High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes blaOXA-23-like, blaOXA-24-like and blaNDM-1 in Algiers hospitals

Asian Pacific Journal of Tropical Medicine

Volumn 8, Issue 6, 2015, Pages 438-446

  Khorsi, Khadidja ^a   Messai, Yamina ^a   Hamidi, Moufida ^b   Ammari, Houria ^c   Bakour, Rabah ^a  

^a UNIVERSITY OF SCIENCES AND TECHNOLOGY HOUARI BOUMEDIENE   (Algeria)

^b Department of Neurosurgery   (Algeria)

^c Department of Hematology Isaad Hassani Hospital   (Algeria)

Author keywords

Acinetobacter baumannii; Algiers; Carbapenemase; CarO; Hospital; Multidrug resistance

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; OFLOXACIN; OUTER MEMBRANE PROTEIN; PEFLOXACIN; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; TETRACYCLINE DERIVATIVE; TICARCILLIN;

AAC(6') IB GENE; ACINETOBACTER BAUMANNII; AGAR DILUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLANDM 1 GENE; BLAOXA 23 LIKE GENE; BLAOXA 24 LIKE GENE; CARO GENE; CONTROLLED STUDY; ENTEROBACTERIAL REPETITIVE INTERGENIC CONSENSUS POLYMERASE CHAIN REACTION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; INTEGRON; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; SUL1 GENE; SUL2 GENE; TETA GENE; TETB GENE;

EID: 84937253860     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apjtm.2015.05.011     Document Type: Article

References (55)

