Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus

Drug Research

Volumn 65, Issue 7, 2015, Pages 337-343

  Ghasemi, T ^a   Abnous, K ^b   Vahdati, F ^a   Mehri, S ^b   Razavi, B M ^c   Hosseinzadeh, H ^b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

antidepressant; BDNF; CREB; Crocus sativus; forced swimming test; P CREB; saffron; VGF; Western blot

Indexed keywords

BETA ACTIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CROCUS SATIVUS EXTRACT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMIPRAMINE; NEUROPEPTIDE; PHOSPHOPROTEIN; ANTIDEPRESSANT AGENT; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; MESSENGER RNA; PLANT EXTRACT; VGF PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; CROCUS SATIVUS; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; FORCED SWIM TEST; GENETIC TRANSCRIPTION; HIPPOCAMPUS; IMMOBILITY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CROCUS; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; PHOSPHORYLATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CROCUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HIPPOCAMPUS; IMIPRAMINE; MALE; NEUROPEPTIDES; PHOSPHORYLATION; PLANT EXTRACTS; RATS; RNA, MESSENGER;

EID: 84937023947     PISSN: 21949379     EISSN: 21949387     Source Type: Journal    
DOI: 10.1055/s-0034-1371876     Document Type: Article

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