메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages 1423-1429

Mutation of the PIK3CA gene as a prognostic factor in patients with colorectal cancer

Author keywords

Colorectal cancer; Phosphatidylinositol 4,5 bisphosphate 3 kinase catalytic subunit alpha mutations; Prognostic factor

Indexed keywords

B RAF KINASE; K RAS PROTEIN;

EID: 84937404786     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.3398     Document Type: Article
Times cited : (10)

References (31)
  • 2
    • 76049098292 scopus 로고    scopus 로고
    • Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases
    • Baldus SE, Schaefer KL, Engers R, Hartleb D, Stoecklein NH and Gabbert HE: Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res16: 790-799, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 790-799
    • Baldus, S.E.1    Schaefer, K.L.2    Engers, R.3    Hartleb, D.4    Stoecklein, N.H.5    Gabbert, H.E.6
  • 3
    • 84870812342 scopus 로고    scopus 로고
    • Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: Beyond KRAS mutations
    • Custodio A and Feliu J: Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: Beyond KRAS mutations. Crit Rev Oncol Hematol85: 45-81, 2013.
    • (2013) Crit Rev Oncol Hematol , vol.85 , pp. 45-81
    • Custodio, A.1    Feliu, J.2
  • 4
    • 84881543270 scopus 로고    scopus 로고
    • Promising biomarkers for predicting the outcomes of patients with KRAS wild-type metastatic colorectal cancer treated with anti-epidermal growth factor receptor monoclonal antibodies: A systematic review with meta-analysis
    • Yang ZY, Wu XY, Huang YF, Di MY, Zheng DY, Chen JZ, DingH, Mao C and Tang JL: Promising biomarkers for predicting the outcomes of patients with KRAS wild-type metastatic colorectal cancer treated with anti-epidermal growth factor receptor monoclonal antibodies: A systematic review with meta-analysis. Int J Cancer133: 1914-1925, 2013.
    • (2013) Int J Cancer , vol.133 , pp. 1914-1925
    • Yang, Z.Y.1    Wu, X.Y.2    Huang, Y.F.3    Di, M.Y.4    Zheng, D.Y.5    Chen, J.Z.6    Ding, H.7    Mao, C.8    Tang, J.L.9
  • 5
    • 84882648383 scopus 로고    scopus 로고
    • Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan-and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer
    • Soeda H, Shimodaira H, Watanabe M, Suzuki T, Gamoh M, MoriT, Komine K, Iwama N, Kato S and Ishioka C: Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan-and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer. Int J Clin Oncol18: 670-677, 2013.
    • (2013) Int J Clin Oncol , vol.18 , pp. 670-677
    • Soeda, H.1    Shimodaira, H.2    Watanabe, M.3    Suzuki, T.4    Gamoh, M.5    Mori, T.6    Komine, K.7    Iwama, N.8    Kato, S.9    Ishioka, C.10
  • 7
    • 84901573827 scopus 로고    scopus 로고
    • Mutations of KRAS and PIK3CA as independent predictors of distant metastases in colorectal cancer
    • Zhu K, Yan H, Wang R, Zhu H, Meng X, Xu X, Dou X and ChenD: Mutations of KRAS and PIK3CA as independent predictors of distant metastases in colorectal cancer. Med Oncol31: 16, 2014.
    • (2014) Med Oncol , vol.31 , pp. 16
    • Zhu, K.1    Yan, H.2    Wang, R.3    Zhu, H.4    Meng, X.5    Xu, X.6    Dou, X.7    Chen, D.8
  • 8
    • 84890480939 scopus 로고    scopus 로고
    • A small cog in a big wheel: PIK3CA mutations in colorectal cancer
    • Stintzing S and Lenz HJ: A small cog in a big wheel: PIK3CA mutations in colorectal cancer. JNatl Cancer Inst105: 1775-1776, 2013.
    • (2013) JNatl Cancer Inst , vol.105 , pp. 1775-1776
    • Stintzing, S.1    Lenz, H.J.2
  • 9
    • 21144457217 scopus 로고    scopus 로고
    • Functional analysis of PIK3CA gene mutations in human colorectal cancer
    • Ikenoue T, Kanai F, Hikiba Y, etal: Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res65: 4562-4567, 2005.
    • (2005) Cancer Res , vol.65 , pp. 4562-4567
    • Ikenoue, T.1    Kanai, F.2    Hikiba, Y.3
  • 10
    • 84879001702 scopus 로고    scopus 로고
    • PIK3CA activating mutation in colorectal carcinoma: Associations with molecular features and survival
