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Volumn 35, Issue 4, 2016, Pages 783-790

Potential protective effects of l-carnitine against neuromuscular ischemia-reperfusion injury: From experimental data to potential clinical applications

Author keywords

Anti inflammatory; Antioxidant; Ischemia reperfusion injury; L carnitine

Indexed keywords

ACETYLCYSTEINE; ADENOSINE; ALPHA TOCOPHEROL; ASCORBIC ACID; AZATHIOPRINE; CARNITINE; CARNITINE DERIVATIVE; GLYCINE PROPIONYLCARNITINE; LEVACECARNINE; PROPIONYLCARNITINE; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 84937127979     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2015.07.001     Document Type: Review
Times cited : (22)

References (78)
  • 1
    • 0034137995 scopus 로고    scopus 로고
    • Endothelium functions in ischemia reperfusion (a literature review)
    • Petrishchev N.N., Vlasov T.D. Endothelium functions in ischemia reperfusion (a literature review). Ross FiziolZhIm Im Sechenova 2000, 86:148-163.
    • (2000) Ross FiziolZhIm Im Sechenova , vol.86 , pp. 148-163
    • Petrishchev, N.N.1    Vlasov, T.D.2
  • 2
    • 56449100005 scopus 로고    scopus 로고
    • Remote ischemic preconditioning: a novel protective method from ischemia reperfusioninjury-a review
    • Tapuria N., Kumar Y., Habib M.M., Abu Amara M., Seifalian A.M., Davidson B.R. Remote ischemic preconditioning: a novel protective method from ischemia reperfusioninjury-a review. J Surg Res 2008, 150:304-330.
    • (2008) J Surg Res , vol.150 , pp. 304-330
    • Tapuria, N.1    Kumar, Y.2    Habib, M.M.3    Abu Amara, M.4    Seifalian, A.M.5    Davidson, B.R.6
  • 4
    • 34249724327 scopus 로고    scopus 로고
    • New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle
    • Stephens F.B., Constantin-Teodosiu D., Greenhaff P.L. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol 2007, 581:431-444.
    • (2007) J Physiol , vol.581 , pp. 431-444
    • Stephens, F.B.1    Constantin-Teodosiu, D.2    Greenhaff, P.L.3
  • 5
    • 0031953601 scopus 로고    scopus 로고
    • Calcium in ischemic cell death
    • Kristian T., Siesjo B.K. Calcium in ischemic cell death. Stroke 1998, 29:705-718.
    • (1998) Stroke , vol.29 , pp. 705-718
    • Kristian, T.1    Siesjo, B.K.2
  • 6
    • 0028217760 scopus 로고
    • Ions and energy in mammalian brain
    • Erecinska M., Silver I.A. Ions and energy in mammalian brain. Prog Neurobiol 1994, 43:37-71.
    • (1994) Prog Neurobiol , vol.43 , pp. 37-71
    • Erecinska, M.1    Silver, I.A.2
  • 7
    • 0021981842 scopus 로고
    • Effect of anoxia on ion distribution in the brain
    • Hansenc A.J. Effect of anoxia on ion distribution in the brain. Physiol Rev 1985, 65:101-148.
    • (1985) Physiol Rev , vol.65 , pp. 101-148
    • Hansenc, A.J.1
  • 8
    • 1542317747 scopus 로고    scopus 로고
    • Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection
    • Bambrick L., Kristian T., Fiskum G. Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochem Res 2004, 29:601-608.
    • (2004) Neurochem Res , vol.29 , pp. 601-608
    • Bambrick, L.1    Kristian, T.2    Fiskum, G.3
  • 9
    • 84872486948 scopus 로고    scopus 로고
    • Molecular mechanisms of ischemia-reperfusion injury in brain. Pivotal role of the mitochondrial membrane potential in reactive oxygen specious generation
    • Sanderson T.H., Reynolds C.A., Kumar R., Przyklenk K., Hüttemann M. Molecular mechanisms of ischemia-reperfusion injury in brain. Pivotal role of the mitochondrial membrane potential in reactive oxygen specious generation. Mol Neurobiol 2013, 47:9-23.
