메뉴 건너뛰기




Volumn 38, Issue 4, 2015, Pages 1537-1545

Anti-inflammatory and Antioxidative Activities of Safranal in the Reduction of Renal Dysfunction and Damage that Occur in Diabetic Nephropathy

Author keywords

diabetic nephropathy; inflammation; oxidative stress; safranal

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CREATININE; GAMMA INTERFERON; GLUTATHIONE; HERBACEOUS AGENT; INTERLEUKIN 18; INTERLEUKIN 1BETA; NITRIC OXIDE; SAFRANAL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLOHEXENE DERIVATIVE; TERPENE;

EID: 84937252255     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-015-0128-y     Document Type: Article
Times cited : (37)

References (35)
  • 1
    • 84892659350 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • ADA (American Diabetes Association). 2014. Diagnosis and classification of diabetes mellitus. Diabetes Care 37(1): S81–S90.
    • (2014) Diabetes Care , vol.37 , Issue.1 , pp. S81-S90
  • 2
    • 84979860765 scopus 로고    scopus 로고
    • IDF Diabetes Atlas, 6 edition
    • IDF (International Diabetes Fedaration). 2014. IDF Diabetes Atlas, 6 edition, p 12.
    • (2014) p 12
  • 4
    • 84903448009 scopus 로고    scopus 로고
    • Effects of oral anti-diabetic agent sitagliptin on total antioxidant and oxidant status in rats with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXitVWqsb%2FM
    • Hazman, Ö., and S. Çelik. 2014. Effects of oral anti-diabetic agent sitagliptin on total antioxidant and oxidant status in rats with type 2 diabetes mellitus. Journal of Applied Biological Sciences 8(1): 31–37.
    • (2014) Journal of Applied Biological Sciences , vol.8 , Issue.1 , pp. 31-37
    • Hazman, Ö.1    Çelik, S.2
  • 5
    • 84856247093 scopus 로고    scopus 로고
    • Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC38XjvVWjurs%3D, PID: 20718759
    • Elmarakby, A.A., and J.C. Sullivan. 2012. Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. Cardiovascular Therapeutics 30: 49–59.
    • (2012) Cardiovascular Therapeutics , vol.30 , pp. 49-59
    • Elmarakby, A.A.1    Sullivan, J.C.2
  • 6
    • 84919667875 scopus 로고    scopus 로고
    • Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats
    • Elbe H., N. Vardi, M. Esrefoglu, B. Ates, S. Yologlu and C. Taskapan. 2014. Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats. Human and Experimental Toxicology: 1–14. DOI: 10.1177/0960327114531995.
    • (2014) Human and Experimental Toxicology
    • Elbe, H.1    Vardi, N.2    Esrefoglu, M.3    Ates, B.4    Yologlu, S.5    Taskapan, C.6
  • 7
    • 0028906034 scopus 로고
    • Role of TNF and IL-1 in the development of diabetic nephropathy
    • Hasegawa, G., K. Nakano, and M. Kondo. 1995. Role of TNF and IL-1 in the development of diabetic nephropathy. Nefrología 15: 1–4.
    • (1995) Nefrología , vol.15
    • Hasegawa, G.1    Nakano, K.2    Kondo, M.3
  • 10
    • 29244478599 scopus 로고    scopus 로고
    • Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents
    • COI: 1:CAS:528:DC%2BD28Xnt12iuw%3D%3D
    • Assimopoulou, A.N., Z. Sinakos, and V.P. Papageorgiou. 2005. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytotherpahy Research 19: 997–1000.
    • (2005) Phytotherpahy Research , vol.19 , pp. 997-1000
    • Assimopoulou, A.N.1    Sinakos, Z.2    Papageorgiou, V.P.3
  • 11
    • 84896336480 scopus 로고    scopus 로고
    • Evaluation of lung and bronchoalveolar lavage fluid oxidative stress indices for assessing the preventing effects of safranal on respiratory distress in diabetic rats. The Scientific World Journal
    • Samarghandian, S., R. Afshari, A. Sadati. 2014. Evaluation of lung and bronchoalveolar lavage fluid oxidative stress indices for assessing the preventing effects of safranal on respiratory distress in diabetic rats. The Scientific World Journal, Article ID 251378, 6. http://dx.doi.org/10.1155/251378.
    • (2014) Article ID , pp. 6
    • Samarghandian, S.1    Afshari, R.2    Sadati, A.3
  • 12
    • 84939948222 scopus 로고    scopus 로고
    • Investigation of the anti-inflammatory effects of safranal on high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model
    • PID: 24429913
