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Volumn 116, Issue 9, 2015, Pages 2109-2119

Acute Treatment with XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice

Author keywords

CHO CELLS; DIABETES; INSULIN ANALOG; INSULIN RECEPTOR; LIVER; PARTIAL ALLOSTERIC AGONIST

Indexed keywords

3 HYDROXYBUTYRIC ACID; FAT; FATTY ACID; GLYCEROL; HUMAN MONOCLONAL ANTIBODY; INSULIN RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY XMETA; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; INSULIN;

EID: 84937468623     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.25168     Document Type: Article
Times cited : (8)

References (40)
  • 1
    • 84923376166 scopus 로고    scopus 로고
    • Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody
    • Bedinger DH, Goldfine ID, Corbin JA, Roell MK, Adams SH,. 2015. Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody. J Pharmacol Exp Ther. 353 (1): 35-43.
    • (2015) J Pharmacol Exp Ther , vol.353 , Issue.1 , pp. 35-43
    • Bedinger, D.H.1    Goldfine, I.D.2    Corbin, J.A.3    Roell, M.K.4    Adams, S.H.5
  • 4
    • 3843142823 scopus 로고    scopus 로고
    • Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression
    • Bluher M, Patti ME, Gesta S, Kahn BB, Kahn CR,. 2004. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem 279: 31891-31901.
    • (2004) J Biol Chem , vol.279 , pp. 31891-31901
    • Bluher, M.1    Patti, M.E.2    Gesta, S.3    Kahn, B.B.4    Kahn, C.R.5
  • 5
    • 0018137212 scopus 로고
    • Mechanism of action of insulin in diabetic patients: A dose-related effect on glucose production and utilisation
    • Brown PM, Tompkins CV, Juul S, Sonksen PH,. 1978. Mechanism of action of insulin in diabetic patients: A dose-related effect on glucose production and utilisation. Br Med J 1: 1239-1242.
    • (1978) Br Med J , vol.1 , pp. 1239-1242
    • Brown, P.M.1    Tompkins, C.V.2    Juul, S.3    Sonksen, P.H.4
  • 6
    • 33750110683 scopus 로고    scopus 로고
    • Fuel metabolism in starvation
    • Cahill GF, Jr., 2006. Fuel metabolism in starvation. Annu Rev Nutr 26: 1-22.
    • (2006) Annu Rev Nutr , vol.26 , pp. 1-22
    • Cahill, Jr.G.F.1
  • 7
    • 0016806850 scopus 로고
    • Hepatic balances of glucose and insulin in response to physiological increments of endogenous insulin during glucose infusions in dogs
    • Camu F,. 1975. Hepatic balances of glucose and insulin in response to physiological increments of endogenous insulin during glucose infusions in dogs. Eur J Clin Invest 5: 101-108.
    • (1975) Eur J Clin Invest , vol.5 , pp. 101-108
    • Camu, F.1
  • 9
    • 0031851426 scopus 로고    scopus 로고
    • The direct and indirect effects of insulin on hepatic glucose production in vivo
    • Cherrington AD, Edgerton D, Sindelar DK,. 1998. The direct and indirect effects of insulin on hepatic glucose production in vivo. Diabetologia 41: 987-996.
    • (1998) Diabetologia , vol.41 , pp. 987-996
    • Cherrington, A.D.1    Edgerton, D.2    Sindelar, D.K.3
  • 10
    • 0027368014 scopus 로고
    • Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans
    • Fanelli C, Calderone S, Epifano L, De Vincenzo A, Modarelli F, Pampanelli S, Perriello G, De Feo P, Brunetti P, Gerich JE, et al., 1993. Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest 92: 1617-1622.
    • (1993) J Clin Invest , vol.92 , pp. 1617-1622
    • Fanelli, C.1    Calderone, S.2    Epifano, L.3    De Vincenzo, A.4    Modarelli, F.5    Pampanelli, S.6    Perriello, G.7    De Feo, P.8    Brunetti, P.9    Gerich, J.E.10
  • 11
    • 34748877223 scopus 로고    scopus 로고
    • Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice
    • Garg A, Balthasar JP,. 2007. Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice. J Pharmacokinet Pharmacodyn 34: 687-709.
    • (2007) J Pharmacokinet Pharmacodyn , vol.34 , pp. 687-709
