The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters

Fertility and Sterility

Volumn 97, Issue 5, 2012, Pages 1050-1055

  Domes, Trustin ^a   Lo, Kirk C ^a   Grober, Ethan D ^a   Mullen, John Brendan M ^a   Mazzulli, Tony ^a   Jarvi, Keith ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Bacteriospermia; DNA fragmentation index; semen parameters; seminal leukocytes

Indexed keywords

ARTICLE; BACTERIAL INFECTION; BACTERIOSPERMIA; CANADA; CELL STRUCTURE; CITROBACTER KOSERI; COHORT ANALYSIS; CONTROLLED STUDY; DNA FRAGMENTATION; DNA FRAGMENTATION INDEX; ELEVATED SEMINAL LEUKOCYTE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HUMAN; KLEBSIELLA PNEUMONIAE; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MALE GENITAL TRACT INFECTION; MALE GENITAL TRACT PARAMETERS; MALE INFERTILITY; MALE SUBFERTILITY; MORGANELLA MORGANII; PRIORITY JOURNAL; PROTEUS MIRABILIS; RETROSPECTIVE STUDY; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS AGALACTIAE;

ADULT; BACTERIAL INFECTIONS; CELL SHAPE; CHI-SQUARE DISTRIBUTION; DNA FRAGMENTATION; HUMANS; INCIDENCE; INFERTILITY, MALE; LEUKOCYTE COUNT; LEUKOCYTES; MALE; ONTARIO; PREVALENCE; RETROSPECTIVE STUDIES; SEMEN; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA;

EID: 84860327231     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.01.124     Document Type: Article

References (51)

