-
1
-
-
83655165300
-
Amelioration of type 2 diabetes by antibody-mediated activation of fi broblast growth factor receptor 1
-
A.-L. Wu, G. Kolumam, S. Stawicki, Y. Chen, J. Li, J. Zavala- Solorio, K. Phamluong, B. Feng, L. Li, S. Marsters, L. Kates, N. van Bruggen, M. Leabman, A. Wong, D. West, H. Stern, E. Luis, H. Seon Kim, D. Yansura, A. S. Peterson, E. Filvaroff, Y. Wu, J. Sonoda, Amelioration of type 2 diabetes by antibody-mediated activation of fi broblast growth factor receptor 1. Sci. Transl. Med. 3, 113ra126 (2011).
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Wu, A.-L.1
Kolumam, G.2
Stawicki, S.3
Chen, Y.4
Li, J.5
Zavala- Solorio, J.6
Phamluong, K.7
Feng, B.8
Li, L.9
Marsters, S.10
Kates, L.11
Van Bruggen, N.12
Leabman, M.13
Wong, A.14
West, D.15
Stern, H.16
Luis, E.17
Seon Kim, H.18
Yansura, D.19
Peterson, A.S.20
Filvaroff, E.21
Wu, Y.22
Sonoda, J.23
more..
-
2
-
-
70350572832
-
TSH receptor autoantibodies
-
K. Michalek, S. A. Morshed, R. Latif, T. F. Davies, TSH receptor autoantibodies. Autoimmun. Rev. 9, 113-116 (2009).
-
(2009)
Autoimmun. Rev.
, vol.9
, pp. 113-116
-
-
Michalek, K.1
Morshed, S.A.2
Latif, R.3
Davies, T.F.4
-
3
-
-
0018414048
-
Receptors, antireceptor antibodies and mechanisms of insulin resistance
-
J. S. Flier, C. R. Kahn, J. Roth, Receptors, antireceptor antibodies and mechanisms of insulin resistance. N. Engl. J. Med. 300, 413-419 (1979).
-
(1979)
N. Engl. J. Med.
, vol.300
, pp. 413-419
-
-
Flier, J.S.1
Kahn, C.R.2
Roth, J.3
-
4
-
-
65749120107
-
Autoimmune disorders of the neuromuscular junction
-
B. Lang, A. Vincent, Autoimmune disorders of the neuromuscular junction. Curr. Opin. Pharmacol. 9, 336-340 (2009).
-
(2009)
Curr. Opin. Pharmacol.
, vol.9
, pp. 336-340
-
-
Lang, B.1
Vincent, A.2
-
5
-
-
74049108945
-
Fibroblast growth factor 21: From pharmacology to physiology
-
S. A. Kliewer, D. J. Mangelsdorf, Fibroblast growth factor 21: From pharmacology to physiology. Am. J. Clin. Nutr. 91, 254S-257S (2010).
-
(2010)
Am. J. Clin. Nutr.
