Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 5, 2015, Pages 1186-1195.e6

  Lo, Chun Yu ^a,b,c   Michaeloudes, Charalambos ^a,b   Bhavsar, Pankaj K ^a,b   Huang, Chien Da ^c   Wang, Chun Hua ^c   Kuo, Han Pin ^c   Chung, Kian Fan ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

asthma; CCR7; corticosteroids; Fibrocytes; glucocorticoid receptor; myofibroblasts; nonadherent non T cells; PBMCs; remodeling

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BECLOMETASONE DIPROPIONATE; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR7; COLLAGEN TYPE 1; CORTICOSTEROID; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; PREDNISOLONE; ANTIASTHMATIC AGENT;

ADULT; APOPTOSIS; ARTICLE; ASTHMA; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SENSITIVITY; FEMALE; FIBROCYTE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MYOFIBROBLAST; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TREATMENT RESPONSE; CASE CONTROL STUDY; CELL COUNT; CONNECTIVE TISSUE CELL; CYTOLOGY; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; PHENOTYPE; SEVERITY OF ILLNESS INDEX;

ADRENAL CORTEX HORMONES; ADULT; ANTI-ASTHMATIC AGENTS; APOPTOSIS; ASTHMA; CASE-CONTROL STUDIES; CELL COUNT; CELL DIFFERENTIATION; CONNECTIVE TISSUE CELLS; DRUG RESISTANCE; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; RECEPTORS, CCR7; RECEPTORS, GLUCOCORTICOID; SEVERITY OF ILLNESS INDEX;

EID: 84937512230     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.10.031     Document Type: Article

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