1. T. Diemer, P. Huwe, M. Ludwig, E.W. Hauck, and W. Weidner Urogenital infection and sperm motility Andrologia 35 2003 283 287 (Pubitemid 37363518)
2. F.R. Ochsendorf Sexually transmitted infections: impact on male fertility Andrologia 40 2008 72 75 (Pubitemid 351379670)
3. C. Keck, C. Gerber-Schafer, A. Clad, C. Wilhelm, and M. Breckwoldt Seminal tract infections: impact on male fertility and treatment options Hum Reprod Update 4 1998 891 903 (Pubitemid 29082477)
4. J.A. Andrada, F.E. Von der Walde, and E.C. Andrada Immunologic studies of male infertility Immunol Ser 52 1990 345 378
5. W. Weidner, C. Garbe, L. Weissbach, J. Harbrecht, K. Kleinschmidt, and H.G. Schiefer [Initial therapy of acute unilateral epididymitis using ofloxacin. I. Clinical and microbiological findings] Urologe A 29 1990 272 276 (Pubitemid 20330374)
6. G. Ludwig, and J. Haselberger [Epididymitis and fertility. Treatment results in acute unspecific epididymitis] Fortschr Med 95 1977 397 399 (Pubitemid 8034464)
7. H. Giamarellou, K. Tympanidis, N.A. Bitos, E. Leonidas, and G.K. Daikos Infertility and chronic prostatitis Andrologia 16 1984 417 422 (Pubitemid 15205119)
8. R. Henkel, M. Ludwig, H.C. Schuppe, T. Diemer, W.B. Schill, and W. Weidner Chronic pelvic pain syndrome/chronic prostatitis affect the acrosome reaction in human spermatozoa World J Urol 24 2006 39 44 (Pubitemid 43298682)
9. R. Menkveld Leukocytospermia S. Daya, R. Harrison, R. Kempers, Advances in fertility and reproductive medicine International Congress Series No 1266 2004 Elsevier Amsterdam 218 224
10. C.E. Close, P.L. Roberts, and R.E. Berger Cigarettes, alcohol and marijuana are related to pyospermia in infertile men J Urol 144 1990 900 903 (Pubitemid 20324812)
11. C.L. Barratt, A.E. Bolton, and I.D. Cooke Functional significance of white blood cells in the male and female reproductive tract Hum Reprod 5 1990 639 648 (Pubitemid 20308437)
12. K. Jarvi, and M.B. Noss Pyospermia and male infertility Can J Urol 1 1994 25 30
13. P. Huwe, T. Diemer, M. Ludwig, J. Liu, H.G. Schiefer, and W. Weidner Influence of different uropathogenic microorganisms on human sperm motility parameters in an in vitro experiment Andrologia 30 Suppl 1 1998 55 59 (Pubitemid 28244194)
14. F.M. Kohn, I. Erdmann, T. Oeda, K.F. el Mulla, H.G. Schiefer, and W.B. Schill Influence of urogenital infections on sperm functions Andrologia 30 Suppl 1 1998 73 80 (Pubitemid 28244196)
15. F.F. Pasqualotto, R.K. Sharma, D.R. Nelson, A.J. Thomas, and A. Agarwal Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation Fertil Steril 73 2000 459 464 (Pubitemid 30109638)
16. R.K. Sharma, and A. Agarwal Role of reactive oxygen species in male infertility Urology 48 1996 835 850 (Pubitemid 26427090)
17. M.H. Moustafa, R.K. Sharma, J. Thornton, E. Mascha, M.A. Abdel-Hafez, and A.J. Thomas Jr. Relationship between ROS production, apoptosis and DNA denaturation in spermatozoa from patients examined for infertility Hum Reprod 19 2004 129 138 (Pubitemid 38072021)
18. T.G. Cooper, W. Weidner, and E. Nieschlag The influence of inflammation of the human male genital tract on secretion of the seminal markers alpha-glucosidase, glycerophosphocholine, carnitine, fructose and citric acid Int J Androl 13 1990 329 336 (Pubitemid 20331769)
19. G.F. Gonzales, G. Kortebani, and A.B. Mazzolli Leukocytospermia and function of the seminal vesicles on seminal quality Fertil Steril 57 1992 1058 1065
20. J.P. Jarow, J.A. Kirkland Jr., and D.G. Assimos Association of antisperm antibodies with chronic nonbacterial prostatitis Urology 36 1990 154 156 (Pubitemid 20239026)
21. D.A. Gubin, R. Dmochowski, and W.H. Kutteh Multivariant analysis of men from infertile couples with and without antisperm antibodies Am J Reprod Immunol 39 1998 157 160 (Pubitemid 28062288)
22. D.G. Dimitrov, V. Urbanek, J. Zverina, J. Madar, K. Nouza, and R. Kinsky Correlation of asthenozoospermia with increased antisperm cell-mediated immunity in men from infertile couples J Reprod Immunol 27 1994 3 12 (Pubitemid 24275710)
23. C. Bohring, and W. Krause The role of antisperm antibodies during fertilization and for immunological infertility Chem Immunol Allergy 88 2005 15 26 (Pubitemid 43094375)
24. A.E. Omu, F. Al-Qattan, F.M. Al-Abdul-Hadi, M.T. Fatinikun, and S. Fernandes Seminal immune response in infertile men with leukocytospermia: effect on antioxidant activity Eur J Obstet Gynecol Reprod Biol 86 1999 195 202 (Pubitemid 29391486)
25. N. Bar-Chama, and H. Fisch Infection and pyospermia in male infertility World J Urol 11 2 1993 76 81 (Pubitemid 23273281)
26. World Health Organization (WHO) Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction 4th ed. 1999 Cambridge University Press Cambridge
27. World Health Organization (WHO) Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction 3d ed. 1992 Cambridge University Press Cambridge