, vol.91
-
-
Kliewer, S.A.1
Mangelsdorf, D.J.2
-
6
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
A. Kharitonenkov, T. L. Shiyanova, A. Koester, A. M. Ford, R. Micanovic, E. J. Galbreath, G. E. Sandusky, L. J. Hammond, J. S. Moyers, R. A. Owens, J. Gromada, J. T. Brozinick, E. D. Hawkins, V. J. Wroblewski, D. S. Li, F. Mehrbod, S. R. Jaskunas, A. B. Shanafelt, FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115, 1627-1635 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1627-1635
-
-
Kharitonenkov, A.1
Shiyanova, T.L.2
Koester, A.3
Ford, A.M.4
Micanovic, R.5
Galbreath, E.J.6
Sandusky, G.E.7
Hammond, L.J.8
Moyers, J.S.9
Owens, R.A.10
Gromada, J.11
Brozinick, J.T.12
Hawkins, E.D.13
Wroblewski, V.J.14
Li, D.S.15
Mehrbod, F.16
Jaskunas, S.R.17
Shanafelt, A.B.18
-
7
-
-
34848869695
-
Tissue-specifi c expression of betaKlotho and fi broblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
-
H. Kurosu, M. Choi, Y. Ogawa, A. S. Dickson, R. Goetz, A. V. Eliseenkova, M. Mohammadi, K. P. Rosenblatt, S. A. Kliewer, M. Kuro-o, Tissue-specifi c expression of betaKlotho and fi broblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J. Biol. Chem. 282, 26687-26695 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26687-26695
-
-
Kurosu, H.1
Choi, M.2
Ogawa, Y.3
Dickson, A.S.4
Goetz, R.5
Eliseenkova, A.V.6
Mohammadi, M.7
Rosenblatt, K.P.8
Kliewer, S.A.9
Kuro-o, M.10
-
8
-
-
0031946518
-
Short communication: Renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins
-
A. Bendele, J. Seely, C. Richey, G. Sennello, G. Shopp, Short communication: Renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins. Toxicol. Sci. 42, 152-157 (1998).
-
(1998)
Toxicol. Sci.
, vol.42
, pp. 152-157
-
-
Bendele, A.1
Seely, J.2
Richey, C.3
Sennello, G.4
Shopp, G.5
-
9
-
-
78049297991
-
Obesity is a fi broblast growth factor 21 (FGF21)-resistant state
-
F. M. Fisher, P. C. Chui, P. J. Antonellis, H. A. Bina, A. Kharitonenkov, J. S. Flier, E. Maratos-Flier, Obesity is a fi broblast growth factor 21 (FGF21)-resistant state. Diabetes 59, 2781-2789 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 2781-2789
-
-
Fisher, F.M.1
Chui, P.C.2
Antonellis, P.J.3
Bina, H.A.4
Kharitonenkov, A.5
Flier, J.S.6
Maratos-Flier, E.7
-
10
-
-
79959713140
-
Fibroblast growth factors and their receptors in cancer
-
J. Wesche, K. Haglund, E. M. Haugsten, Fibroblast growth factors and their receptors in cancer. Biochem. J. 437, 199-213 (2011).
-
(2011)
Biochem. J.
, vol.437
, pp. 199-213
-
-
Wesche, J.1
Haglund, K.2
Haugsten, E.M.3
-
11
-
-
77954277205
-
Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
-
D. A. Sarruf, J. P. Thaler, G. J. Morton, J. German, J. D. Fischer, K. Ogimoto, M. W. Schwartz, Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes 59, 1817-1824 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 1817-1824
-
-
Sarruf, D.A.1
Thaler, J.P.2
Morton, G.J.3
German, J.4
Fischer, J.D.5
Ogimoto, K.6
Schwartz, M.W.7
-
12
-
-
50049127055
-
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
-
Y. H. Tseng, E. Kokkotou, T. J. Schulz, T. L. Huang, J. N. Winnay, C. M. Taniguchi, T. T. Tran, R. Suzuki, D. O. Espinoza, Y. Yamamoto, M. J. Ahrens, A. T. Dudley, A. W. Norris, R. N. Kulkarni, C. R. Kahn, New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454, 1000-1004 (2008).
-
(2008)
Nature
, vol.454
, pp. 1000-1004
-
-
Tseng, Y.H.1
Kokkotou, E.2
Schulz, T.J.3
Huang, T.L.4
Winnay, J.N.5
Taniguchi, C.M.6
Tran, T.T.7
Suzuki, R.8
Espinoza, D.O.9
Yamamoto, Y.10
Ahrens, M.J.11
Dudley, A.T.12
Norris, A.W.13
Kulkarni, R.N.14
Kahn, C.R.15
-
13
-
-
0027333427
-
Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level
-
P. R. Srinivas, A. S. Wagner, L. V. Reddy, D. D. Deutsch, M. A. Leon, A. S. Goustin, G. Grunberger, Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol. Endocrinol. 7, 1445-1455 (1993).
