Isolation and characterization of CD 133+ cell population within human primary and metastatic colon cancer

European Review for Medical and Pharmacological Sciences

Volumn 13, Issue SUPPL. 1, 2009, Pages 55-62

  Puglisi, M A ^a   Sgambato, A ^a   Saulnier, N ^a   Rafanelli, F ^a   Barba, M ^a   Boninsegna, A ^a   Piscaglia, A C ^a   Lauritano, C ^a   Novi, M L ^a   Barbaro, F ^a   Rinninella, E ^a   Campanale, C ^a   Giuliante, F ^a   Nuzzo, G ^a   Alfieri, S ^a   Doglietto, G B ^a   Cittadini, A ^a   Gasbarrini, A ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Cancer stem cells; CD133 cell population; Colon cancer; Liver metastatic colon cancer

Indexed keywords

CD133 ANTIBODY; CD133 ANTIGEN; CD31 ANTIBODY; CD45 ANTIBODY; CELL ANTIBODY; COLLAGENASE; UNCLASSIFIED DRUG; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; TUMOR MARKER;

ADULT; AGED; ARTICLE; CELL FRACTIONATION; CELL ISOLATION; CELL POPULATION; CELL SELECTION; CELL SUSPENSION; CLINICAL ARTICLE; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER METASTASIS; MALE; PRIMARY TUMOR; CANCER STEM CELL; COLON TUMOR; DRUG SCREENING; LIVER TUMOR; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY;

AGED; ANTIGENS, CD; COLONIC NEOPLASMS; FEMALE; FLOW CYTOMETRY; GLYCOPROTEINS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASTIC STEM CELLS; PEPTIDES; TUMOR MARKERS, BIOLOGICAL; TUMOR STEM CELL ASSAY;

EID: 65249182549     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. JEMAL A, SIEGEL R, WARD E, MURRAY T, XU J, SMIGAL C, THUN MJ. Cancer statistics, 2006. CA Cancer J Clin 2006; 56: 106-130.
2. RICCI-VITIANI L, PAGLIUCA A, PALIO E, ZEUNER A, DE MARIA R. Colon cancer stem cells. Gut 2008; 57: 538-548
3. REYA T, MORRISON SJ, CLARKE MF, WEISSMAN IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111
4. VERMEULEN L, SPRICK MR, KEMPER K, STASSI G, MEDEMA JP. Cancer stem cells - old concepts, new insights. Cell Death Differ 2008; 15: 947-958
5. PISCAGLIA AC, SHUPE TD, PETERSEN BE, GASBARRINI A. Stem cells, cancer, liver, and liver cancer stem cells: Finding a way out of the labyrinth. Curr Cancer Drug Targets 2007; 7: 582-590.
6. BONNET D, DICK JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-737.
7. RICCI-VITIANI L, LOMBARDI DG, PILOZZI E, BIFFONI M, TODARO M, PESCHLE C, DE MARIA R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007; 445: 111-115
8. O'BRIEN CA, POLLETT A, GALLINGER S, DICK JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007; 445: 106-110
9. LI F, TIEDE B, MASSAGUÉ J, KANG Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 2007; 17: 3-14.
10. YIN S, LI J, HU C, CHEN X, YAO M, YAN M, JIANG G, GE C, XIE H, WAN D, YANG S, ZHENG S, GU J. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer 2007; 120: 1444-1450.
11. SUETSUGU A, NAGAKI M, AOKI H, MOTOHASHI T, KUNISADA T, MORIWAKI H. Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem Biophys Res Commun 2006; 351: 820-824.
12. MIZRAK D, BRITTAN M, ALISON MR. CD133: Molecule of the moment. J Pathol 2008; 214: 3-9.
13. FEARON ER, VOGELSTEIN B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767.
14. HEPPNER GH. Tumor heterogeneity. Cancer Res 1984; 44: 2259-2265.
15. HILL RP. Identifying cancer stem cells in solid tumors: Case not proven. Cancer Res 2006; 66: 1891-1895.
16. WANG JC, DICK JE. Cancer stem cells: Lessons from leukemia. Trends Cell Biol 2005; 15: 494-501.
17. AL-HAJJ M, WICHA MS, BENITO-HERNANDEZ A, MORRISON SJ, CLARKE MF. Prospective identification of tumorigenic breast cancer cells.Proc Natl Acad Sci U S A 2003; 100: 3983-3988.
18. SINGH SK, HAWKINS C, CLARKE ID, SQUIRE JA, BAYANI J, HIDE T, HENKELMAN RM, CUSIMANO MD, DIRKS PB. Identification of human brain tumour initiating cells. Nature 2004; 430: 396-401.
19. GUAN Y, GERHARD B, HOGGE DE. Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). Blood 2003; 101: 3142-3149.
20. GUZMAN ML, SWIDERSKI CF, HOWARD DS, GRIMES BA, ROSSI RM, SZILVASSY SJ, JORDAN CT. Preferential induction of apoptosis for primary human leukemic stem cells. Proc Natl Acad Sci USA 2002; 99: 16220-16225.
21. DEAN M, FOJO T, BATES S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005; 5: 275-284.