The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 27, 2015, Pages 8367-8372

  Collins, Patrick L ^a   Kyle, Katherine E ^a   Egawa, Takeshi ^a   Shinkai, Yoichi ^b   Oltz, Eugene M ^a   Moran, John V ^c  

^a WASHINGTON UNIVERSITY   (United States)

^b RIKEN   (Japan)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Epigenetics; Histone methylation; Repression; Retroviruses; Transposable elements

Indexed keywords

HISTONE METHYLTRANSFERASE; PROTEIN SETDB1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; SETDB1 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CHROMATIN; CONTROLLED STUDY; DNA METHYLATION; ENDOGENOUS RETROVIRUS; EPIGENETIC REPRESSION; EXOGENOUS RETROVIRUS; GENOMIC INSTABILITY; HISTONE METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RETROVIRIDAE; SOMATIC CELL; TRANSCRIPTION INITIATION; VIRUS LATENCY; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CBA MOUSE; CELL CULTURE; DNA MICROARRAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; GENETICS; HOST PATHOGEN INTERACTION; KNOCKOUT MOUSE; LONG TERMINAL REPEAT; METABOLISM; METHYLATION; PHYSIOLOGY; PRE B LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; VIROLOGY; VIRUS ACTIVATION; WESTERN BLOTTING;

MUS;

ANIMALS; B-LYMPHOCYTES; BLOTTING, WESTERN; BONE MARROW CELLS; CELLS, CULTURED; DNA METHYLATION; ENDOGENOUS RETROVIRUSES; EPIGENESIS, GENETIC; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HOST-PATHOGEN INTERACTIONS; LYSINE; METHYLATION; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRECURSOR CELLS, B-LYMPHOID; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TERMINAL REPEAT SEQUENCES; VIRUS ACTIVATION;

EID: 84936889694     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1422187112     Document Type: Article

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