    • Rosty C, Young JP, Walsh MD, etal: PIK3CA activating mutation in colorectal carcinoma: Associations with molecular features and survival. PLoS ONE8: e65479, 2013.
    • (2013) PLoS ONE , vol.8
    • Rosty, C.1    Young, J.P.2    Walsh, M.D.3
  • 11
    • 84892425103 scopus 로고    scopus 로고
    • Effectors of epidermal growth factor receptor pathway: The genetic profiling of KRAS, BRAF, PIK3CA, NRAS mutations in colorectal cancer characteristics and personalized medicine
    • Shen Y, Wang J, Han X, Yang H, Wang S, Lin D and Shi Y: Effectors of epidermal growth factor receptor pathway: The genetic profiling of KRAS, BRAF, PIK3CA, NRAS mutations in colorectal cancer characteristics and personalized medicine. PLoS ONE8: 12, 2013.
    • (2013) PLoS ONE , vol.8 , pp. 12
    • Shen, Y.1    Wang, J.2    Han, X.3    Yang, H.4    Wang, S.5    Lin, D.6    Shi, Y.7
  • 12
    • 84927561017 scopus 로고    scopus 로고
    • KRAS mutation in patients with metastatic colorectal cancer does not preclude benefit from oxaliplatin-or irinotecan-based treatment
    • Soeda H, Shimodaira H, Watanabe M, Suzuki T, Gamo M, Takahashi M, Komine K, Kato S and Ishioka C: KRAS mutation in patients with metastatic colorectal cancer does not preclude benefit from oxaliplatin-or irinotecan-based treatment. Mol Clin Oncol2: 356-362, 2014.
    • (2014) Mol Clin Oncol , vol.2 , pp. 356-362
    • Soeda, H.1    Shimodaira, H.2    Watanabe, M.3    Suzuki, T.4    Gamo, M.5    Takahashi, M.6    Komine, K.7    Kato, S.8    Ishioka, C.9
  • 13
    • 84900569919 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody-based therapy for metastatic colorectal cancer: A meta-analysis of the effect of PIK3CA mutations in KRAS wild-type patients
    • Huang L, Liu Z, Deng D, Tan A, Liao M, Mo Z and YangX: Anti-epidermal growth factor receptor monoclonal antibody-based therapy for metastatic colorectal cancer: A meta-analysis of the effect of PIK3CA mutations in KRAS wild-type patients. Arch Med Sci10: 1-9, 2014.
    • (2014) Arch Med Sci , vol.10 , pp. 1-9
    • Huang, L.1    Liu, Z.2    Deng, D.3    Tan, A.4    Liao, M.5    Mo, Z.6    Yang, X.7
  • 14
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer EA, Therasse P, Bogaerts J, etal: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer45: 228-247, 2009.
    • (2009) Eur J Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 15
    • 84868340002 scopus 로고    scopus 로고
    • K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan-or oxaliplatin-based chemotherapy
    • Stec R, Bodnar L, Charkiewicz R, etal: K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan-or oxaliplatin-based chemotherapy. Cancer Biol Ther13: 1235-1243, 2012.
    • (2012) Cancer Biol Ther , vol.13 , pp. 1235-1243
    • Stec, R.1    Bodnar, L.2    Charkiewicz, R.3
  • 16
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y, Wang Z, Bardelli A, etal: High frequency of mutations of the PIK3CA gene in human cancers. Science304: 554, 2004.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 18
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, etal: Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis. Lancet Oncol11: 753-762, 2010.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 19
    • 84901633656 scopus 로고    scopus 로고
    • EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab
    • Razis E, Pentheroudakis G, Rigakos G, etal: EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. JCancer Res Clin Oncol140: 737-748, 2014.
    • (2014) JCancer Res Clin Oncol , vol.140 , pp. 737-748
    • Razis, E.1    Pentheroudakis, G.2    Rigakos, G.3
  • 20
    • 84893641102 scopus 로고    scopus 로고
    • Personalized medicine in metastatic colorectal cancer treated with anti-epidermal growth factor receptor agents: A future opportunity?
    • Tejpar S and Piessevaux H: Personalized medicine in metastatic colorectal cancer treated with anti-epidermal growth factor receptor agents: A future opportunity? Asia Pac J Clin Oncol10: 2-10, 2014.
    • (2014) Asia Pac J Clin Oncol , vol.10 , pp. 2-10
