Retinal vascular fractals predict long-term microvascular complications in type 1 diabetes mellitus: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

Diabetologia

Volumn 57, Issue 10, 2014, Pages 2215-2221

  Broe, Rebecca ^a,b   Rasmussen, Malin L ^a,b   Frydkjaer Olsen, Ulrik ^a,b   Olsen, Birthe S ^c,d   Mortensen, Henrik B ^c,d   Peto, Tunde ^b,e   Grauslund, Jakob ^a,b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

Biomarkers; Childhood diabetes; Complications; Type 1 diabetes mellitus

Indexed keywords

HEMOGLOBIN A1C; BIOLOGICAL MARKER;

ADOLESCENT; AGE; ALBUMINURIA; ARTICLE; ARTIFACT; BODY MASS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DANISH CITIZEN; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DISEASE DURATION; EYE PHOTOGRAPHY; FEMALE; FOLLOW UP; FRACTAL ANALYSIS; HUMAN; IMAGE ANALYSIS; IMAGING SOFTWARE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; OPHTHALMIC ESTHESIOMETER; OPTICAL COHERENCE TOMOGRAPHY DEVICE; PREDICTION; PRIORITY JOURNAL; PROLIFERATIVE RETINOPATHY; RETINA BLOOD VESSEL; SEX; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; VIBRATION SENSE; ADULT; COMPLICATION; DIABETES COMPLICATIONS; DIABETIC RETINOPATHY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; YOUNG ADULT;

ADULT; BIOLOGICAL MARKERS; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; FEMALE; HUMANS; MALE; RETINAL VESSELS; YOUNG ADULT;

EID: 84937199120     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3317-6     Document Type: Article

References (33)

