Effect of seminal leukocytes on in vitro fertilization and intracytoplasmic sperm injection outcomes

Fertility and Sterility

Volumn 104, Issue 1, 2015, Pages 87-93

  Ricci, Giuseppe ^a,b   Granzotto, Marilena ^a   Luppi, Stefania ^a   Giolo, Elena ^a   Martinelli, Monica ^a   Zito, Gabriella ^b   Borelli, Massimo ^b  

^a INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Assisted reproductive technology; flow cytometry; ICSI; IVF; leukocytospermia

Indexed keywords

GONADORELIN AGONIST; GONADORELIN ANTAGONIST;

ADULT; ARTICLE; CONTROLLED STUDY; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; FLOW CYTOMETRY; HUMAN; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; LEUKOCYTE COUNT; LEUKOCYTOSPERMIA; MAJOR CLINICAL STUDY; MALE; OOCYTE RETRIEVAL; OUTCOME ASSESSMENT; PREGNANCY RATE; PRIORITY JOURNAL; SEMEN ABNORMALITY; SEMEN ANALYSIS; CYTOLOGY; LEUKOCYTE; PREGNANCY; PROCEDURES; PROSPECTIVE STUDY; SPERM; TRENDS;

ADULT; FEMALE; FERTILIZATION IN VITRO; FLOW CYTOMETRY; HUMANS; LEUKOCYTES; MALE; PREGNANCY; PREGNANCY RATE; PROSPECTIVE STUDIES; SEMEN; SPERM INJECTIONS, INTRACYTOPLASMIC;

EID: 84937524161     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2015.04.007     Document Type: Article

References (45)

