Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis

Redox Biology

Volumn 6, Issue , 2015, Pages 80-92

  Verma, Ajeet Kumar ^a   Yadav, Arti ^a   Dewangan, Jayant ^a   Singh, Sarvendra Vikram ^a   Mishra, Manisha ^b   Singh, Pradhyumna Kumar ^b   Rath, Srikanta Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

Author keywords

Differential expression; ERK inhibitor; Isoniazid; Oxidative stress; Phosphorylation

Indexed keywords

CASPASE; ISONIAZID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; HEAT SHOCK PROTEIN; NFE2L2 PROTEIN, HUMAN; TUBERCULOSTATIC AGENT;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY ASSAY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC VARIABILITY; IC50; INTRACELLULAR SIGNALING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; VALIDATION STUDY; AGONISTS; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER CELL; METABOLISM; PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTITUBERCULAR AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HEPATOCYTES; HUMANS; ISONIAZID; METABOLIC NETWORKS AND PATHWAYS; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84937128067     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2015.06.020     Document Type: Article

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