Investigating the Role of the Post-transcriptional Gene Regulator MIR-24-3p in the Proliferation, Migration and Apoptosis of Human Arterial Smooth Muscle Cells in Arteriosclerosis Obliterans

Cellular Physiology and Biochemistry

Volumn 36, Issue 4, 2015, Pages 1359-1370

  Zhu, Xiao Feng ^a   Shan, Zhen ^a   Ma, Jie Yi ^a   Wang, Mian ^a   Zhang, Chun Xiang ^d   Liu, Rui Ming ^a,b,c   Wu, Wei Bin ^a   Shi, Ya Wei ^a   Li, Wen ^a,b,c   Wang, Shen Ming ^a,b,c  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangdong Engineering Laboratory for Diagnosis and Treatment of Vascular Disease   (China)

^c Vascular Surgical Disease Research Center of Guangdong Province   (China)

^d RUSH MEDICAL COLLEGE   (United States)

Author keywords

Arteriosclerosis obliterans; Atherosclerosis; C myc; Human arterial smooth muscle cells; MiRNA 24 3p; Peripheral arterial disease; Platelet derived growth factor receptor B

Indexed keywords

MICRORNA 143; MICRORNA 145; MICRORNA 24; MICRORNA 24 3P; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG; MICRORNA; MIRN24 MICRORNA, HUMAN; MYC PROTEIN; MYC PROTEIN, HUMAN;

3' UNTRANSLATED REGION; APOPTOSIS; ARTERY MUSCLE; ARTICLE; CELL COUNTING; CELL CULTURE; CLINICAL PRACTICE; COLORECTAL CANCER; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; IN SITU HYBRIDIZATION; LARYNX CARCINOMA; LUCIFERASE ASSAY; ONCOGENE C MYC; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; WESTERN BLOTTING; WOUND HEALING; CELL MOTION; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; SMOOTH MUSCLE CELL;

APOPTOSIS; ARTERIOSCLEROSIS OBLITERANS; BASE SEQUENCE; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MICRORNAS; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA;

EID: 84936984460     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430302     Document Type: Article

References (38)

