Serum metabolomics in rats after acute paraquat poisoning

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 7, 2015, Pages 1049-1053

  Wang, Zhiyi ^a   Ma, Jianshe ^a   Zhang, Meiling ^a   Wen, Congcong ^a   Huang, Xueli ^a   Sun, Fa ^a   Wang, Shuanghu ^b   Hu, Lufeng ^a   Lin, Guanyang ^a   Wang, Xianqin ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b LISHUI PEOPLE S HOSPITAL   (China)

Author keywords

GC MS; Metabolomics; Paraquat; Poisoning; Rat

Indexed keywords

BUTYRIC ACID; DECANOIC ACID; GALACTOSE; GLYCEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PALMITIC ACID; PARAQUAT; PROLINE; SERINE; STEARIC ACID; THREONINE; TYROSINE; VALINE; AMINO ACID; BIOLOGICAL MARKER; HERBICIDE;

ACUTE TOXICITY; AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE METABOLISM; CELL DAMAGE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; GLUCOSE METABOLISM; LIPID METABOLISM; LIPID PEROXIDATION; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; PARAQUAT POISONING; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SECRETION; RAT; SERUM; ANIMAL; BLOOD; DRUG EFFECTS; METABOLOME; SPRAGUE DAWLEY RAT;

AMINO ACIDS; ANIMALS; BIOMARKERS; GALACTOSE; HERBICIDES; LIPID METABOLISM; MALE; METABOLOME; METABOLOMICS; PARAQUAT; RATS, SPRAGUE-DAWLEY;

EID: 84936879821     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b15-00147     Document Type: Article

References (22)

1. Costa MD, de Freitas ML, Dalmolin L, Oliveira LP, Fleck MA, Pagliarini P, Acker C, Roman SS, Brandao R. Diphenyl diselenide prevents hepatic alterations induced by paraquat in rats. Environ. Toxicol. Pharmacol., 36, 750-758 (2013).
2. Bismuth C, Garnier R, Baud FJ, Muszynski J, Keyes C. Paraquat poisoning. An overview of the current status. Drug Saf., 5, 243-251 (1990).
3. Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br. J. Clin. Pharmacol., 72, 745-757 (2011).
4. Xia K, He X, Dai Q, Cheng WH, Qi X, Guo M, Luo Y, Huang K, Zhao C, Xu W. Discovery of systematic responses and potential biomarkers induced by ochratoxin A using metabolomics. Food Additives & Contaminants, Part A, Chemistry, Analysis, Control. Exposure & Risk Assessment, 31, 1904-1913 (2014).
5. Boudonck KJ, Mitchell MW, Nemet L, Keresztes L, Nyska A, Shinar D, Rosenstock M. Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol. Pathol., 37, 280-292 (2009).
6. Beger RD, Sun J, Schnackenberg LK. Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity. Toxicol. Appl. Pharmacol., 243, 154-166 (2010).
7. Zhang L, Ye Y, An Y, Tian Y, Wang Y, Tang H. Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices. J. Proteome Res., 10, 614-623 (2011).
8. Huang Q, Tan Y, Yin P, Ye G, Gao P, Lu X, Wang H, Xu G. Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. Cancer Res., 73, 4992-5002 (2013).
9. Chen CM, Lua AC. Lung toxicity of paraquat in the rat. J. Toxicol. Environ. Health A, 60, 477-487 (2000).
10. Zhang M, Deng M, Ma J, Wang X. An evaluation of acute hydrogen sulfide poisoning in rats through serum metabolomics based on gas chromatography-mass spectrometry. Chem. Pharm. Bull., 62, 505-507 (2014).
11. Gu Y, Lu C, Zha Q, Kong H, Lu X, Lu A, Xu G. Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry. Mol. Biosyst., 8, 1535-1543 (2012).
12. Patti GJ, Yanes O, Siuzdak G. Innovation: Metabolomics: the apogee of the omics trilogy. Nat. Rev. Mol. Cell Biol., 13, 263-269 (2012).
13. Monte AA, Heard KJ, Vasiliou V. Prediction of drug response and safety in clinical practice. J. Med. Toxicol., 8, 43-51 (2012).
14. Mamas M, Dunn WB, Neyses L, Goodacre R. The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Arch. Toxicol., 85, 5-17 (2011).
15. Kwon H, Park J, An Y, Sim J, Park S. A smartphone metabolomics platform and its application to the assessment of cisplatin-induced kidney toxicity. Anal. Chim. Acta, 845, 15-22 (2014).
16. Wang X, Zhang M, Ma J, Zhang Y, Hong G, Sun F, Lin G, Hu L. Metabolic changes in paraquat poisoned patients and support vector machine model of discrimination. Biol. Pharm. Bull., 38, 470-475 (2015).
17. Hong JH, Lee WC, Hsu YM, Liang HJ, Wan CH, Chien CL, Lin CY. Characterization of the biochemical effects of naphthalene on the mouse respiratory system using NMR-based metabolomics. Journal of Applied Toxicology, 34, 1379-1388 (2014).
18. Hunter JE, Zhang J, Kris-Etherton PM. Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review. Am. J. Clin. Nutr., 91, 46-63 (2010).
19. Kingsbury KJ, Paul S, Crossley A, Morgan DM. The fatty acid composition of human depot fat. Biochem. J., 78, 541-550 (1961).
20. Li G, Yuzhen L, Yi C, Xiaoxiang C, Wei Z, Changqing Z, Shuang Y. DNaseI protects against paraquat-induced acute lung injury and pulmonary fibrosis mediated by mitochondrial DNA. BioMed Research International, 2015, 386952 (2015).
21. Hirai K, Witschi H, Cote MG. Mitochondrial injury of pulmonary alveolar epithelial cells in acute paraquat intoxication. Exp. Mol. Pathol., 43, 242-252 (1985).
22. Hirai K, Ikeda K, Wang GY. Paraquat damage of rat liver mitochondria by superoxide production depends on extramitochondrial NADH. Toxicology, 72, 1-16 (1992).