High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the tumour-initiating properties of colon cancer stem cells

Journal of Pathology

Volumn 236, Issue 4, 2015, Pages 479-490

  Puglisi, Maria Ausiliatrice ^a   Cenciarelli, Carlo ^b   Tesori, Valentina ^a   Cappellari, Marianna ^c   Martini, Maurizio ^d   Di Francesco, Angela Maria ^a   Giorda, Ezio ^e   Carsetti, Rita ^e   Ricci Vitiani, Lucia ^c   Gasbarrini, Antonio ^a  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^b INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

^e BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

cancer stem cells; CD133; colon cancer; iNOS; nitric oxide

Indexed keywords

BETA CATENIN; CD133 ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR RELA; WNT PROTEIN; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; NOS2 PROTEIN, HUMAN; PEPTIDE; TUMOR MARKER;

ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CANCER STEM CELL; CARCINOGENICITY; CELL ADHESION; CELL FRACTIONATION; CELL INVASION; CELL MIGRATION; CELL SUBPOPULATION; COLON CANCER; COLON CARCINOGENESIS; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE SILENCING; HCT116 CELL LINE; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; CACO 2 CELL LINE; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HT 29 CELL LINE; METABOLISM; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; TIME; TUMOR VOLUME; UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; CACO-2 CELLS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HCT116 CELLS; HEK293 CELLS; HT29 CELLS; HUMANS; MICE, NUDE; NEOPLASTIC STEM CELLS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84937523330     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4545     Document Type: Article

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