1. Fuster V, Badimon L, Badimon JJ, Chesebro JH: The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 1992;326310-318.
2. Ross R, Glomset JA: The pathogenesis of atherosclerosis (first of two parts). N Engl J Med 1976;295:369-377.
3. Fowkes FG, Rudan D, Rudan I, Aboyans V, Denenberg JO, McDermott MM, Norman PE, Sampson UK, Williams LJ, Mensah GA, Criqui MH: Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: A systematic review and analysis. Lancet 2013;382:1329-1340.
4. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2095-2128.
5. Ohnishi H, Sawayama Y, Furusyo N, Maeda S, Tokunaga S, Hayashi J: Risk factors for and the prevalence of peripheral arterial disease and its relationship to carotid atherosclerosis: The Kyushu and Okinawa Population Study (KOPS). J Atheroscler Thromb 2010;17:751-758.
6. Nowygrod R, Egorova N, Greco G, Anderson P, Gelijns A, Moskowitz A, McKinsey J, Morrissey N, Kent KC: Trends, complications, and mortality in peripheral vascular surgery. J Vasc Surg 2006;43:205-216.
7. Ankle Brachial Index Collaboration, Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, Wautrecht JC, Kornitzer M, Newman AB, Cushman M, Sutton-Tyrrell K, Fowkes FG, Lee AJ, Price JF, d'Agostino RB: Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: A meta-analysis. JAMA 2008;300:197-208.
8. Kloosterman WP, Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell 2006;11:441-450.
9. Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z: Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet 2005;37:766-770.
10. Madrigal-Matute J, Rotllan N, Aranda JF, Fernández-Hernando C: MicroRNAs and atherosclerosis. Curr Atheroscler Rep 2013;15:322.
11. Hata A: Functions of microRNAs in cardiovascular biology and disease. Annu Rev Physiol 2013;75:69-93.
12. Zhao Y, Samal E, Srivastava D: Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 2005;436:214-220.
13. Wang M, Li W, Chang GQ, Ye CS, Ou JS, Li XX, Liu Y, Cheang TY, Huang XL, Wang SM: MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities. Arterioscler Thromb Vasc Biol 2011;31:2044-2053.
14. Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, Lu Q, Deitch EA, Huo Y, Delphin ES, Zhang C: MicroRNA-145, a novel smooth muscle cellphenotypic marker and modulator, controls vascular neointimal lesionformation. Circ Res 2009;105:158-166.
15. Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN: MicroRNAs MIR-143 and MIR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev 2009;23:2166-2178.
16. Liu X, Cheng Y, Zhang S, Lin Y, Yang J, Zhang C: A necessary role of MIR-221 and MIR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res 2009;104:476-487.
17. Mishra PJ, Song B, Mishra PJ, Wang Y, Humeniuk R, Banerjee D, Merlino G, Ju J, Bertino JR: MIR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism. PLOS ONE 2009;4:e8445.
18. G uo Y, Fu W, Chen H, Shang C, Zhong M: MIR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein. Oncol Rep 2012;27:1097-1103.
19. Xie Y, Tobin LA, Camps J, Wangsa D, Yang J, Rao M, Witasp E, Awad KS, Yoo N, Ried T, Kwong KF: MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells. Oncogene 2013;32:2442-2451.
20. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A: Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J 2010;29:559-573.
21. Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JT, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J: MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 2011;124:720-730.
22. Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D: miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med 2011;208:549-560.
23. Karina Di Gregoli, Nicholas Jenkins, Rebecca Salter, Stephen White, Andrew C Newby, Jason L Johnson. MicroRNA-24 regulates macrophage behavior and retards Atherosclerosis. Arterioscler Thromb Vasc Biol 2014;34:1990-2000.
24. Doran AC, Meller N, McNamara CA: Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol 2008;28:812-819.
25. Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB, Bartel DP: The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science 2005;310:1817-1821.
26. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG: MicroRNA MIR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood 2008;111:588-595.
27. Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J: MIR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell 2009;35:610-625.
28. Hart CE, Forstrom JW, Kelly JD, Seifert RA, Smith RA, Ross R, Murray MJ, Bowen-Pope DF: Two classes of PDGF receptor recognize different isoforms of PDGF. Science 1988;240:1529-1531.
29. Crosby JR, Seifert RA, Soriano P, Bowen-Pope DF: Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages. Nat Genet 1998;18:385-388.
30. Andrae J, Gallini R, Betsholtz C: Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008;22:1276-1312.
31. Boucher P, Liu P, Gotthardt M, Hiesberger T, Anderson RG, Herz J: Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low density lipoprotein receptor-related protein in caveolae. J Biol Chem 2002;27715507-15513.
32. Boucher P, Gotthardt M, Li WP, Anderson RG, Herz J: LRP: role in vascular wall integrity and protection from atherosclerosis. Science 2003;300:329-332.
33. Miano JM, Vlasic N, Tota RR, Stemerman MB: Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. A putative in vivo mechanism for autocrine growth. Arterioscler Thromb 1993;13:211-219.
34. Biro S, Fu YM, Yu ZX, Epstein SE: Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration. Proc Natl Acad Sci 1993;90:654-658.
35. Marie-Luce Vignais, Henry B Sadowski, Diane Watling, Neil C Rogers. Platelet-Derived Growth Factor Induces Phosphorylation of Multiple JAK Family Kinases and STAT Proteins. Mol Cell Biol 1996;1759-1769.
36. Ross R, Glomset J, Kariya B, Harker L: A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci 1974;71:1207-1210.
37. Heldin CH, Westermark B: Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999;79:1283-1316.
38. Armelin HA, Armelin MC, Kelly K, Stewart T, Leder P, Cochran BH, Stiles CD: Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature 1984;310:655-660.