    • (2013) Mol Neurobiol , vol.47 , pp. 9-23
    • Sanderson, T.H.1    Reynolds, C.A.2    Kumar, R.3    Przyklenk, K.4    Hüttemann, M.5
  • 12
    • 0023220472 scopus 로고
    • Calcium in the mitochondria following brief ischemia of gerbil brain
    • Dux E., Mies G., Hossmann K.A., Siklos L. Calcium in the mitochondria following brief ischemia of gerbil brain. Neurosci Lett 1987, 78:295-300.
    • (1987) Neurosci Lett , vol.78 , pp. 295-300
    • Dux, E.1    Mies, G.2    Hossmann, K.A.3    Siklos, L.4
  • 13
    • 0028090533 scopus 로고
    • The calcium content of mitochondria from brain subregions following short-term forebrain ischemia and recirculation in the rat
    • Zaidan E., Sims N.R. The calcium content of mitochondria from brain subregions following short-term forebrain ischemia and recirculation in the rat. J Neurochem 1994, 63:1812-1819.
    • (1994) J Neurochem , vol.63 , pp. 1812-1819
    • Zaidan, E.1    Sims, N.R.2
  • 15
    • 0026635016 scopus 로고
    • The role of glutamate antagonists for the treatment of CNS injury
    • Bullock R., Fujisawa H. The role of glutamate antagonists for the treatment of CNS injury. J Neurotrauma 1992, 2:443-462.
    • (1992) J Neurotrauma , vol.2 , pp. 443-462
    • Bullock, R.1    Fujisawa, H.2
  • 16
    • 84916618668 scopus 로고    scopus 로고
    • Molecular identity of mitochondrial permeability transition pore and its role in ischemia reperfusion injury
    • Morciano G., Giorgi C., Bonora M., Punzetti S., Parasini R., Wieckowski M.R., et al. Molecular identity of mitochondrial permeability transition pore and its role in ischemia reperfusion injury. J Mol Cell Cardiol 2015, 78:142-153.
    • (2015) J Mol Cell Cardiol , vol.78 , pp. 142-153
    • Morciano, G.1    Giorgi, C.2    Bonora, M.3    Punzetti, S.4    Parasini, R.5    Wieckowski, M.R.6
  • 17
    • 0037245709 scopus 로고    scopus 로고
    • Oxidative stress induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of bax: resistance of quiescent cells to oxidative stress
    • Naderi J., Hung M., Pandey S. Oxidative stress induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of bax: resistance of quiescent cells to oxidative stress. Apoptosis 2003, 8:91-100.
    • (2003) Apoptosis , vol.8 , pp. 91-100
    • Naderi, J.1    Hung, M.2    Pandey, S.3
  • 18
    • 0029116916 scopus 로고
    • The mitochondrial permeability transition
    • Zoratti M., Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta 1995, 1241:139-176.
    • (1995) Biochim Biophys Acta , vol.1241 , pp. 139-176
    • Zoratti, M.1    Szabo, I.2
  • 19
    • 82855182299 scopus 로고    scopus 로고
    • Ischemia/reperfusion injury and cardioprotective mechanisms: role of mitochondria and reactive oxygen species
    • Perrelli M.G., Pagliaro P., Penna C. Ischemia/reperfusion injury and cardioprotective mechanisms: role of mitochondria and reactive oxygen species. World J Cardiol 2011, 3:186-200.
    • (2011) World J Cardiol , vol.3 , pp. 186-200
    • Perrelli, M.G.1    Pagliaro, P.2    Penna, C.3
  • 20
    • 0021024932 scopus 로고
    • Carnitine metabolism and functions
    • Bremer J. Carnitine metabolism and functions. Physiol Rev 1983, 63:1420-1480.