1. H. Wolff Methods for the detection of male genital tract inflammation Andrologia 30 Suppl 1 1998 35 39
2. B. Zorn, I. Virant-Klun, and H. Meden-Vrtovec Semen granulocyte elastase: its relevance for the diagnosis and prognosis of silent genital tract inflammation Hum Reprod 15 2000 1978 1984
3. T. Lemkecher, S. Dartigues, J. Vaysse, O. Kulski, V. Barraud-Lange, L. Gattegno, and et al. Leucocytospermia, oxidative stress and male fertility: facts and hypotheses Gynecol Obstet Fertil 33 2005 2 10
4. T. Domes, K.C. Lo, E.D. Grober, J.B. Mullen, T. Mazzulli, and K. Jarvi The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters Fertil Steril 97 2012 1050 1055
5. S. Alshahrani, J. McGill, and A. Agarwal Prostatitis and male infertility J Reprod Immunol 100 2013 30 36
6. G. Ricci Leukocytospermia and ART K. Khaldoun Sharif, A. Coomarasamy, Assisted reproduction techniques: challenges and management options 2012 Wiley-Blackwell Chichester, UK 367 370
7. J. Konc, K. Kanyó, R. Kriston, B. Somoskoi, and S. Cseh Cryopreservation of embryos and oocytes in human assisted reproduction Biomed Res Int 2014 2014 307268
8. P.E. Levi Setti, E. Porcu, P. Patrizio, V. Vigiliano, R. de Luca, P. d'Aloja, and et al. Human oocyte cryopreservation with slow freezing versus vitrification. Results from the National Italian Registry data, 2007-2011 Fertil Steril 102 2014 90 95.e2
9. J. Cohen, R. Edwards, C. Fehilly, S. Fishel, J. Hewitt, J. Purdy, and et al. In vitro fertilization: a treatment for male infertility Fertil Steril 43 1985 422 432
10. H.H. Van der Ven, R.S. Jeyendran, M. Perez-Pelaez, S. Al-Hasani, K. Diedrich, and D. Krebs Leucospermia and the fertilizing capacity of spermatozoa Eur J Obstet Gynecol Reprod Biol 24 1987 49 52
11. L.M. Talbert, M.G. Hammond, J. Halme, M. O'Rand, J.G. Fryer, and R.D. Ekstrom Semen parameters and fertilization of human oocytes in vitro: a multivariable analysis Fertil Steril 48 1987 270 277
12. C. De Geyter, M. De Geyter, H.M. Behre, H.P. Schneider, and E. Nieschlag Peroxidase-positive round cells and microorganisms in human semen together with antibiotic treatment adversely influence the outcome of in-vitro fertilization and embryo transfer Int J Androl 17 1994 127 134
13. N. Sukcharoen, J. Keith, and D.S. Irvine Predicting the fertilizing potential of human sperm suspensions in vitro: importance of sperm morphology and leukocyte contamination Fertil Steril 63 1995 1293 1300
14. M. Vicino, G. Loverro, S. Simonetti, L. Mei, and L. Selvaggi The correlation between idiopathic leukocytospermia, embryo quality and outcome in the FIVET and ICSI procedures Minerva Ginecol 51 1999 413 420
15. S. Yilmaz, M. Koyuturk, G. Kilic, O. Alpak, and A. Aytoz Effects of leucocytospermia on semen parameters and outcomes of intracytoplasmic sperm injection Int J Androl 28 2005 337 342
16. M.J. Tomlinson, C.L. Barratt, A.E. Bolton, E.A. Lenton, H.B. Roberts, and I.D. Cooke Round cells and sperm fertilizing capacity: the presence of immature germ cells but not seminal leukocytes are associated with reduced success of in vitro fertilization Fertil Steril 58 1992 1257 1259
17. J.M. Moilanen, O. Carpén, and O. Hovatta Flow cytometric light scattering analysis, acrosome reaction, reactive oxygen species production and leukocyte contamination of semen preparation in prediction of fertilization rate in vitro Hum Reprod 13 1998 2568 2574
18. R. Henkel, G. Maass, M. Hajimohammad, R. Menkveld, T. Stalf, J. Villegas, and et al. Urogenital inflammation: changes of leucocytes and ROS Andrologia 35 2003 309 313
19. J.E. Lackner, I. Mark, K. Sator, J. Huber, and M. Sator Effect of leukocytospermia on fertilization and pregnancy rates of artificial reproductive technologies Fertil Steril 90 2008 869 871
20. V. Barraud-Lange, J.C. Pont, K. Pocate, C. Sifer, I. Cedrin-Durnerin, B. Fechtali, and et al. Seminal leukocytes are Good Samaritans for spermatozoa Fertil Steril 96 2011 1315 1319
21. S. Seshadri, B. Flanagan, G. Vince, and D.I. Lewis Jones Leucocyte subpopulations in the seminal plasma and their effects on fertilisation rates in an IVF cycle Andrologia 44 2012 396 400
22. M. Cavagna, J.B. Oliveira, C.G. Petersen, A.L. Mauri, L.F. Silva, F.C. Massaro, and et al. The influence of leukocytospermia on the outcomes of assisted reproductive technology Reprod Biol Endocrinol 10 2012 44
23. G. Ricci, G. Presani, S. Guaschino, R. Simeone, and S. Perticarari Leukocyte detection in human semen using flow cytometry Hum Reprod 15 2000 1329 1337
24. J. Villegas, M. Schulz, V. Vallejos, R. Henkel, W. Miska, and R. Sánchez Indirect immunofluorescence using monoclonal antibodies for the detection of leukocytospermia: comparison with peroxidase staining Andrologia 34 2002 69 73
25. J.A. Politch, H. Wolff, J.A. Hill, and D.J. Anderson Comparison of methods to enumerate white blood cells in semen Fertil Steril 60 1993 372 375
26. A. Fathy, S.J. Chen, N. Novak, H.C. Schuppe, G. Haidl, and J.P. Allam Differential leucocyte detection by flow cytometry improves the diagnosis of genital tract inflammation and identifies macrophages as proinflammatory cytokine-producing cells in human semen Andrologia 46 2014 1004 1012
27. World Health Organization WHO laboratory manual for the examination and processing of human semen 5th ed. 2010 WHO Geneva
28. T.G. Cooper, and B. Hellenkemper Improving precision in the assessment of round cell numbers in human semen Asian J Androl 12 2010 111 114
29. S. Perticarari, G. Ricci, M. Granzotto, R. Boscolo, C. Pozzobon, S. Guarnieri, and et al. A new multiparameter flow cytometric method for human semen analysis Hum Reprod 22 2007 485 494
30. G. Ricci, S. Perticarari, R. Boscolo, R. Simeone, M. Martinelli, L. Fischer-Tamaro, and et al. Leukocytospermia and sperm preparation - a flow cytometric study Reprod Biol Endocrinol 7 2009 128
31. G. Ricci, P. Bogatti, L. Fischer-Tamaro, E. Giolo, S. Luppi, M. Montico, and et al. Factor V Leiden and prothrombin gene G20210A mutation and in vitro fertilization: prospective cohort study Hum Reprod 26 2011 3068 3077
32. R Core Team R: a language and environment for statistical computing 2014 R Foundation for Statistical Computing Vienna
33. J.J. Faraway Extending the linear model with R: generalized linear, mixed effects and nonparametric regression models 2005 CRC London
34. M.J. Crawley Statistics: an introduction using R 2005 John Wiley and Sons West Sussex, UK
35. G. Wilkinson, and C.E. Rogers Symbolic description of factorial models for analysis of variance J R Stat Soc Ser C Appl Stat 22 1973 392 399
36. J.E. Lackner, E. Lakovic, T. Waldhör, G. Schatzl, and M. Marberger Spontaneous variation of leukocytospermia in asymptomatic infertile males Fertil Steril 90 2008 1757 1760
37. R.K. Sharma, A.E. Pasqualotto, D.R. Nelson, A.J. Thomas Jr., and A. Agarwal Relationship between seminal white blood cell counts and oxidative stress in men treated at an infertility clinic J Androl 22 2001 575 583
38. M. Punab, K. Loivukene, K. Kermes, and R. Mändar The limit of leukocytospermia from the microbiological viewpoint Andrologia 35 2003 271 278
39. R. Henkel, E. Kierspel, T. Stalf, C. Mehnert, R. Menkveld, H.R. Tinneberg, and et al. Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients Fertil Steril 83 2005 635 642
40. H. Wolff The biologic significance of white blood cells in semen Fertil Steril 63 1995 1143 1157
41. E.H. Yanushpolsky, J.A. Politch, J.A. Hill, and D.J. Anderson Is leukocytospermia clinically relevant? Fertil Steril 66 1996 822 825
42. H. Charbonneau, N.K. Tonks, K.A. Walsh, and E.H. Fischer The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase Proc Natl Acad Sci U S A 85 1988 7182 7186
43. D.L. Jaye, R.A. Bray, H.M. Gebel, W.A. Harris, and E.K. Waller Translational applications of flow cytometry in clinical practice J Immunol 188 2012 4715 4719
44. F. Venet, A. Lepape, and G. Monneret Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions Crit Care 15 2011 231
45. Deutsche Gesellschaft für Zytometrie. Flow cytometry core facilities. Available at: http://www.dgfz.org/?page-id=3377. Accessed April 26, 2015.