Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Liu, Ji Yuan ^a   Chen, Xi En ^a   Zhang, Ya Lin ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CANTHARIDIN; ENZYME INHIBITOR; LIGAND; NUCLEAR PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN BINDING; PROTEIN PHOSPHATASE 5;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; DRUG DESIGN; GENETICS; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ALANINE; CANTHARIDIN; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937509324     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep12359     Document Type: Article

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