The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine

ACS Chemical Neuroscience

Volumn 6, Issue 7, 2015, Pages 1231-1240

  Zeeb, Fiona D ^a   Higgins, Guy A ^b,c   Fletcher, Paul J ^a,c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b InterVivo Solutions Inc   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Brain stimulation reward; intracranial self stimulation; lorcaserin; nicotine; reward; serotonin 2C receptor

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; LORCASERIN; NICOTINE; SODIUM CHLORIDE; 6-CHLORO-5-METHYL-1-((2-(2-METHYLPYRID-3-YLOXY)PYRID-5-YL)CARBAMOYL)INDOLINE; AMINOPYRIDINE DERIVATIVE; BENZAZEPINE DERIVATIVE; INDOLE DERIVATIVE; NICOTINIC AGENT; SEROTONIN 2 AGONIST; SEROTONIN 2 ANTAGONIST; SEROTONIN 2C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DOSE RESPONSE; DRUG EFFICACY; MALE; MEDIAL FOREBRAIN BUNDLE; MENTAL DISEASE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; REWARD; SELF STIMULATION; TOBACCO DEPENDENCE; ANIMAL; DRUG EFFECTS; LONG EVANS RAT; METABOLISM; PHYSIOLOGY;

RATTUS;

AMINOPYRIDINES; ANIMALS; BENZAZEPINES; DORSAL RAPHE NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; MALE; MEDIAL FOREBRAIN BUNDLE; NICOTINE; NICOTINIC AGONISTS; RATS, LONG-EVANS; RECEPTOR, SEROTONIN, 5-HT2C; REWARD; SELF STIMULATION; SEROTONIN 5-HT2 RECEPTOR AGONISTS; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS;

EID: 84937046151     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00017     Document Type: Article

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