    • (1983) Physiol Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 24
    • 84858077778 scopus 로고    scopus 로고
    • Carnitine derivatives: clinical usefulness
    • Malaguarnera M. Carnitine derivatives: clinical usefulness. Curr Opin Gastroenterol 2012, 28:166-176.
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 166-176
    • Malaguarnera, M.1
  • 25
    • 0003077423 scopus 로고    scopus 로고
    • Lipids of physiologic significance
    • Murray RK, Granner DK, Mayes PA, Rodwell VW (Eds), 25th edn. Appleton and Lange, Stanford
    • Mayes PA. Lipids of physiologic significance. In: Murray RK, Granner DK, Mayes PA, Rodwell VW (Eds), Harper's biochemistry. 25th edn. Appleton and Lange, Stanford, pp. 160-171.
    • Harper's biochemistry , pp. 160-171
    • Mayes, P.A.1
  • 26
    • 3342967838 scopus 로고    scopus 로고
    • Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage
    • Kristián T. Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage. Cell Calcium 2004, 36:221-233.
    • (2004) Cell Calcium , vol.36 , pp. 221-233
    • Kristián, T.1
  • 27
    • 30544455318 scopus 로고    scopus 로고
    • Antioxidant and antiradical activities of L-carnitine
    • Gülҫin I˙ Antioxidant and antiradical activities of L-carnitine. Life Sci 2006, 78:803-811.
    • (2006) Life Sci , vol.78 , pp. 803-811
    • Gülsin, I.1
  • 28
    • 0020423164 scopus 로고
    • The distribution and role of carnitine in the mammalian brain
    • Shug A.L., Schmidt M.J., Golden G.T., Fariello R.T. The distribution and role of carnitine in the mammalian brain. Life Sci 1982, 31:2869-2874.
    • (1982) Life Sci , vol.31 , pp. 2869-2874
    • Shug, A.L.1    Schmidt, M.J.2    Golden, G.T.3    Fariello, R.T.4
  • 30
    • 0035209172 scopus 로고    scopus 로고
    • Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier
    • Kido Y., Tamai I., Ohnari A., Sai Y., Kagami T., Nezu J., et al. Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. J Neurochem 2001, 79:959-969.
    • (2001) J Neurochem , vol.79 , pp. 959-969
    • Kido, Y.1    Tamai, I.2    Ohnari, A.3    Sai, Y.4    Kagami, T.5    Nezu, J.6
  • 32
    • 0035976362 scopus 로고    scopus 로고
    • Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity
    • Binienda Z.K., Ali S.F. Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity. Toxicol Lett 2001, 125:67-73.
    • (2001) Toxicol Lett , vol.125 , pp. 67-73
    • Binienda, Z.K.1    Ali, S.F.2
  • 33
    • 0035888178 scopus 로고    scopus 로고
    • Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats
    • Ando S., Tadenuma T., Tanaka Y., Fukui F., Kobayashi S., Ohashi Y., et al. Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. J Neurosci Res 2001, 66:266-271.
    • (2001) J Neurosci Res , vol.66 , pp. 266-271
    • Ando, S.1    Tadenuma, T.2    Tanaka, Y.3    Fukui, F.4    Kobayashi, S.5    Ohashi, Y.6
  • 34
    • 0033653231 scopus 로고    scopus 로고
    • Acetyl L-carnitine physical-chemical, metabolic and therapeutic properties: relevance for its mode of action in alzheimer's disease and geriatric depression
    • Pettegrew J.W., Levine J., McClure R.J. Acetyl L-carnitine physical-chemical, metabolic and therapeutic properties: relevance for its mode of action in alzheimer's disease and geriatric depression. Mol Psych 2000, 5:616-632.
    • (2000) Mol Psych , vol.5 , pp. 616-632
    • Pettegrew, J.W.1    Levine, J.2    McClure, R.J.3
  • 35
    • 0032875579 scopus 로고    scopus 로고
    • Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion
    • Calvani M., Arrigoni-Mortelli E. Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int J Tissue React 1999, 21:1-6.