1. Pambianco G, Costacou T, Ellis D, Becker DJ, Klein R, Orchard TJ (2006) The 30-year natural history of type 1 diabetes complications: the Pittsburgh Epidemiology of Diabetes Complications Study experience. Diabetes 55:1463–1469
2. Grauslund J, Green A, Sjolie AK (2009) Prevalence and 25 year incidence of proliferative retinopathy among Danish type 1 diabetic patients. Diabetologia 52:1829–1835
3. Grauslund J, Hodgson L, Kawasaki R, Green A, Sjolie AK, Wong TY (2009) Retinal vessel calibre and micro- and macrovascular complications in type 1 diabetes. Diabetologia 52:2213–2217
4. Wong TY, Shankar A, Klein R, Klein BE (2004) Retinal vessel diameters and the incidence of gross proteinuria and renal insufficiency in people with type 1 diabetes. Diabetes 53:179–184
5. Ding J, Cheung CY, Ikram MK et al (2012) Early retinal arteriolar changes and peripheral neuropathy in diabetes. Diabetes Care 35:1098–1104
6. Klein R, Klein BE, Moss SE, Wong TY, Sharrett AR (2006) Retinal vascular caliber in persons with type 2 diabetes: the Wisconsin Epidemiological Study of Diabetic Retinopathy: XX. Ophthalmology 113:1488–1498
7. Cheung CY, Lamoureux E, Ikram MK et al (2012) Retinal vascular geometry in Asian persons with diabetes and retinopathy. J Diabetes Sci Technol 6:595–605
8. Masters BR (2004) Fractal analysis of the vascular tree in the human retina. Annu Rev Biomed Eng 6:427–452
9. Cheung N, Donaghue KC, Liew G et al (2009) Quantitative assessment of early diabetic retinopathy using fractal analysis. Diabetes Care 32:106–110
10. Daxer A (1993) The fractal geometry of proliferative diabetic retinopathy: implications for the diagnosis and the process of retinal vasculogenesis. Curr Eye Res 12:1103–1109
11. Grauslund J, Green A, Kawasaki R, Hodgson L, Sjolie AK, Wong TY (2010) Retinal vascular fractals and microvascular and macrovascular complications in type 1 diabetes. Ophthalmology 117:1400–1405
12. Lim LS, Cheung CY, Sabanayagam C et al (2013) Structural changes in the retinal microvasculature and renal function. Invest Ophthalmol Vis Sci 54:2970–2976
13. Lim SW, Cheung N, Wang JJ et al (2009) Retinal vascular fractal dimension and risk of early diabetic retinopathy: a prospective study of children and adolescents with type 1 diabetes. Diabetes Care 32:2081–2083
14. Broe R, Rasmussen ML, Frydkjaer-Olsen U et al (2013) The 16-year incidence, progression and regression of diabetic retinopathy in a young population-based Danish cohort with type 1 diabetes mellitus: the Danish cohort of pediatric diabetes 1987 (DCPD1987). Acta Diabetol 51:413–420
15. Olsen BS, Johannesen J, Sjolie AK et al (1999) Metabolic control and prevalence of microvascular complications in young Danish patients with Type 1 diabetes mellitus. Danish Study Group of Diabetes in Childhood. Diabet Med 16:79–85
16. Olsen BS, Sjolie A, Hougaard P et al (2000) A 6-year nationwide cohort study of glycaemic control in young people with type 1 diabetes. Risk markers for the development of retinopathy, nephropathy and neuropathy. Danish Study Group of Diabetes in Childhood. J Diabetes Complicat 14:295–300
17. Mortensen HB, Marinelli K, Norgaard K et al (1990) A nation-wide cross-sectional study of urinary albumin excretion rate, arterial blood pressure and blood glucose control in Danish children with type 1 diabetes mellitus. Danish Study Group of Diabetes in Childhood. Diabet Med 7:887–897
18. Aldington SJ, Kohner EM, Meuer S, Klein R, Sjolie AK (1995) Methodology for retinal photography and assessment of diabetic retinopathy: the EURODIAB IDDM complications study. Diabetologia 38:437–444
19. Macgillivray TJ, Patton N, Doubal FN, Graham C, Wardlaw JM (2007) Fractal analysis of the retinal vascular network in fundus images. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference, pp. 6456–6459
20. Stosic T, Stosic BD (2006) Multifractal analysis of human retinal vessels. IEEE Trans Med Imaging 25:1101–1107
21. Mainster MA (1990) The fractal properties of retinal vessels: embryological and clinical implications. Eye (Lond) 4(Pt 1):235–241
22. Knudtson MD, Lee KE, Hubbard LD, Wong TY, Klein R, Klein BE (2003) Revised formulas for summarizing retinal vessel diameters. Curr Eye Res 27:143–149
23. Anonymous (1985) Early Treatment Diabetic Retinopathy Study (ETDRS): manual of operations. U.S. Department of Commerce, National Technical Information Service
24. Zenere BM, Arcaro G, Saggiani F, Rossi L, Muggeo M, Lechi A (1995) Noninvasive detection of functional alterations of the arterial wall in IDDM patients with and without microalbuminuria. Diabetes Care 18:975–982
25. Tesfamariam B, Jakubowski JA, Cohen RA (1989) Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2. Am J Physiol 257:H1327–H1333
26. Harrison DG (1997) Endothelial function and oxidant stress. Clin Cardiol 20, II-11–17
27. Vervoort G, Wetzels JF, Lutterman JA, van Doorn LG, Berden JH, Smits P (1999) Elevated skeletal muscle blood flow in noncomplicated type 1 diabetes mellitus: role of nitric oxide and sympathetic tone. Hypertension 34:1080–1085
28. Grunwald JE, Riva CE, Brucker AJ, Sinclair SH, Petrig BL (1984) Altered retinal vascular response to 100% oxygen breathing in diabetes mellitus. Ophthalmology 91:1447–1452
29. The Diabetes Control and Complications Trial Research Group (1995) The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial. Diabetes 44:968–983
30. Reichard P (1995) Are there any glycemic thresholds for the serious microvascular diabetic complications? J Diabetes Complicat 9:25–30
31. Liew G, Wang JJ, Cheung N et al (2008) The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure. Ophthalmology 115:1951–1956
32. Azemin MZ, Kumar DK, Wong TY et al (2012) Age-related rarefaction in the fractal dimension of retinal vessel. Neurobiol Aging 33(194):e191–e194
33. Cosatto VF, Liew G, Rochtchina E et al (2010) Retinal vascular fractal dimension measurement and its influence from imaging variation: results of two segmentation methods. Curr Eye Res 35:850–856