Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts

FASEB Journal

Volumn 29, Issue 3, 2015, Pages 1069-1079

  Zhang, Baohua ^a,b   Denomme, Michelle M ^c,d   White, Carlee R ^c,d   Leung, Kit Yi ^e   Lee, Martin B ^a,b   Greene, Nicholas D E ^e   Mann, Mellissa R W ^c,d   Trasler, Jacquetta M ^f,g   Baltz, Jay M ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c WESTERN UNIVERSITY   (Canada)

^d CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^g MCGILL UNIVERSITY   (Canada)

Author keywords

Embryo; Epigenetics; Inner cell mass; Methionine; S adenosylmethionine

Indexed keywords

5 METHYLCYTOSINE; 5 METHYLTETRAHYDROFOLIC ACID; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; FOLIC ACID; METHIONINE; METHOTREXATE; METHYL GROUP; MORPHOLINO OLIGONUCLEOTIDE; TETRAHYDROFOLIC ACID; ANTINEOPLASTIC ANTIMETABOLITE; S ADENOSYLMETHIONINE; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ANIMAL CELL; ARTICLE; BLASTOCYST; CELL COUNT; CELL COUNTING; CELL LINEAGE; COMPARATIVE STUDY; CONTROLLED STUDY; CROWN RUMP LENGTH; DNA METHYLATION; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; FETUS WEIGHT; FOLATE METABOLISM; IMMUNOFLUORESCENCE; INNER CELL MASS; MOUSE; NIDATION; NONHUMAN; PLACENTA WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNTHESIS; ANIMAL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; LIVER; METABOLISM;

5-METHYLCYTOSINE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; BLASTOCYST; CELL LINEAGE; CELLS, CULTURED; DNA METHYLATION; EMBRYO, MAMMALIAN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FOLIC ACID; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; METHOTREXATE; MICE; S-ADENOSYLMETHIONINE; SNRNP CORE PROTEINS;

EID: 84937397985     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-261131     Document Type: Article

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