PH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis

Journal of Controlled Release

Volumn 205, Issue , 2015, Pages 134-143

  Choi, Joung Woo ^a   Jung, Soo Jung ^a   Kasala, Dayananda ^a   Hwang, June Kyu ^a   Hu, Jun ^b   Bae, You Han ^b,c   Yun, Chae Ok ^a  

^a Hanyang University   (South Korea)

^b UNIVERSITY OF UTAH   (United States)

^c Utah Inha DDS and Advanced Theapeutics Research Center   (South Korea)

Author keywords

Cancer gene therapy; Hypoxia; Oncolytic adenovirus; pH sensitive polymers; Systemic administration; Tumor microenvironment

Indexed keywords

AMINO ACIDS; BLOCK COPOLYMERS; CELLS; CYTOLOGY; DISEASES; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENES; PH SENSORS; PLASTIC COATINGS; POLYETHYLENE GLYCOLS; POLYMERS; TISSUE; TOXICITY; TUMORS;

CANCER GENE THERAPY; HYPOXIA; ONCOLYTIC ADENOVIRUS; PH SENSITIVE POLYMERS; SYSTEMIC ADMINISTRATION; TUMOR MICROENVIRONMENT;

GENE THERAPY;

E1A PROTEIN; E1B PROTEIN; HISTIDINE; MACROGOL DERIVATIVE; MONOMETHOXYPOLYETHYLENE GLYCOL; ONCOLYTIC VIRUS; PEPTIDE; POLYHISTIDINE; POLYPHENYLALANINE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADENOVIRIDAE; ADVERSE EFFECTS; ANGIOGENESIS; ANIMAL; CELL HYPOXIA; CELL MOTION; CHEMISTRY; COMPARATIVE STUDY; DRUG SCREENING; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; MCF-7 CELL LINE; METABOLISM; MUTATION; NEOPLASMS; NUDE MOUSE; ONCOLYTIC VIROTHERAPY; PATHOGENICITY; PATHOLOGY; PH; PROCEDURES; SPRAGUE DAWLEY RAT; TIME FACTOR; TISSUE CULTURE TECHNIQUE; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR VOLUME; VIROLOGY;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; ADENOVIRUS E1B PROTEINS; ANIMALS; CELL HYPOXIA; CELL MOVEMENT; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; HEK293 CELLS; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNITY, INNATE; MCF-7 CELLS; MICE, NUDE; MUTATION; NEOPLASM INVASIVENESS; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; PEPTIDES; POLYETHYLENE GLYCOLS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TISSUE CULTURE TECHNIQUES; TRANSDUCTION, GENETIC; TUMOR BURDEN; TUMOR MICROENVIRONMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84937030384     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.01.005     Document Type: Article

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