메뉴 건너뛰기




Volumn 9, Issue , 2015, Pages 3405-3412

Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: A randomized controlled trial

Author keywords

Adiposity; Anti inflammatory; Diabetes; Hypertension; Obesity; Vitamin C

Indexed keywords

ASCORBIC ACID; C REACTIVE PROTEIN; GLUCOSE; INTERLEUKIN 6; TRIACYLGLYCEROL; ANTIINFECTIVE AGENT; AUTACOID; BIOLOGICAL MARKER; CHOLESTEROL; GLUCOSE BLOOD LEVEL; IL6 PROTEIN, HUMAN;

EID: 84936866559     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S83144     Document Type: Article
Times cited : (147)

References (40)
  • 1
    • 23944482400 scopus 로고    scopus 로고
    • Regulation of vitamin C transport
    • Wilson JX. Regulation of vitamin C transport. Annu Rev Nutr. 2005;25:105–125.
    • (2005) Annu Rev Nutr , vol.25 , pp. 105-125
    • Wilson, J.X.1
  • 2
    • 43449119024 scopus 로고    scopus 로고
    • Effect of vitamin C supplement on glycosylated hemoglobin in patients with type 2 diabetes
    • Afkhami-Ardekani M, Vahidi AR, Borjian L, Borjian L. Effect of vitamin C supplement on glycosylated hemoglobin in patients with type 2 diabetes. J Shah Sad Univ. 2003;10:15–18.
    • (2003) J Shah Sad Univ , vol.10 , pp. 15-18
    • Afkhami-Ardekani, M.1    Vahidi, A.R.2    Borjian, L.3    Borjian, L.4
  • 3
    • 33947405296 scopus 로고    scopus 로고
    • Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients
    • Plantinga Y, Ghiadoni L, Magagna A, et al. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens. 2007;20(4):392–397.
    • (2007) Am J Hypertens , vol.20 , Issue.4 , pp. 392-397
    • Plantinga, Y.1    Ghiadoni, L.2    Magagna, A.3
  • 4
    • 0037465430 scopus 로고    scopus 로고
    • Antioxidant Supplementation in Atherosclerosis Prevention Study. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study
    • Salonen RM, Nyyssönen K, Kaikkonen J, et al; Antioxidant Supplementation in Atherosclerosis Prevention Study. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation. 2003;107(7):947–953.
    • (2003) Circulation , vol.107 , Issue.7 , pp. 947-953
    • Salonen, R.M.1    Nyyssönen, K.2    Kaikkonen, J.3
  • 5
    • 38149104641 scopus 로고    scopus 로고
    • Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study
    • Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw KT. Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study. Am J Clin Nutr. 2008;87(1):64–69.
    • (2008) Am J Clin Nutr , vol.87 , Issue.1 , pp. 64-69
    • Myint, P.K.1    Luben, R.N.2    Welch, A.A.3    Bingham, S.A.4    Wareham, N.J.5    Khaw, K.T.6
  • 6
    • 0033547645 scopus 로고    scopus 로고
    • Treatment of hypertension with ascorbic acid
    • Duffy SJ, Gokce N, Holbrook M, et al. Treatment of hypertension with ascorbic acid. Lancet. 1999;354(9195):2048–2049.
    • (1999) Lancet , vol.354 , Issue.9195 , pp. 2048-2049
    • Duffy, S.J.1    Gokce, N.2    Holbrook, M.3
  • 7
    • 34249801211 scopus 로고    scopus 로고
    • Long-term effects of oral vitamin C supplementation on the endothelial dysfunction in the iris microvessels of diabetic rats
    • Jariyapongskul A, Rungjaroen T, Kasetsuwan N, Patumraj S, Seki J, Niimi H. Long-term effects of oral vitamin C supplementation on the endothelial dysfunction in the iris microvessels of diabetic rats. Microvasc Res. 2007;74(1):32–38.
    • (2007) Microvasc Res , vol.74 , Issue.1 , pp. 32-38
    • Jariyapongskul, A.1    Rungjaroen, T.2    Kasetsuwan, N.3    Patumraj, S.4    Seki, J.5    Niimi, H.6
  • 8
    • 84936858825 scopus 로고    scopus 로고