    • (1999) Int J Tissue React , vol.21 , pp. 1-6
    • Calvani, M.1    Arrigoni-Mortelli, E.2
  • 36
    • 0033510014 scopus 로고    scopus 로고
    • Mitochondrial in neurodegeneration: acute ischemia and chronic neurodegenerative disease
    • Fiskum G, Murphy AN, Beal MF. Mitochondrial in neurodegeneration: acute ischemia and chronic neurodegenerative disease. J Cereb Blood Flow Metab1999;19; 351-369.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 351-369
    • Fiskum, G.1    Murphy, A.N.2    Beal, M.F.3
  • 37
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan P.H. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001, 21:2-14.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 38
    • 0026667916 scopus 로고
    • Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine
    • Rosenthal RE, Williams R, Bogaert YE, Getson PR, Fiskum G. Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine. Stroke1992; 23:1312-1318.
    • (1992) Stroke , vol.23 , pp. 1312-1318
    • Rosenthal, R.E.1    Williams, R.2    Bogaert, Y.E.3    Getson, P.R.4    Fiskum, G.5
  • 39
    • 0025026205 scopus 로고
    • Aging brain: effect of acetyl-carnitine treatment on the rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy
    • Aureli T., Miccheli A., Ricciolini R., Di Cocco M.E., Ramacci M.T., Angelucci L., et al. Aging brain: effect of acetyl-carnitine treatment on the rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy. Brain Res 1990, 526:108-112.
    • (1990) Brain Res , vol.526 , pp. 108-112
    • Aureli, T.1    Miccheli, A.2    Ricciolini, R.3    Di Cocco, M.E.4    Ramacci, M.T.5    Angelucci, L.6
  • 40
    • 0028347621 scopus 로고
    • Effect of acetyl-L-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat- study by 31P and 1H NMR spectroscopy
    • Aureli T, Miccheli A, Di Cocco ME, Ghirardi O, Giuliani A, Ramacci MT, et al. Effect of acetyl-L-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat- study by 31P and 1H NMR spectroscopy. Brain Res1994; 643: 92-99.
    • (1994) Brain Res , vol.643 , pp. 92-99
    • Aureli, T.1    Miccheli, A.2    Di Cocco, M.E.3    Ghirardi, O.4    Giuliani, A.5    Ramacci, M.T.6
  • 41
    • 0028874731 scopus 로고
    • Acetyl-L-carnitine attenuates neuronal damage gerbils transient forebrain ischemia only when given before insult
    • Shuaib A., Waqaar T., Wishart T., Kanthan R., Howlett W. Acetyl-L-carnitine attenuates neuronal damage gerbils transient forebrain ischemia only when given before insult. Neurochem Res 1995, 20:1021-1025.
    • (1995) Neurochem Res , vol.20 , pp. 1021-1025
    • Shuaib, A.1    Waqaar, T.2    Wishart, T.3    Kanthan, R.4    Howlett, W.5
  • 42
    • 0142241197 scopus 로고    scopus 로고
    • L-Carnitine reduces brain injury after hypoxia-ischemia in newborn rats
    • Wainwright M.S., Mannix M.K., Brown J., Stumpf D. L-Carnitine reduces brain injury after hypoxia-ischemia in newborn rats. Pediatr 2003, 54:688-695.
    • (2003) Pediatr , vol.54 , pp. 688-695
    • Wainwright, M.S.1    Mannix, M.K.2    Brown, J.3    Stumpf, D.4
  • 43
    • 32444431978 scopus 로고    scopus 로고
    • Neuroprotective effects of L-carnitine and vitamin E alone or in combination against ischemia-reperfusion injury in rats
    • Onem G, Aral E, Enli Y, Oguz EO, Coskun E, Aybek H, et al. Neuroprotective effects of L-carnitine and vitamin E alone or in combination against ischemia-reperfusion injury in rats. J Surg Res2006; 131:124-130.
