nerves in blood pressure regulation and in hypertension. Hypertension. 1991; 18(5 Suppl): III22-III30
7. Grassi G. Role of the sympathetic nervous system in human hypertension. J Hypertens. 1998; 16: 1979-1987
8. Crowley SD, Song YS, Lin EE, Griffiths R, Kim HS, Ruiz P. Lymphocyte responses exacerbate angiotensin II-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2010; 298: R1089-R1097. doi: 10.1152/ajpregu.00373.2009
9. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007; 204: 2449-2460. doi: 10.1084/jem.20070657
10. Sanders VM. The role of adrenoceptor-mediated signals in the modulation of lymphocyte function. Adv Neuroimmunol. 1995; 5: 283-298
11. Nance DM, Sanders VM. Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun. 2007; 21: 736-745. doi: 10.1016/j.bbi.2007.03.008
12. Martelli D, Yao ST, McKinley MJ, McAllen RM. Reflex control of inflammation by sympathetic nerves, not the vagus. J Physiol. 2014; 592(Pt 7): 1677-1686. doi: 10.1113/jphysiol.2013.268573
13. Mracsko E, Liesz A, Karcher S, Zorn M, Bari F, Veltkamp R. Differential effects of sympathetic nervous system and hypothalamic-pituitary-adrenal axis on systemic immune cells after severe experimental stroke. Brain Behav Immun. 2014; 41: 200-209. doi: 10.1016/j.bbi.2014.05.015
14. Vahdat K, Pourbehi MR, Ostovar A, Hadavand F, Bolkheir A, Assadi M, Farrokhnia M, Nabipour I. Association of pathogen burden and hypertension: the Persian Gulf Healthy Heart Study. Am J Hypertens. 2013; 26: 1140-1147. doi: 10.1093/ajh/hpt083
15. Rosenne E, Sorski L, Shaashua L, Neeman E, Matzner P, Levi B, Ben-Eliyahu S. In vivo suppression of NK cell cytotoxicity by stress and surgery: glucocorticoids have a minor role compared to catecholamines and prostaglandins. Brain Behav Immun. 2014; 37: 207-219. doi: 10.1016/j. bbi.2013.12.007
16. Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, Weyand C, Gordon FJ, Harrison DG. Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ Res. 2010; 107: 263-270. doi: 10.1161/CIRCRESAHA.110.217299
17. James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014; 311: 507-520. doi: 10.1001/jama.2013.284427
18. Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ. Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation. 2010; 122: 2529-2537. doi: 10.1161/CIRCULATIONAHA.109.930446
19. Krishan A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol. 1975; 66: 188-193
20. Boonstra J. Progression through the G1-phase of the on-going cell cycle. J Cell Biochem. 2003; 90: 244-252. doi: 10.1002/jcb.10617
21. Schraml E, Quan P, Stelzer I, Fuchs R, Skalicky M, Viidik A, Schauenstein K. Norepinephrine treatment and aging lead to systemic and intracellular oxidative stress in rats. Exp Gerontol. 2007; 42: 1072-1078. doi: 10.1016/j. exger.2007.08.003
22. Xiong F, Xiao D, Zhang L. Norepinephrine causes epigenetic repression of PKCε gene in rodent hearts by activating Nox1-dependent reactive oxygen species production. FASEB J. 2012; 26: 2753-2763. doi: 10.1096/fj.11-199422
23. Deo SH, Jenkins NT, Padilla J, Parrish AR, Fadel PJ. Norepinephrine increases NADPH oxidase-derived superoxide in human peripheral blood mononuclear cells via α-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol. 2013; 305: R1124-R1132. doi: 10.1152/ajpregu.00347.2013
24. Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassègue B, Griendling KK, Harrison DG, Dikalova AE. Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxid Redox Signal. 2014; 20: 281-294. doi: 10.1089/ars.2012.4918
25. Padro CJ, Sanders VM. Neuroendocrine regulation of inflammation. Semin Immunol. 2014; 26: 357-368. doi: 10.1016/j.smim.2014.01.003
26. Feldman RD, Hunninghake GW, McArdle WL. Beta-adrenergic-receptormediated suppression of interleukin 2 receptors in human lymphocytes. J Immunol. 1987; 139: 3355-3359
27. Takayanagi Y, Osawa S, Ikuma M, Takagaki K, Zhang J, Hamaya Y, Yamada T, Sugimoto M, Furuta T, Miyajima H, Sugimoto K. Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β1 adrenoceptor. J Neuroimmunol. 2012; 245: 66-74. doi: 10.1016/j.jneuroim.2012.02.007
28. Ramer-Quinn DS, Swanson MA, Lee WT, Sanders VM. Cytokine production by naive and primary effector CD4+ T cells exposed to norepinephrine. Brain Behav Immun. 2000; 14: 239-255. doi: 10.1006/brbi.2000.0603
29. Sheridan JF, Dobbs C, Jung J, Chu X, Konstantinos A, Padgett D, Glaser R. Stress-induced neuroendocrine modulation of viral pathogenesis and immunity. Ann N Y Acad Sci. 1998; 840: 803-808
30. Alaniz RC, Thomas SA, Perez-Melgosa M, Mueller K, Farr AG, Palmiter RD, Wilson CB. Dopamine beta-hydroxylase deficiency impairs cellular immunity. Proc Natl Acad Sci USA. 1999; 96: 2274-2278
31. Swanson MA, Lee WT, Sanders VM. IFN-gamma production by Th1 cells generated from naive CD4+ T cells exposed to norepinephrine. J Immunol. 2001; 166: 232-240
32. Madden KS, Moynihan JA, Brenner GJ, Felten SY, Felten DL, Livnat S. Sympathetic nervous system modulation of the immune system. III. Alterations in T and B cell proliferation and differentiation in vitro following chemical sympathectomy. J Neuroimmunol. 1994; 49: 77-87
33. Ramer-Quinn DS, Baker RA, Sanders VM. Activated T helper 1 and T helper 2 cells differentially express the beta-2-adrenergic receptor: a mechanism for selective modulation of T helper 1 cell cytokine production. J Immunol. 1997; 159: 4857-4867
34. Maisel AS, Michel MC. Beta-adrenergic receptors in congestive heart failure: present knowledge and future directions. Cardiology. 1989; 76: 338-346
35. Trott DW, Harrison DG. The immune system in hypertension. Adv Physiol Educ. 2014; 38: 20-24. doi: 10.1152/advan.00063.2013
36. Sarsour EH, Kumar MG, Chaudhuri L, Kalen AL, Goswami PC. Redox control of the cell cycle in health and disease. Antioxid Redox Signal. 2009; 11: 2985-3011. doi: 10.1089/ARS.2009.2513
37. Schiffrin EL. Antioxidants in hypertension and cardiovascular disease. Mol Interv. 2010; 10: 354-362. doi: 10.1124/mi.10.6.4