-
(1993)
Mol. Endocrinol.
, vol.7
, pp. 1445-1455
-
-
Srinivas, P.R.1
Wagner, A.S.2
Reddy, L.V.3
Deutsch, D.D.4
Leon, M.A.5
Goustin, A.S.6
Grunberger, G.7
-
14
-
-
33646078811
-
Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia
-
B. A. Maddux, Y. N. Chang, D. Accili, O. P. McGuinness, J. F. Youngren, I. D. Goldfi ne, Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia. Am. J. Physiol. Endocrinol. Metab. 290, E746-E749 (2006).
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.290
-
-
Maddux, B.A.1
Chang, Y.N.2
Accili, D.3
McGuinness, O.P.4
Youngren, J.F.5
Goldfine, I.D.6
-
15
-
-
79956023778
-
Physiological inhibitors of Wnt signaling
-
A. Filipovich, I. Gehrke, S. J. Poll-Wolbeck, K. A. Kreuzer, Physiological inhibitors of Wnt signaling. Eur. J. Haematol. 86, 453-465 (2011).
-
(2011)
Eur. J. Haematol.
, vol.86
, pp. 453-465
-
-
Filipovich, A.1
Gehrke, I.2
Poll-Wolbeck, S.J.3
Kreuzer, K.A.4
-
16
-
-
6044239186
-
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis
-
E. A. Partridge, C. Le Roy, G. M. Di Guglielmo, J. Pawling, P. Cheung, M. Granovsky, I. R. Nabi, J. L. Wrana, J. W. Dennis, Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306, 120-124 (2004).
-
(2004)
Science
, vol.306
, pp. 120-124
-
-
Partridge, E.A.1
Le Roy, C.2
Di Guglielmo, G.M.3
Pawling, J.4
Cheung, P.5
Granovsky, M.6
Nabi, I.R.7
Wrana, J.L.8
Dennis, J.W.9
-
17
-
-
83655189243
-
High affi nity insulin receptor antibodies sensitize the insulin receptor to insulin and restore glycemic control in murine models of diabetes
-
J. A. Corbin, V. Bhaskar, I. D. Goldfi ne, D. H. Bedinger, H. F. Kuan, L. Gross, A. Lau, M. Handa, S. R. Watson, L. Webster, R. Levy, B. A. Maddux, S. Wijesuriya, N. Liu, X. Wu, D. Chemla-Vogel, A. J. Narasimha, S. R. Lee, C. Tran, M. L. White, High affi nity insulin receptor antibodies sensitize the insulin receptor to insulin and restore glycemic control in murine models of diabetes. Diabetes 60, A276 (2011).
-
(2011)
Diabetes
, vol.60
-
-
Corbin, J.A.1
Bhaskar, V.2
Goldfi Ne, I.D.3
Bedinger, D.H.4
Kuan, H.F.5
Gross, L.6
Lau, A.7
Handa, M.8
Watson, S.R.9
Webster, L.10
Levy, R.11
Maddux, B.A.12
Wijesuriya, S.13
Liu, N.14
Wu, X.15
Chemla-Vogel, D.16
Narasimha, A.J.17
Lee, S.R.18
Tran, C.19
White, M.L.20
more..
-
18
-
-
73349089955
-
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia
-
W. Gu, H. Yan, K. A. Winters, R. Komorowski, S. Vonderfecht, L. Atangan, G. Sivits, D. Hill, J. Yang, V. Bi, Y. Shen, S. Hu, T. Boone, R. A. Lindberg, M. M. Véniant, Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia. J. Pharmacol. Exp. Ther. 331, 871-881 (2009).
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.331
, pp. 871-881
-
-
Gu, W.1
Yan, H.2
Winters, K.A.3
Komorowski, R.4
Vonderfecht, S.5
Atangan, L.6
Sivits, G.7
Hill, D.8
Yang, J.9
Bi, V.10
Shen, Y.11
Hu, S.12
Boone, T.13
Lindberg, R.A.14
Véniant, M.M.15
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