1. Bonnin R.A., Nordmann P., Poirel L. Screening and deciphering antibiotic resistance in Acinetobacter baumannii: a state of the art. Expert Rev Anti Infect Ther 2013, 11(6):571-583.
2. Gootz T.D., Marra A. Acinetobacter baumannii: an emerging multidrug-resistant threat. Expert Rev Anti Infect Ther 2008, 6(3):309-325.
3. Héritier C., Poirel L., Nordmann P. Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii. Clin Microbiol Infect 2006, 12(2):123-130.
4. Peleg A.Y., Seifert H., Paterson D.L. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev 2008, 21(3):538-582.
5. Poirel L., Naas T., Nordmann P. Diversity, epidemiology, and genetics of class D beta-lactamases. Antimicrobial Agents Chemother 2010, 54(1):24-38.
6. Dortet L., Poirel L., Nordmann P. Worldwide dissemination of the NDM-type carbapenemases in gram-negative bacteria. Biomed Res Int 2014, 2014:249856.
7. Mussi M.A., Limansky A.S., Viale A.M. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins. Antimicrobial Agents Chemother 2005, 49(4):1432-1440.
8. OXA-51-like carbapenemase gene intrinsic to this species. JClin Microbiol 2006, 44(8):2974-2976.
9. Antibiogramm Committee of French Society for Microbiology (CA-SFM). Communiqué 2013. [Online] Available at: . http://www.sfm-microbiologie.org.
10. Lee K., Chong Y., Shin H.B., Kim Y.A., Yong D., Yum J.H. Modified Hodge test and EDTA-disk synergy tests to screen metallo-β-lactamase-producing strains of Pseudomonas and Acinetobacter species. Clin Microbiol Infect 2001, 7(2):88-91.
11. Jarlier V., Nicolas M., Fournier G., Philippon A. Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns. Rev Infect Dis 1988, 10(4):867-878.
12. Woodford N., Ellington M.J., Coelho J.M., Turton J.F., Ward M.E., Brown S., et al. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents 2006, 27(4):351-353.
13. Higgins P.G., Lehmann M., Seifert H. Inclusion of OXA- 143 primers in a multiplex polymerase chain reaction (PCR) for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int J Antimicrob Agents 2010, 35:305.
14. Mendes R.E., Kiyota K.A., Monteiro J., Castanheira M., Andrade S.S., Gales A.C., et al. Rapid detection and identification of metallo-b-lactamase encoding genes by multiplex real-time PCR assay and melt curve analysis. JClin Microbiol 2007, 45(2):544-577.
15. Nordmann P., Poirel L., Carrër A., Toleman M.A., Walsh T.R. How to detect NDM-1 producers. JClin Microbiol 2011, 49(2):718-721.
16. Ruiz M., Marti S., Fernandez-Cuenca F., Pascual A., Vila J. Prevalence of IS(Aba1) in epidemiologically unrelated Acinetobacter baumanii clinical isolates. FEMS Microbiol Lett 2007, 274(1):63-66.
17. Verdet C., Benzerar Y., Gautier V., Adam O., Ould-Hocine Z., Arlet G. Emergence of DHA-1-producing Klebsiella spp. in the parisian region: genetic organization of the ampC and ampR genes originating from Morganella morganii. Antimicrobial Agents Chemother 2006, 50(2):607-617.
18. Messai Y., Iabadene H., Benhassine T., Alouache S., Tazir M., Gautier V., et al. Prevalence and characterization of extended-spectrum beta-lactamases in Klebsiella pneumoniae in Algiers hospitals (Algeria). Pathol Biol 2008, 56(5):319-325.
19. Kim J., Park Y.J., Kim S.I., Kang M.W., Lee S.O., Lee K.Y. Nosocomial outbreak by Proteus mirabilis producing extended-spectrum β-lactamase VEB-1 in a Korean university hospital. JAntimicrob Chemother 2004, 54(6):1144-1147.
20. Figueira V., Vaz-Moreira I., Silva M., Manaia C.M. Diversity and antibiotic resistance of Aeromonas spp. in drinking and waste water treatment plants. Water Res 2011, 45(17):5599-5611.
21. Guardabassi L., Dijkshoorn L., Collard J.M., Olsen J.E., Dalsgaard A. Distribution and in-vitro transfer of tetracycline resistance determinants in clinical and aquatic Acinetobacter strains. JMed Microbiol 2000, 49(10):929-936.
22. Murinda S.E., Ebner P.D., Nguyen L.T., Mathew A.G., Oliver S.P. Antimicrobial resistance and class 1 integrons in pathogenic Escherichia coli from dairy farms. Foodborne Pathog Dis 2005, 2(4):348-352.
23. Frank T., Gautier V., Talarmin A., Bercion R., Arlet G. Characterization of sulphonamide resistance genes and class 1 integron gene cassettes in Enterobacteriaceae, Central African Republic (CAR). JAntimicrob Chemother 2007, 59(4):742-745.
24. Šeputiene V., Povilonis J., Ruzauskas M., Pavilonis A., Suziedeliene E. Prevalence of trimethoprim resistance genes in Escherichia coli isolates of human and animal origin in Lithuania. JMed Microbiol 2010, 59(3):315-322.
25. OXA-23 in Acinetobacter baumannii. Antimicrobial Agents Chemother 2007, 51(4):1530-1533.
26. ADC in clinically relevant Acinetobacter baumannii strains resistant to cephalosporins. JMed Microbiol 2012, 61(8):1103-1108.
27. Valenzuela J.K., Thomas L., Partridge S.R., Van der Reijden T., Dijkshoorn L., Iredell J. Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii. JClin Microbiol 2007, 45(2):453-460.
28. Decré D., Burghoffer B., Gautier V., Petit J.C., Arlet G. [Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum beta-lactamases and strains with extended-spectrum activity of the chromosomal beta-lactamase]. JAntimicrob Chemother 2004, 54(5):881-888.
