9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate

Nature Communications

Volumn 6, Issue , 2015, Pages

  Baumann, Anna Maria T ^a   Bakkers, Mark J G ^b   Buettner, Falk F R ^a   Hartmann, Maike ^a   Grove, Melanie ^a   Langereis, Martijn A ^b   De Groot, Raoul J ^b   Muhlenhoff, Martina ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; CYCLIC CMP; GANGLIOSIDE; N ACETYLNEURAMINIC ACID; SIALIC ACID; SIALOGLYCOPROTEIN; 9-O-ACETYL-N-ACETYLNEURAMINIC ACID; ACYLTRANSFERASE; ALPHA-N-ACETYLNEURAMINATE ALPHA-2,8-SIALYLTRANSFERASE; CASD1 PROTEIN, HUMAN; SIALIC ACID DERIVATIVE; SIALYLTRANSFERASE;

CATALYSIS; CYTOLOGY; ENZYME ACTIVITY; GENOME; HOST-PATHOGEN INTERACTION; MOLECULAR ANALYSIS;

9 O ACETYLATION; ACETYLATION; ANIMAL CELL; ARTICLE; CASD1 GENE; CATALYST; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CRISPR CAS SYSTEM; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE; GENE INACTIVATION; GENOME EDITING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LIQUID CHROMATOGRAPHY; NONHUMAN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; CATALYSIS; CELL LINE; CHO CELL LINE; CRICETULUS; DOG; GENETICS; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; MDCK CELL LINE; METABOLISM; MOUSE; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE; SF9 CELL LINE; SITE DIRECTED MUTAGENESIS; SPODOPTERA; TRANSGENIC ORGANISM; TUMOR CELL LINE;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; CATALYSIS; CATALYTIC DOMAIN; CELL LINE; CELL LINE, TUMOR; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETULUS; CRISPR-CAS SYSTEMS; DOGS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; IN VITRO TECHNIQUES; MADIN DARBY CANINE KIDNEY CELLS; MASS SPECTROMETRY; MICE; MUTAGENESIS, SITE-DIRECTED; ORGANISMS, GENETICALLY MODIFIED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE; SF9 CELLS; SIALIC ACIDS; SIALYLTRANSFERASES; SPODOPTERA;

EID: 84937054259     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8673     Document Type: Article

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