    • (2006) J Surg Res , vol.131 , pp. 124-130
    • Onem, G.1    Aral, E.2    Enli, Y.3    Oguz, E.O.4    Coskun, E.5    Aybek, H.6
  • 44
    • 33644849567 scopus 로고    scopus 로고
    • Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats
    • Wainwright S.M., Kohli R., Whitington P.F., Chace D.H. Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats. Stroke 2006, 37:524-530.
    • (2006) Stroke , vol.37 , pp. 524-530
    • Wainwright, S.M.1    Kohli, R.2    Whitington, P.F.3    Chace, D.H.4
  • 45
  • 47
    • 84866294959 scopus 로고    scopus 로고
    • Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction
    • Rau T.F., Lu Q., Sharma S., Sun X., Leary G., Beckman M.L., et al. Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction. PLoS One 2012, 7:40881.
    • (2012) PLoS One , vol.7 , pp. 40881
    • Rau, T.F.1    Lu, Q.2    Sharma, S.3    Sun, X.4    Leary, G.5    Beckman, M.L.6
  • 48
    • 72949122642 scopus 로고    scopus 로고
    • Effect of L-carnitine on postischemic inhibition of protein synthesis in the rat brain
    • Burda1 J., Viadel M.H., Danielisova1 V., Nemethova1 M., Montoliu C., Felipo V. Effect of L-carnitine on postischemic inhibition of protein synthesis in the rat brain. Biophys 2009, 28:242-248.
    • (2009) Biophys , vol.28 , pp. 242-248
    • Burda1, J.1    Viadel, M.H.2    Danielisova1, V.3    Nemethova1, M.4    Montoliu, C.5    Felipo, V.6
  • 49
    • 0141756286 scopus 로고    scopus 로고
    • Inflammation, degeneration and regenerationin the injured spinal cord: insights from DNA microarrays
    • Bareyre F.M., Schwab M.E. Inflammation, degeneration and regenerationin the injured spinal cord: insights from DNA microarrays. Trends Neurosci 2003, 26:555-563.
    • (2003) Trends Neurosci , vol.26 , pp. 555-563
    • Bareyre, F.M.1    Schwab, M.E.2
  • 50
    • 79955071811 scopus 로고    scopus 로고
    • Targeting mitochondrial function for the treatment of acute spinal cord injury
    • McEwen M.L., Sullivan P.G., Rabchevsky A.G., Springer J.E. Targeting mitochondrial function for the treatment of acute spinal cord injury. Neurotherapeutics 2011, 8:168-179.
    • (2011) Neurotherapeutics , vol.8 , pp. 168-179
    • McEwen, M.L.1    Sullivan, P.G.2    Rabchevsky, A.G.3    Springer, J.E.4
  • 51
    • 63849186608 scopus 로고    scopus 로고
    • Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury
    • Hawryluk G.W., Rowland J., Kwon B.K., Fehlings M.G. Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury. Neurosurg Focus 2008, 25. E14.
    • (2008) Neurosurg Focus , vol.25
    • Hawryluk, G.W.1    Rowland, J.2    Kwon, B.K.3    Fehlings, M.G.4
  • 53
    • 0034992937 scopus 로고    scopus 로고
    • Neuroprotective effect of regional carnitine on spinal cord ischemia/reperfusion injury
    • Rahman A., Stuendagb B.U., Burma O., Ozercan I.H., Erol F.S. Neuroprotective effect of regional carnitine on spinal cord ischemia/reperfusion injury. Eur J Cardiothorac Surg 2001, 20:65-70.
