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Volumn 23, Issue 13, 2015, Pages 3260-3268
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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
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Author keywords
BACE inhibitor; Complex organic synthesis; Conformational constraint; Stereoselective; Structure based drug design
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Indexed keywords
ENZYME INHIBITOR;
N [ 10 AMINO 4,4A,5,6,7,8 HEXAHYDRO 1H,3H 4,8A (EPITHIOMETHENOAZENO)ISOCHROMEN 6 YL] 3 CHLOROBENZAMIDE;
N [2 AMINO 5,6,7,8 TETRAHYDRO 4H 4A,8A (METHANOOXYMETHANO)BENZO[D][1,3]THIAZIN 6 YL] 3 CHLOROBENZAMIDE;
UNCLASSIFIED DRUG;
ASPARTIC PROTEINASE;
BACE1 PROTEIN, HUMAN;
BICYCLO COMPOUND;
PROTEINASE INHIBITOR;
SECRETASE;
THIAZINE DERIVATIVE;
ARTICLE;
COMPLEX FORMATION;
CONTROLLED STUDY;
DRUG CONFORMATION;
DRUG DESIGN;
DRUG DETERMINATION;
DRUG STRUCTURE;
DRUG TARGETING;
IC50;
IN VITRO STUDY;
IN VIVO STUDY;
PHYSICAL CHEMISTRY;
STEREOCHEMISTRY;
STRUCTURE ACTIVITY RELATION;
ANIMAL;
ANTAGONISTS AND INHIBITORS;
BRAIN CHEMISTRY;
CHEMISTRY;
CONFORMATION;
HUMAN;
ISOLATION AND PURIFICATION;
MOLECULAR DOCKING;
MOUSE;
STEREOISOMERISM;
SYNTHESIS;
X RAY CRYSTALLOGRAPHY;
AMYLOID PRECURSOR PROTEIN SECRETASES;
ANIMALS;
ASPARTIC ACID ENDOPEPTIDASES;
BICYCLO COMPOUNDS;
BRAIN CHEMISTRY;
CRYSTALLOGRAPHY, X-RAY;
DRUG DESIGN;
HUMANS;
MICE;
MOLECULAR CONFORMATION;
MOLECULAR DOCKING SIMULATION;
PROTEASE INHIBITORS;
STEREOISOMERISM;
THIAZINES;
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EID: 84937435587
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2015.04.062 Document Type: Article |
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Times cited : (16)
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References (21)
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