Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors

European Journal of Medicinal Chemistry

Volumn 101, Issue , 2015, Pages 525-533

  Yu, Le Mao ^a   Zhang, Xiao Ru ^a   Li, Xiao Bing ^a   Yang, Yuan ^a   Wei, Hong Yu ^b   He, Xi Xin ^b   Gu, Lian Quan ^a   Huang, Zhi Shu ^a   Pommier, Yves ^c   An, Lin Kun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Anticancer; DNA topoisomerase; Indolizinoquinolinedione; Inhibitor

Indexed keywords

2 (PIPERIDIN 1 YL)ETHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; 2 (PYRIDIN 2 YL)ETHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; 2 (PYRROLIDIN 1 YL)ETHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; 2 BROMOETHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G] QUINOLINE 6 CARBOXYLATE; 2 BROMOPROPYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G] QUINOLINE 6 CARBOXYLATE; 3 (PIPERIDIN 1 YL)PROPYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; 3 MORPHOLINOPROPYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXYLATE; 5,12 DIOXO N (3 PHENYLPROPYL) 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; 5,12 DIOXO N PHENETHYL 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; 5,12 DIOXO N [2 (PIPERIDIN 1 YL)ETHYL] 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; 5,12 DIOXO N [3 (PIPERIDIN 1 YL)PROPYL] 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; 5,12 DIOXO N [3 (PYRROLIDIN 1 YL)PROPYL] 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; 6 (4 METHYLPIPERAZINE 1 CARBONYL)INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 6 (MORPHOLINE 4 CARBONYL)INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; 6 (PIPERIDINE 1 CARBONYL)INDOLIZINO[2,3 G]QUINOLINE 5,12 DIONE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; INDOLE DERIVATIVE; N (2 MORPHOLINOETHYL) 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N (3 MORPHOLINOPROPYL) 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 (1H IMIDAZOL 1 YL)ETHYL] 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 (4 METHYLPIPERAZIN 1 YL)ETHYL] 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL] 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 (PYRROLIDIN 1 YL)ETHYL] 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [2 DIMETHYLAMINO)ETHYL] 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [3 (4 METHYLPIPERAZIN 1 YL)PROPYL] 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [3 (DIETHYLAMINO)PROPYL] 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N [3 (DIMETHYLAMINO)PROPYL] 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; N,N DIETHYL 5,12 DIOXO 5,12 DIHYDROINDOLIZINO[2,3 G]QUINOLINE 6 CARBOXAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; DNA TOPOISOMERASE; INDOLIZINE DERIVATIVE; N-(3-(4-METHYLPIPERAZIN-1-YL)PROPYL)-5,12-DIOXO-5,12-DIHYDROINDOLIZINO(2,3-G)QUINOLINE-6-CARBOXAMIDE; QUINOLONE DERIVATIVE;

A549 CELL LINE; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; HL 60 CELL LINE; HUMAN; HUMAN CELL; MTT ASSAY; BIOCATALYSIS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; BIOCATALYSIS; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLIZINES; MOLECULAR STRUCTURE; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TUMOR CELLS, CULTURED;

EID: 84937205162     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.07.007     Document Type: Article

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