Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent

Journal of Medicinal Chemistry

Volumn 48, Issue 22, 2005, Pages 7055-7062

  Corea, Gabriella ^a   Fattorusso, Ernesto ^a   Lanzotti, Virginia ^b   Di Meglio, Paola ^a   Maffia, Pasquale ^a   Grassia, Gianluca ^a   Ialenti, Armando ^a   Ianaro, Angela ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MOLISE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTIINFLAMMATORY AGENT; CARRAGEENAN; CYCLOOXYGENASE 2; DEXAMETHASONE; DITERPENE; EUPHORBIA EXTRACT; HEXANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; PEPLUANONE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CONTROLLED STUDY; DOWN REGULATION; DRUG ISOLATION; DRUG STRUCTURE; EUPHORBIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; DITERPENES; EDEMA; EUPHORBIA; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 27444435484     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050321r     Document Type: Article

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