29. Van Belkum A., Tassios P.T., Dijkshoorn L., Haeggman S., Cookson B., Fry N.K., et al. European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group on Epidemiological Markers (ESGEM). Guidelines for the validation and application of typing methods for use in bacterial epidemiology. Clin Microbiol Infect 2007, 13(Suppl.3):1-46.
30. ème Rapport d'évaluation (Janvier à Décembre 2011): Surveillance de la résistance des bactéries aux antibiotiques 2012, Ministère de la Santé, Algérie.
31. Mesli E., Berrazeg M., Drissi M., Bekkhoucha S.N., Rolain J.M. Prevalence of carbapenemase-encoding genes including New Delhi metallo-β-lactamase in Acinetobacter species, Algeria. Int J Infect Dis 2013, 17(9):739-743.
32. Martins H.S., Bomfim M.R., França R.O., Farias L.M., Carvalho M.A., Serufo J.C., et al. Resistance markers and genetic diversity in Acinetobacter baumannii strains recovered from nosocomial bloodstream infections. Int J Environ Res Public Health 2014, 11(2):1465-1478.
33. Nordmann P., Poirel L., Walsh T.R., Livermore D.M. The emerging NDM carbapenemases. Trend Microbiol 2011, 19(12):588-595.
34. Mishra S.K., Rijal B.P., Pokhrel B.M. Emerging threat of multidrug resistant bugs - Acinetobacter calcoaceticus baumannii complex and methicillin resistant Staphylococcus aureus. BMC Res Notes 2013, 6:98.
35. Bakour S., Kempf M., Touati A., Ait Ameur A., Haouchine D., Sahli F., et al. Carbapenemase-producing Acinetobacter baumannii in two university hospitals in Algeria. JMed Microbiol 2012, 61(9):1341-1343.
36. Hornsey M., Wareham D.W. Invivo efficacy of glycopeptide-colistin combination therapies in a Galleria mellonella model of Acinetobacter baumannii infection. Antimicrobial Agents Chemother 2011, 55(7):3534-3537.
37. OXA-23 carbapenemase gene of Acinetobacter baumannii. Emerg Infect Dis 2010, 16(1):35-40.
38. OXA-58 carbapenemase-encoding genes in multidrug-resistant Acinetobacter baumannii isolates from University Hospital of Annaba, Algeria. Int J Antimicrob Agents 2012, 40(1):89-91.
39. Bakour S., Touati A., Bachiri T., Sahli F., Tiouit D., Naim M., et al. First report of 16S rRNA methylase ArmA-producing Acinetobacter baumannii and rapid spread of metallo-b-lactamase NDM-1 in Algerian hospitals. JInfect Chemother 2014, 20(11):696-701.
40. Turton J.F., Ward M.E., Woodford N., Kaufmann M.E., Pike R., Livermore D.M., et al. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol Lett 2006, 258(1):72-77.
41. OXA-58 gene in clinical isolates of Acinetobacter baumannii isolated from the USA. Clin Microbiol Infect 2012, 18(11):446-451.
42. Walther-Rasmussen J., Høiby N. [OXA-type carbapenemases]. JAntimicrob Chemother 2006, 7(3):373-383.
43. Pasteran F., Albornoz E., Faccone D., Gomez S., Valenzuela C., Morales M., et al. Emergence of NDM-1-producing Klebsiella pneumoniae in Guatemala. JAntimicrob Chemother 2012, 67(7):1795-1797.
44. Pérez J.A.E., Olarte-Escobar N.M., Castro-Cardozo B., Valderrama-Márquez I.A., Garzón Aguilar M.I., de la Barrera L.M., et al. Outbreak of NDM-1-producing Klebsiella pneumoniae in a neonatal unit in Colombia. Antimicrobial Agents Chemother 2013, 58(12):1957-1960.
45. NDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007. JAntimicrob Chemother 2011, 66(9):1998-2001.
46. Jiang M.J., Zhao S.P., Li J.M., Zhang F.S. Molecular epidemiological study and detection of multi-drug resistant Acinetobacter baumannii-related resistance genes. Afr J Microbiol Res 2013, 7(48):5496-5502.
47. Perez F., Hujer A.M., Hujer K.M., Decker B.K., Rather P.N., Bonomo R.A. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrobial Agents Chemother 2007, 51(10):3471-3484.
48. Strahilevitz J., Jacoby G.A., Hooper D.C., Robicsek A. Plasmid-mediated quinolone resistance: a multifaceted threat. Clin Microbiol Rev 2009, 22(4):664-689.
49. Taitt C.R., Leski T.A., Stockelman M.G., Craft D.W., Zurawski D.V., Kirkup B.C., et al. Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities. Antimicrobial Agents Chemother 2014, 58(2):767-781.
50. Su X.Z., Chen J., Mizushima T., Kuroda T., Tsuchiya T. AbeM, an H-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrobial Agents Chemother 2005, 49(10):4362-4364.
51. Mak J.K., Kim M.J., Pham J., Tapsall J., White P.A. Antibiotic resistance determinants in nosocomial strains of multidrug-resistant Acinetobacter baumannii. JAntimicrob Chemother 2009, 63(1):47-54.
52. Dally S., Lemuth K., Kaase M., Rupp S., Knabbe C., Weile J. DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates. Antimicrobial Agents Chemother 2013, 57(10):4761-4768.
53. Coyne S., Courvalin P., Périchon B. Efflux-mediated antibiotic resistance in Acinetobacter spp. Antimicrobial Agents Chemother 2011, 55(3):947-953.
54. Lin M.F., Chang K.C., Yang C.Y., Yang C.M., Xiao C.C., Kuo H.Y., et al. Role of integrons in antimicrobial susceptibility patterns of Acinetobacter baumannii. Jpn J Infect Dis 2010, 63(6):440-443.
55. Zarrilli R., Pournaras S., Giannouli M., Tsakris A. Global evolution of multidrug-resistant Acinetobacter baumannii clonal lineages. Int J Antimicrob Agents 2013, 41(1):11-19.