    • (2001) Eur J Cardiothorac Surg , vol.20 , pp. 65-70
    • Rahman, A.1    Stuendagb, B.U.2    Burma, O.3    Ozercan, I.H.4    Erol, F.S.5
  • 55
    • 2542480017 scopus 로고    scopus 로고
    • Prevention of postischernic spinal cord injury by means of regional infusion of adenosine and L-carnitine dissolved in norrnotherrnic saline
    • Dargin O.T., Bakhroglu L., Ozkul Y., Ozardali I. Prevention of postischernic spinal cord injury by means of regional infusion of adenosine and L-carnitine dissolved in norrnotherrnic saline. Ann Vasc Surg 2004, 18:343-348.
    • (2004) Ann Vasc Surg , vol.18 , pp. 343-348
    • Dargin, O.T.1    Bakhroglu, L.2    Ozkul, Y.3    Ozardali, I.4
  • 56
    • 0347364740 scopus 로고    scopus 로고
    • Neuroprotective effects of FK-506, L-carnitine and azathioprine on spinal cord ischemia-reperfusion injury
    • Akgun S., Tekeli A., Kurtkaya O., Civelek A., Isbir S.C., Ak K., et al. Neuroprotective effects of FK-506, L-carnitine and azathioprine on spinal cord ischemia-reperfusion injury. Eur J Cardiothorac Surg 2004, 25:105-110.
    • (2004) Eur J Cardiothorac Surg , vol.25 , pp. 105-110
    • Akgun, S.1    Tekeli, A.2    Kurtkaya, O.3    Civelek, A.4    Isbir, S.C.5    Ak, K.6
  • 57
    • 77953294755 scopus 로고    scopus 로고
    • Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury
    • Patel S.P., Sulivan P.G., Lyttle T.S., Ravcheski A.V. Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. J Neurochem 2010, 114:291-301.
    • (2010) J Neurochem , vol.114 , pp. 291-301
    • Patel, S.P.1    Sulivan, P.G.2    Lyttle, T.S.3    Ravcheski, A.V.4
  • 58
    • 84864020782 scopus 로고    scopus 로고
    • Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats
    • Karaljia A., Novikova L.N., Kinghman P.J., Wiberg M., Novikov L.N. Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. Plos One 2012, 1086:7.
    • (2012) Plos One , vol.1086 , pp. 7
    • Karaljia, A.1    Novikova, L.N.2    Kinghman, P.J.3    Wiberg, M.4    Novikov, L.N.5
  • 59
    • 0030908696 scopus 로고    scopus 로고
    • Neuroprotective effects of acetyl-L-carnitine after stroke in rats
    • Lolic M.M., Fiskum G., Rosenthal R.E. Neuroprotective effects of acetyl-L-carnitine after stroke in rats. Ann Emerg Med 1997, 29:758-765.
    • (1997) Ann Emerg Med , vol.29 , pp. 758-765
    • Lolic, M.M.1    Fiskum, G.2    Rosenthal, R.E.3
  • 60
    • 0028352654 scopus 로고
    • Postischemic inhibition of cerebral cortex pyruvate dehydrogenase
    • Bogaert Y.E., Rosenthal R.E., Fiskum G. Postischemic inhibition of cerebral cortex pyruvate dehydrogenase. Free Rad Biol Med 1994, 16:811-820.
    • (1994) Free Rad Biol Med , vol.16 , pp. 811-820
    • Bogaert, Y.E.1    Rosenthal, R.E.2    Fiskum, G.3
  • 61
    • 0027216810 scopus 로고
    • Glycogen in astrocytes: possible function as lactate supply for neighboring cells
    • Dringen R., Gebhardt R., Hamprecht B. Glycogen in astrocytes: possible function as lactate supply for neighboring cells. Brain Res 1993, 623:208-214.
    • (1993) Brain Res , vol.623 , pp. 208-214
    • Dringen, R.1    Gebhardt, R.2    Hamprecht, B.3
  • 62
    • 0002188416 scopus 로고    scopus 로고
    • Acetyl-L-carnitine: metabolism and applications in clinical practice
    • Furlong J.H. Acetyl-L-carnitine: metabolism and applications in clinical practice. Altern Med Rev 1996, 1:85-93.