    • Hazman, O., and S. Ovalı. 2014. Investigation of the anti-inflammatory effects of safranal on high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Inflammation. doi:10.1007/s10753-014-0065-1.
    • (2014) Inflammation
    • Hazman, O.1    Ovalı, S.2
  • 13
    • 81255167465 scopus 로고    scopus 로고
    • Anti-hyperglycemic effects of saffron and its active constituents, crocin and safranal, in alloxan-induced diabetic rats
    • Kainbakht, S., and R. Hajiaghaee. 2011. Anti-hyperglycemic effects of saffron and its active constituents, crocin and safranal, in alloxan-induced diabetic rats. Journal of Medicinal Plant 10(39): 82–89.
    • (2011) Journal of Medicinal Plant , vol.10 , Issue.39 , pp. 82-89
    • Kainbakht, S.1    Hajiaghaee, R.2
  • 14
    • 0030047682 scopus 로고    scopus 로고
    • Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro
    • COI: 1:CAS:528:DyaK28XhtVCisLw%3D, PID: 8620447
    • Escribano, J., G.L. Alonso, M. Coca-Prados, and J.A. Fernandez. 1996. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Letters 100: 23–30.
    • (1996) Cancer Letters , vol.100 , pp. 23-30
    • Escribano, J.1    Alonso, G.L.2    Coca-Prados, M.3    Fernandez, J.A.4
  • 15
    • 77954497958 scopus 로고    scopus 로고
    • Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats
    • COI: 1:CAS:528:DC%2BC3cXhtValt7zF, PID: 20013822
    • Imenshahidi, M., H. Hosseinzadeh, and Y. Javadpour. 2010. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytotherapy Research 24(7): 990–994.
    • (2010) Phytotherapy Research , vol.24 , Issue.7 , pp. 990-994
    • Imenshahidi, M.1    Hosseinzadeh, H.2    Javadpour, Y.3
  • 16
    • 65549131015 scopus 로고    scopus 로고
    • The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Experimental Diabetes Research
    • Zhang, M., M.Y. Lv, J. Lı, Z.G. Xu, L. Chen. 2008. The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Experimental Diabetes Research, Article ID 704045, 1–9.
    • (2008) Article ID
    • Zhang, M.1    Lv, M.Y.2    Lı, J.3    Xu, Z.G.4    Chen, L.5
  • 17
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 7(72): 248–254.
    • (1976) Analytical Biochemistry , vol.7 , Issue.72 , pp. 248-254
    • Bradford, M.M.1
  • 18
    • 0346023040 scopus 로고    scopus 로고
    • A novel automated method to measure total antioxidant response against potent free radical reactions
    • COI: 1:CAS:528:DC%2BD2cXjtFChtg%3D%3D, PID: 14725941
    • Erel, Ö. 2004. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical Biochemistry 37(2): 112–119.
    • (2004) Clinical Biochemistry , vol.37 , Issue.2 , pp. 112-119
    • Erel, Ö.1
  • 19
    • 29144527533 scopus 로고    scopus 로고
    • A new automated colorimetric method for measuring total oxidant status
    • COI: 1:CAS:528:DC%2BD2MXhtlaisbjL, PID: 16214125
    • Erel, Ö. 2005. A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry 38(12): 1103–1111.
    • (2005) Clinical Biochemistry , vol.38 , Issue.12 , pp. 1103-1111
    • Erel, Ö.1
  • 20
    • 0035709008 scopus 로고    scopus 로고
    • A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
    • COI: 1:CAS:528:DC%2BD3MXhtFemsrs%3D, PID: 11178938
    • Miranda, K.M., M.G. Espey, and D.A. Wink. 2001. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5: 62–71.
    • (2001) Nitric Oxide , vol.5 , pp. 62-71
    • Miranda, K.M.1    Espey, M.G.2    Wink, D.A.3
  • 22
    • 78651354134 scopus 로고    scopus 로고
    • Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet
    • Amin, K.A., H.H. Kamel, and M.A. Eltawab. 2011. Protective effect of Garcinia against renal oxidative stress and biomarkers induced by high fat and sucrose diet. Lipids in Health and Disease 10(6): 1–13.
    • (2011) Lipids in Health and Disease , vol.10 , Issue.6
    • Amin, K.A.1    Kamel, H.H.2    Eltawab, M.A.3
  • 23
    • 84887145854 scopus 로고    scopus 로고
    • Red-Koji fermented red ginseng ameliorates high fat diet-induced metabolic disorders in mice
    • PID: 24177708
    • Kim, C.M., S.J. Yi, I.J. Cho, and S.K. Ku. 2013. Red-Koji fermented red ginseng ameliorates high fat diet-induced metabolic disorders in mice. Nutrients 5: 4316–4332.
    • (2013) Nutrients , vol.5 , pp. 4316-4332
    • Kim, C.M.1    Yi, S.J.2    Cho, I.J.3    Ku, S.K.4
  • 24
    • 84904490449 scopus 로고    scopus 로고
    • Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney
    • COI: 1:CAS:528:DC%2BC2cXht1OrurnK, PID: 25016146
    • Gai, Z., C. Hiller, S.H. Chin, L. Hofstetter, B. Stieger, D. Konrad, and G.A. Kullak-Ublick. 2014. Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney. Biochimica et Biophysica Acta 1842: 1870–1878.
    • (2014) Biochimica et Biophysica Acta , vol.1842 , pp. 1870-1878
    • Gai, Z.1    Hiller, C.2    Chin, S.H.3    Hofstetter, L.4    Stieger, B.5    Konrad, D.6    Kullak-Ublick, G.A.7
  • 25
    • 84921982992 scopus 로고    scopus 로고
    • Protective effects of saffron (its active constituent, crocin) on nephropathy in streptozotocin-induced diabetic rats
    • PID: 24925368
    • Altinoz, E., Z. Oner, H. Elbe, Y. Cigremis, and Y. Turkoz. 2014. Protective effects of saffron (its active constituent, crocin) on nephropathy in streptozotocin-induced diabetic rats. Human and Experimental Toxicology. doi:10.1177/0960327114538989.
    • (2014) Human and Experimental Toxicology
    • Altinoz, E.1    Oner, Z.2    Elbe, H.3    Cigremis, Y.4    Turkoz, Y.5
  • 28
    • 0038748305 scopus 로고    scopus 로고
    • Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD3sXktVOgsLo%3D, PID: 12759891
    • Moriwaki, Y., T. Yamamoto, Y. Shibutani, E. Aoki, Z. Tsutsumi, S. Takahashi, H. Okamura, M. Koga, M. Fukuchi, and T. Hada. 2003. Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. Metabolism 52: 605–608.
    • (2003) Metabolism , vol.52 , pp. 605-608
    • Moriwaki, Y.1    Yamamoto, T.2    Shibutani, Y.3    Aoki, E.4    Tsutsumi, Z.5    Takahashi, S.6    Okamura, H.7    Koga, M.8    Fukuchi, M.9    Hada, T.10
  • 30
    • 84890076166 scopus 로고    scopus 로고
    • Obesity and CKD progression: hard facts on fat CKD patients
    • PID: 24179007
    • Mallamaci, F., and G. Tripepi. 2013. Obesity and CKD progression: hard facts on fat CKD patients. Nephrology, Dialysis, Transplantation 28(4): iv105–iv108.
    • (2013) Nephrology, Dialysis, Transplantation , vol.28 , Issue.4 , pp. iv105-iv108
    • Mallamaci, F.1    Tripepi, G.2
  • 31
    • 84885956835 scopus 로고    scopus 로고
    • Obesity, immunomodulation and chronic kidney disease
    • PID: 23751262
    • Börgeson, E., and K. Sharma. 2013. Obesity, immunomodulation and chronic kidney disease. Current Opinion in Pharmacology 13: 618–624.
    • (2013) Current Opinion in Pharmacology , vol.13 , pp. 618-624
    • Börgeson, E.1    Sharma, K.2
  • 33
    • 84896324646 scopus 로고    scopus 로고
    • Increased concentration of C-reactive protein in obese patients with type 2 diabetes is associated with obesity and presence of diabetes but not with macrovascular and microvascular complications or glycemic control
    • COI: 1:CAS:528:DC%2BC2cXktFentL8%3D, PID: 24197824
    • Fronczyk, A., P. Molęda, K. Safranow, W. Piechota, and L. Majkowska. 2014. Increased concentration of C-reactive protein in obese patients with type 2 diabetes is associated with obesity and presence of diabetes but not with macrovascular and microvascular complications or glycemic control. Inflammation 37(2): 349–357.
    • (2014) Inflammation , vol.37 , Issue.2 , pp. 349-357
    • Fronczyk, A.1    Molęda, P.2    Safranow, K.3    Piechota, W.4    Majkowska, L.5
  • 34
    • 52149122499 scopus 로고    scopus 로고
    • Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats
    • COI: 1:CAS:528:DC%2BD1MXisFems7g%3D, PID: 18812693
    • Jeong, K.H., T.W. Lee, C.G. Ihm, S.H. Lee, J.Y. Moon, and S.J. Lim. 2009. Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats. American Journal of Nephrology 29: 274–282.
    • (2009) American Journal of Nephrology , vol.29 , pp. 274-282
    • Jeong, K.H.1    Lee, T.W.2    Ihm, C.G.3    Lee, S.H.4    Moon, J.Y.5    Lim, S.J.6
  • 35
    • 79961017532 scopus 로고    scopus 로고
    • Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats
    • COI: 1:CAS:528:DC%2BC3MXht1SqtrfK, PID: 21812977
    • Noeman, S.A., H.E. Hamooda, and A.A. Baalash. 2011. Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats. Diabetology and Metabolic Syndrome 3: 17.
    • (2011) Diabetology and Metabolic Syndrome , vol.3 , pp. 17
    • Noeman, S.A.1    Hamooda, H.E.2    Baalash, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.