28. R.E. Berger, L.E. Karp, R.A. Williamson, J. Koehler, D.E. Moore, and K.K. Holmes The relationship of pyospermia and seminal fluid bacteriology to sperm function as reflected in the sperm penetration assay Fertil Steril 37 1982 557 564 (Pubitemid 12141843)
29. M.P. McGowan, H.G. Burger, H.W. Baker, D.M. deKrester, and G. Kovacs The incidence of non-specific infection in the semen in fertile and sub-fertile males Int J Androl 4 1981 657 662 (Pubitemid 12198138)
30. E. Cottell, R.F. Harrison, M. McCaffrey, T. Walsh, E. Mallon, and C. Barry-Kinsella Are seminal fluid microorganisms of significance or merely contaminants? Fertil Steril 74 2000 465 470
31. K. Jarvi, J.M. Lacroix, A. Jain, I. Dumitru, D. Heritz, and M.W. Mittelman Polymerase chain reaction-based detection of bacteria in semen Fertil Steril 66 1996 463 467 (Pubitemid 27009891)
32. J. Fowler Infections of the male reproductive tract and infertility: a selected review J Androl 3 1981 121 131
33. M.A. De Francesco, R. Negrini, G. Ravizzola, P. Galli, and N. Manca Bacterial species present in the lower male genital tract: a five-year retrospective study Eur J Contracept Reprod Health Care 16 2011 47 53
34. D.M. Rodin, D. Larone, and M. Goldstein Relationship between semen cultures, leukospermia, and semen analysis in men undergoing fertility evaluation Fertil Steril 79 Suppl 3 2003 1555 1558 (Pubitemid 36687932)
35. S. Bussen, M. Zimmermann, M. Schleyer, and T. Steck Relationship of bacteriological characteristics to semen indices and its influence on fertilization and pregnancy rates after IVF Acta Obstet Gynecol Scand 76 1997 964 968 (Pubitemid 27511476)
36. R. Gdoura, W. Kchaou, A. Znazen, N. Chakroun, M. Fourati, and L. Ammar-Keskes Screening for bacterial pathogens in semen samples from infertile men with and without leukocytospermia Andrologia 40 2008 209 218 (Pubitemid 352032754)
37. T. Balmelli, J. Stamm, M. Dolina-Giudici, R. Peduzzi, A. Piffaretti-Yanez, and M. Balerna Bacteroides ureolyticus in men consulting for infertility Andrologia 26 1994 35 38 (Pubitemid 24073576)
38. O. Gregoriou, D. Botsis, K. Papadias, D. Kassanos, A. Liapis, and P.A. Zourlas Culture of seminal fluid in infertile men and relationship to semen evaluation Int J Gynaecol Obstet 28 1989 149 153 (Pubitemid 19048390)
39. A. Naessens, W. Foulon, P. Debrucker, P. Devroey, and S. Lauwers Recovery of microorganisms in semen and relationship to semen evaluation Fertil Steril 45 1986 101 105 (Pubitemid 16137963)
40. N. Esfandiari, R.A. Saleh, M. Abdoos, A. Rouzrokh, and Z. Nazemian Positive bacterial culture of semen from infertile men with asymptomatic leukocytospermia Int J Fertil Womens Med 47 2002 265 270 (Pubitemid 36109482)
41. S.I. Moskovtsev, I. Lecker, J.B. Mullen, K. Jarvi, J. Willis, and J. White Cause-specific treatment in patients with high sperm DNA damage resulted in significant DNA improvement Syst Biol Reprod Med 55 2009 109 115
42. J. Lackner, G. Schatzl, S. Horvath, C. Kratzik, and M. Marberger Value of counting white blood cells (WBC) in semen samples to predict the presence of bacteria Eur Urol 49 2006 148 152 discussion 52-3 (Pubitemid 41789971)
43. H. Wolff The biologic significance of white blood cells in semen Fertil Steril 63 1995 1143 1157
44. E.H. Yanushpolsky, J.A. Politch, J.A. Hill, and D.J. Anderson Is leukocytospermia clinically relevant? Fertil Steril 66 1996 822 825 (Pubitemid 26357589)
45. J. Thomas, S.B. Fishel, J.A. Hall, S. Green, T.A. Newton, and S.J. Thornton Increased polymorphonuclear granulocytes in seminal plasma in relation to sperm morphology Hum Reprod 12 1997 2418 2421 (Pubitemid 27522200)
46. S.I. Moskovtsev, J. Willis, J. White, and J.B. Mullen Leukocytospermia: relationship to sperm deoxyribonucleic acid integrity in patients evaluated for male factor infertility Fertil Steril 88 2007 737 740 (Pubitemid 47368219)
47. J.E. Lackner, R. Herwig, J. Schmidbauer, G. Schatzl, C. Kratzik, and M. Marberger Correlation of leukocytospermia with clinical infection and the positive effect of antiinflammatory treatment on semen quality Fertil Steril 86 2006 601 605 (Pubitemid 44307003)
48. P. Piomboni, L. Gambera, F. Serafini, G. Campanella, G. Morgante, and V. De Leo Sperm quality improvement after natural anti-oxidant treatment of asthenoteratospermic men with leukocytospermia Asian J Androl 10 2008 201 206 (Pubitemid 351337980)
49. R. Menkveld, and T.F. Kruger Sperm morphology and male urogenital infections Andrologia 30 Suppl 1 1998 49 53 (Pubitemid 28244193)
50. M. Punab, K. Loivukene, K. Kermes, and R. Mandar The limit of leucocytospermia from the microbiological viewpoint Andrologia 35 2003 271 278 (Pubitemid 37363516)
51. K.K. Shy, M.A. Stenchener, and C.H. Muller Sperm penetration assay and subsequent pregnancy: a prospective study of 74 infertile men Obstet Gynecol 71 1998 685 690