    • (1996) Altern Med Rev , vol.1 , pp. 85-93
    • Furlong, J.H.1
  • 63
    • 0028814185 scopus 로고
    • Effects of acetyl-L-carnitine treatment and stress exposure on the nerve growth factor receptor [p75NGFR] mRNA level in the central nervous system of aged rats
    • Foreman P.J., Perez-Polo J.R., Angelucci L., Ramacci M.T., Taglialatela G. Effects of acetyl-L-carnitine treatment and stress exposure on the nerve growth factor receptor [p75NGFR] mRNA level in the central nervous system of aged rats. Prog Neuropsycho Pharmacol Biol Psychiat 1995, 19:117-133.
    • (1995) Prog Neuropsycho Pharmacol Biol Psychiat , vol.19 , pp. 117-133
    • Foreman, P.J.1    Perez-Polo, J.R.2    Angelucci, L.3    Ramacci, M.T.4    Taglialatela, G.5
  • 64
    • 0029986949 scopus 로고    scopus 로고
    • Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding worcester rat
    • Sima A.A.F., Ristic H., Merry A., Kamijo M., Lattimer S.A., Stevens M.J., et al. Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding worcester rat. J Clin Invest 1996, 97:1900-1907.
    • (1996) J Clin Invest , vol.97 , pp. 1900-1907
    • Sima, A.A.F.1    Ristic, H.2    Merry, A.3    Kamijo, M.4    Lattimer, S.A.5    Stevens, M.J.6
  • 65
    • 33845933757 scopus 로고    scopus 로고
    • Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for alzheimer's disease
    • Abdul H.M., Butterfield D.A. Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for alzheimer's disease. Free Radic Biol Med 2007, 42:371-384.
    • (2007) Free Radic Biol Med , vol.42 , pp. 371-384
    • Abdul, H.M.1    Butterfield, D.A.2
  • 66
    • 0028887004 scopus 로고
    • Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock
    • Winter B.K., Fiskum G., Gallo L.L. Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock. Br J Cancer 1995, 72:1173-1179.
    • (1995) Br J Cancer , vol.72 , pp. 1173-1179
    • Winter, B.K.1    Fiskum, G.2    Gallo, L.L.3
  • 67
    • 0036891437 scopus 로고    scopus 로고
    • The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review
    • Blaisdell W. The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review. Cardiovasc Surg 2002, 10:620-630.
    • (2002) Cardiovasc Surg , vol.10 , pp. 620-630
    • Blaisdell, W.1
  • 69
    • 0028849885 scopus 로고
    • Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study
    • Brevetti G., Perna S., Sabbá C., Martone V.D., Condorelli M. Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study. J Am Cell Cardiol 1995, 26:1411-1416.
    • (1995) J Am Cell Cardiol , vol.26 , pp. 1411-1416
    • Brevetti, G.1    Perna, S.2    Sabbá, C.3    Martone, V.D.4    Condorelli, M.5
  • 70
    • 0035069062 scopus 로고    scopus 로고
    • Comparison of histopathologic effects of carnitine and ascorbic acid on reperfusion injury
    • Akar H., Sarac A., Konuralp C., Yildizc L., Kolbakir F. Comparison of histopathologic effects of carnitine and ascorbic acid on reperfusion injury. Eur J Cardiothorac Surg 2001, 19:500-506.
    • (2001) Eur J Cardiothorac Surg , vol.19 , pp. 500-506
    • Akar, H.1    Sarac, A.2    Konuralp, C.3    Yildizc, L.4    Kolbakir, F.5
  • 71
    • 0036217443 scopus 로고    scopus 로고
    • L-propionylcarnitine protects tissue from ischemic injury in an in vivo human ischemia-reperfusion model
    • Andreozzi G.M., Martini R., Cordova R.M., D'Eri A. L-propionylcarnitine protects tissue from ischemic injury in an in vivo human ischemia-reperfusion model. Clin Drug Investig 2002, 22:15-21.