    • Tejpar, S.1    Piessevaux, H.2
  • 21
    • 84869816018 scopus 로고    scopus 로고
    • KRAS mutation testing in colorectal cancer as an example of the pathologist's role in personalized targeted therapy: A practical approach
    • Domagała P, Hybiak J, Sulżyc-Bielicka V, Cybulski C, Ryś J and Domagała W: KRAS mutation testing in colorectal cancer as an example of the pathologist's role in personalized targeted therapy: A practical approach. Pol J Pathol63: 145-164, 2012.
    • (2012) Pol J Pathol , vol.63 , pp. 145-164
    • Domagała, P.1    Hybiak, J.2    Sulżyc-Bielicka, V.3    Cybulski, C.4    Ryś, J.5    Domagała, W.6
  • 22
    • 63049111794 scopus 로고    scopus 로고
    • PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    • Ogino S, Nosho K, Kirkner GJ, etal: PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. JClin Oncol27: 1477-1484, 2009.
    • (2009) JClin Oncol , vol.27 , pp. 1477-1484
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 24
    • 84901036853 scopus 로고    scopus 로고
    • PIK3CA in Colorectal Cancer
    • CathomasG: PIK3CA in Colorectal Cancer. Front Oncol4: 35, 2014.
    • (2014) Front Oncol , vol.4 , pp. 35
    • Cathomas, G.1
  • 25
    • 84873027952 scopus 로고    scopus 로고
    • Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes
    • Pentheroudakis G, Kotoula V, De Roock W, etal: Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC Cancer13: 49, 2013.
    • (2013) BMC Cancer , vol.13 , pp. 49
    • Pentheroudakis, G.1    Kotoula, V.2    De Roock, W.3
  • 26
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • Sartore-Bianchi A, Martini M, Molinari F, etal: PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res69: 1851-1857, 2009.
    • (2009) Cancer Res , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3
  • 27
    • 65649086786 scopus 로고    scopus 로고
    • PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
    • Prenen H, De Schutter J, Jacobs B, De Roock W, BiesmansB, Claes B, Lambrechts D, Van Cutsem E and Tejpar S: PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. Clin Cancer Res15: 3184-3188, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 3184-3188
    • Prenen, H.1    De Schutter, J.2    Jacobs, B.3    De Roock, W.4    Biesmans, B.5    Claes, B.6    Lambrechts, D.7    Van Cutsem, E.8    Tejpar, S.9
  • 28
    • 84903301924 scopus 로고    scopus 로고
    • The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis
    • Therkildsen C, Bergmann TK, Henrichsen-Schnack T, LadelundS and Nilbert M: The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis. Acta Oncol53: 852-864, 2014.
    • (2014) Acta Oncol , vol.53 , pp. 852-864
    • Therkildsen, C.1    Bergmann, T.K.2    Henrichsen-Schnack, T.3    Ladelund, S.4    Nilbert, M.5
  • 29
    • 84893461612 scopus 로고    scopus 로고
    • PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17
    • Karapetis CS, Jonker D, Daneshmand M, etal; NCIC Clinical Trials Group and the Australasian Gastro-Intestinal Trials Group: PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17. Clin Cancer Res20: 744-753, 2014.
    • (2014) Clin Cancer Res , vol.20 , pp. 744-753
    • Karapetis, C.S.1    Jonker, D.2    Daneshmand, M.3
  • 30
    • 84890448787 scopus 로고    scopus 로고
    • Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial
    • Ogino S, Liao X, Imamura Y, etal; Alliance for Clinical Trials in Oncology: Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial. JNatl Cancer Inst105: 1789-1798, 2013.
    • (2013) JNatl Cancer Inst , vol.105 , pp. 1789-1798
    • Ogino, S.1    Liao, X.2    Imamura, Y.3
  • 31
    • 84859865072 scopus 로고    scopus 로고
    • Prognostic role of PIK3CA mutation in colorectal cancer: Cohort study and literature review
    • Liao X, Morikawa T, Lochhead P, etal: Prognostic role of PIK3CA mutation in colorectal cancer: Cohort study and literature review. Clin Cancer Res18: 2257-2268, 2012.
    • (2012) Clin Cancer Res , vol.18 , pp. 2257-2268
    • Liao, X.1    Morikawa, T.2    Lochhead, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.