IKKβ enforces a LIN28B/TCF7L2 positive feedback loop that promotes cancer cell stemness and metastasis

Cancer Research

Volumn 75, Issue 8, 2015, Pages 1725-1735

  Chen, Chong ^a,b   Cao, Fengqi ^a,b   Bai, Lipeng ^a,b   Liu, Yan ^a,b   Xie, Junling ^a,b   Wang, Wei ^a,b   Si, Qin ^a,b   Yang, Jian ^c   Chang, Antao ^c   Liu, Dong ^d   Liu, Dachuan ^d   Chuang, Tsung Hsien ^e   Xiang, Rong ^c   Luo, Yunping ^a,b  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c NANKAI UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; I KAPPA B KINASE BETA; IMD 0354; MESSENGER RNA; PACLITAXEL; PROTEIN LIN28B; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG; WNT PROTEIN; I KAPPA B KINASE; LIN28B PROTEIN, HUMAN; RNA BINDING PROTEIN; TCF7L2 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL STEMNESS; CANCER GROWTH; CANCER PATIENT; CARCINOGENESIS; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTRON; LIN28B GENE; LUNG CANCER; LUNG METASTASIS; MOUSE; NONHUMAN; ONCOLOGICAL PARAMETERS; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; RNA TRANSLATION; SIGNAL TRANSDUCTION; ANIMAL; CANCER STEM CELL; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; MCF 7 CELL LINE; METABOLISM; METASTASIS; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; SCID MOUSE; TUMOR CELL CULTURE;

ANIMALS; CELL PROLIFERATION; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; MCF-7 CELLS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; RNA-BINDING PROTEINS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; TUMOR CELLS, CULTURED;

EID: 84937151454     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-2111     Document Type: Article

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