    • Garg, A.1    Balthasar, J.P.2
  • 12
    • 0025273867 scopus 로고
    • The rat insulin receptor: Primary structure and conservation of tissue-specific alternative messenger RNA splicing
    • Goldstein BJ, Dudley AL,. 1990. The rat insulin receptor: Primary structure and conservation of tissue-specific alternative messenger RNA splicing. Mol Endocrinol 4: 235-244.
    • (1990) Mol Endocrinol , vol.4 , pp. 235-244
    • Goldstein, B.J.1    Dudley, A.L.2
  • 14
    • 8644234910 scopus 로고    scopus 로고
    • Antibody pharmacokinetics and pharmacodynamics
    • Lobo ED, Hansen RJ, Balthasar JP,. 2004. Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci 93: 2645-2668.
    • (2004) J Pharm Sci , vol.93 , pp. 2645-2668
    • Lobo, E.D.1    Hansen, R.J.2    Balthasar, J.P.3
  • 15
    • 84893041726 scopus 로고    scopus 로고
    • LY2605541-A preferential hepato-specific insulin analogue
    • Madsbad S,. 2014. LY2605541-A preferential hepato-specific insulin analogue. Diabetes 63: 390-392.
    • (2014) Diabetes , vol.63 , pp. 390-392
    • Madsbad, S.1
  • 16
    • 0026468362 scopus 로고
    • What if Minkowski had been ageusic? An alternative angle on diabetes
    • McGarry JD,. 1992. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258: 766-770.
    • (1992) Science , vol.258 , pp. 766-770
    • McGarry, J.D.1
  • 17
    • 0018864840 scopus 로고
    • Regulation of hepatic fatty acid oxidation and ketone body production
    • McGarry JD, Foster DW,. 1980. Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 49: 395-420.
    • (1980) Annu Rev Biochem , vol.49 , pp. 395-420
    • McGarry, J.D.1    Foster, D.W.2
  • 19
    • 0031467268 scopus 로고    scopus 로고
    • Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia
    • Mittelman SD, Fu YY, Rebrin K, Steil G, Bergman RN,. 1997. Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia. J Clin Invest 100: 3121-3130.
    • (1997) J Clin Invest , vol.100 , pp. 3121-3130
    • Mittelman, S.D.1    Fu, Y.Y.2    Rebrin, K.3    Steil, G.4    Bergman, R.N.5
  • 20
    • 0024403208 scopus 로고
    • Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man
    • Moller DE, Yokota A, Caro JF, Flier JS,. 1989. Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol Endocrinol 3: 1263-1269.
    • (1989) Mol Endocrinol , vol.3 , pp. 1263-1269
    • Moller, D.E.1    Yokota, A.2    Caro, J.F.3    Flier, J.S.4
  • 22
    • 0025362295 scopus 로고
    • Functionally distinct insulin receptors generated by tissue-specific alternative splicing
    • Mosthaf L, Grako K, Dull TJ, Coussens L, Ullrich A, McClain DA,. 1990. Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J 9: 2409-2413.
    • (1990) EMBO J , vol.9 , pp. 2409-2413
    • Mosthaf, L.1    Grako, K.2    Dull, T.J.3    Coussens, L.4    Ullrich, A.5    McClain, D.A.6
  • 24
    • 0013844340 scopus 로고
    • The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus
    • Randle PJ, Garland PB, Newsholme EA, Hales CN,. 1965. The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann N Y Acad Sci 131: 324-333.
    • (1965) Ann N y Acad Sci , vol.131 , pp. 324-333
    • Randle, P.J.1    Garland, P.B.2    Newsholme, E.A.3    Hales, C.N.4
  • 25
    • 17744405359 scopus 로고
    • Dose-response characteristics for effects of insulin on production and utilization of glucose in man
    • Rizza RA, Mandarino LJ, Gerich JE,. 1981. Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol 240: E630-639.
    • (1981) Am J Physiol , vol.240 , pp. E630-E639
    • Rizza, R.A.1    Mandarino, L.J.2    Gerich, J.E.3
  • 26
    • 14544269997 scopus 로고    scopus 로고
    • Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: Modulation by aging and differentiation in rat adipose tissue