    • (2002) Clin Drug Investig , vol.22 , pp. 15-21
    • Andreozzi, G.M.1    Martini, R.2    Cordova, R.M.3    D'Eri, A.4
  • 72
    • 77949770935 scopus 로고    scopus 로고
    • Glycine propionyl-L-carnitine modul lipid peroxidation nitric oxide hum subjects
    • Bloomer R.J., Tschume L.C., Smith W.A. Glycine propionyl-L-carnitine modul lipid peroxidation nitric oxide hum subjects. Int J Vitam Nutr Res 2009, 79:131-141.
    • (2009) Int J Vitam Nutr Res , vol.79 , pp. 131-141
    • Bloomer, R.J.1    Tschume, L.C.2    Smith, W.A.3
  • 73
    • 77953512874 scopus 로고    scopus 로고
    • Oxidative stress in response to forearm ischemia-reperfusion with and without carnitine administration
    • Bloomer R.J., Smith W.A., Fisher-Wellman K.H. Oxidative stress in response to forearm ischemia-reperfusion with and without carnitine administration. Int J Vitam Nutr Res 2010, 80:12-23.
    • (2010) Int J Vitam Nutr Res , vol.80 , pp. 12-23
    • Bloomer, R.J.1    Smith, W.A.2    Fisher-Wellman, K.H.3
  • 74
    • 84884575109 scopus 로고    scopus 로고
    • L-Carnitine pretreatment protects slow-twitch skeletal muscles in a rat model of ischemia-reperfusion injury
    • Demirel M., Kaya B., Cerkez C., Ertunc M., Sara Y. L-Carnitine pretreatment protects slow-twitch skeletal muscles in a rat model of ischemia-reperfusion injury. Vac Endovasc Surg 2013, 47:540-545.
    • (2013) Vac Endovasc Surg , vol.47 , pp. 540-545
    • Demirel, M.1    Kaya, B.2    Cerkez, C.3    Ertunc, M.4    Sara, Y.5
  • 75
    • 39149128229 scopus 로고    scopus 로고
    • Levopropionyl carnitine improves the effectiveness of supervised physical training onthe absolute claudicationdistance in patients with intermittent claudication
    • Andreozzi G.M., Leone A., Laudani R., Martin R., Deinit G., Cataldi V. Levopropionyl carnitine improves the effectiveness of supervised physical training onthe absolute claudicationdistance in patients with intermittent claudication. Angiology 2008, 59:84-89.
    • (2008) Angiology , vol.59 , pp. 84-89
    • Andreozzi, G.M.1    Leone, A.2    Laudani, R.3    Martin, R.4    Deinit, G.5    Cataldi, V.6
  • 76
    • 51749092435 scopus 로고    scopus 로고
    • L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats
    • Dutta A., Ray K., Singh V.K., Vats P., Singh S.N., Singh S.B. L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats. Exp Physiol 2008, 93:1139-1146.
    • (2008) Exp Physiol , vol.93 , pp. 1139-1146
    • Dutta, A.1    Ray, K.2    Singh, V.K.3    Vats, P.4    Singh, S.N.5    Singh, S.B.6
  • 77
    • 12744269437 scopus 로고    scopus 로고
    • Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions
    • Scarabelli T.M., Gottlieb R.A. Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions. Cell Death Differ 2004, 11:44-52.
    • (2004) Cell Death Differ , vol.11 , pp. 44-52
    • Scarabelli, T.M.1    Gottlieb, R.A.2
  • 78
    • 23944433387 scopus 로고    scopus 로고
    • Nitric oxide and skeletal muscle reperfusion injury: current controversies (research review)
    • Khanna A., Cowled P.A., Fitridge R.A. Nitric oxide and skeletal muscle reperfusion injury: current controversies (research review). J Surg Res 2005, 128:98-107.
    • (2005) J Surg Res , vol.128 , pp. 98-107
    • Khanna, A.1    Cowled, P.A.2    Fitridge, R.A.3


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