    • Serrano R, Villar M, Martinez C, Carrascosa JM, Gallardo N, Andres A,. 2005. Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: Modulation by aging and differentiation in rat adipose tissue. J Mol Endocrinol 34: 153-161.
    • (2005) J Mol Endocrinol , vol.34 , pp. 153-161
    • Serrano, R.1    Villar, M.2    Martinez, C.3    Carrascosa, J.M.4    Gallardo, N.5    Andres, A.6
  • 29
    • 0029969117 scopus 로고    scopus 로고
    • A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog
    • Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD,. 1996. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45: 1594-1604.
    • (1996) Diabetes , vol.45 , pp. 1594-1604
    • Sindelar, D.K.1    Balcom, J.H.2    Chu, C.A.3    Neal, D.W.4    Cherrington, A.D.5
  • 31
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD,. 2005. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85: 1093-1129.
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 32
    • 0031897505 scopus 로고    scopus 로고
    • Role of portal insulin delivery in the disappearance of intravenous glucose and assessment of insulin sensitivity
    • Steil GM, Rebrin K, Mittelman SD, Bergman RN,. 1998. Role of portal insulin delivery in the disappearance of intravenous glucose and assessment of insulin sensitivity. Diabetes 47: 714-720.
    • (1998) Diabetes , vol.47 , pp. 714-720
    • Steil, G.M.1    Rebrin, K.2    Mittelman, S.D.3    Bergman, R.N.4
  • 33
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR,. 2006. Critical nodes in signalling pathways: Insights into insulin action. Nat Rev Mol Cell Biol 7: 85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 34
    • 84855459920 scopus 로고    scopus 로고
    • Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
    • Unger RH, Cherrington AD,. 2012. Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover. J Clin Invest 122: 4-12.
    • (2012) J Clin Invest , vol.122 , pp. 4-12
    • Unger, R.H.1    Cherrington, A.D.2
  • 35
    • 83655165302 scopus 로고    scopus 로고
    • Receptor antibodies as novel therapeutics for diabetes
    • 113ps47.
    • Ussar S, Vienberg SG, Kahn CR,. 2011. Receptor antibodies as novel therapeutics for diabetes. Sci Transl Med 3:113ps47.
    • (2011) Sci Transl Med , vol.3
    • Ussar, S.1    Vienberg, S.G.2    Kahn, C.R.3
  • 36
    • 74049096713 scopus 로고    scopus 로고
    • Biodistribution of [125I]-labeled therapeutic proteins: Application in protein drug development beyond oncology
    • Vugmeyster Y, DeFranco D, Szklut P, Wang Q, Xu X,. 2010. Biodistribution of [125I]-labeled therapeutic proteins: Application in protein drug development beyond oncology. J Pharm Sci 99: 1028-1045.
    • (2010) J Pharm Sci , vol.99 , pp. 1028-1045
    • Vugmeyster, Y.1    DeFranco, D.2    Szklut, P.3    Wang, Q.4    Xu, X.5
  • 37
    • 54249138516 scopus 로고    scopus 로고
    • Monoclonal antibody pharmacokinetics and pharmacodynamics
    • Wang W, Wang EQ, Balthasar JP,. 2008. Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther 84: 548-558.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 548-558
    • Wang, W.1    Wang, E.Q.2    Balthasar, J.P.3
  • 38
    • 0025941580 scopus 로고
    • Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells
    • Yamaguchi Y, Flier JS, Yokota A, Benecke H, Backer JM, Moller DE,. 1991. Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells. Endocrinology 129: 2058-2066.
    • (1991) Endocrinology , vol.129 , pp. 2058-2066
    • Yamaguchi, Y.1    Flier, J.S.2    Yokota, A.3    Benecke, H.4    Backer, J.M.5    Moller, D.E.6
  • 40
    • 0030020697 scopus 로고    scopus 로고
    • Role of insulin in hepatic fatty acid partitioning: Emerging concepts
    • Zammit VA,. 1996. Role of insulin in hepatic fatty acid partitioning: Emerging concepts. Biochem J 314 (Pt 1): 1-14.
    • (1996) Biochem J , vol.314 , pp. 1-14
    • Zammit, V.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.