    • Vitamin C may have similar beneficial effects to Gemfibrozil on serum high-density lipoprotein-cholesterol in type 2 diabetic patients
    • Siavash M, Amini M. Vitamin C may have similar beneficial effects to Gemfibrozil on serum high-density lipoprotein-cholesterol in type 2 diabetic patients. J Res Pharm Pract. 2014;3(3):77–82.
    • (2014) J Res Pharm Pract , vol.3 , Issue.3 , pp. 77-82
    • Siavash, M.1    Amini, M.2
  • 9
    • 84885076016 scopus 로고    scopus 로고
    • Comparative study of vitamin C on serum lipid profile in healthy male and female human subjects
    • Gaur GS, Dixit AK. Comparative study of vitamin C on serum lipid profile in healthy male and female human subjects. J Sci Res. 2012; 4(3):775–781.
    • (2012) J Sci Res , vol.4 , Issue.3 , pp. 775-781
    • Gaur, G.S.1    Dixit, A.K.2
  • 10
    • 84892785387 scopus 로고    scopus 로고
    • Effect of antioxidant vitamin supplementation on endothelial function in type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials
    • Montero D, Walther G, Stehouwer A, Houben A, Beckman J, Vinet A. Effect of antioxidant vitamin supplementation on endothelial function in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2014;15(2):107–116.
    • (2014) Obes Rev , vol.15 , Issue.2 , pp. 107-116
    • Montero, D.1    Walther, G.2    Stehouwer, A.3    Houben, A.4    Beckman, J.5    Vinet, A.6
  • 11
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454(7203):428–435.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 428-435
    • Medzhitov, R.1
  • 12
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • Boura-Halfon S, Zick Y. Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol. 2009;296(4):E581–E591.
    • (2009) Am J Physiol , vol.296 , Issue.4 , pp. E581-E591
    • Boura-Halfon, S.1    Zick, Y.2
  • 13
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87–91.
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 15
    • 58149511929 scopus 로고    scopus 로고
    • Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists
    • Zhang S, Liu Q, Wang J, Harnish DC. Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists. Biochem Biophys Res Commun. 2009;379(2):476–479.
    • (2009) Biochem Biophys Res Commun , vol.379 , Issue.2 , pp. 476-479
    • Zhang, S.1    Liu, Q.2    Wang, J.3    Harnish, D.C.4
  • 16
    • 0141627702 scopus 로고    scopus 로고
    • C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults
    • Ford ES, Liu S, Mannino DM, Giles WH, Smith SJ. C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults. Eur J Clin Nutr. 2003;57(9):1157–1163.
    • (2003) Eur J Clin Nutr , vol.57 , Issue.9 , pp. 1157-1163
    • Ford, E.S.1    Liu, S.2    Mannino, D.M.3    Giles, W.H.4    Smith, S.J.5
  • 17
    • 84881427604 scopus 로고    scopus 로고
    • Clinical experience with intravenous administration of ascorbic acid: Achievable levels in blood for different states of inflammation and disease in cancer patients
    • Mikirova N, Casciari J, Riordan N, Hunninghake R. Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients. J Transl Med. 2013;11:191.
    • (2013) J Transl Med , vol.11
    • Mikirova, N.1    Casciari, J.2    Riordan, N.3    Hunninghake, R.4
  • 18
    • 84866613772 scopus 로고    scopus 로고
    • Ascorbic acid: Chemistry, biology and the treatment of cancer
    • Du J, Cullen JJ, Buettner GR. Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta. 2012;1826(2):443–457.
    • (2012) Biochim Biophys Acta , vol.1826 , Issue.2 , pp. 443-457
    • Du, J.1    Cullen, J.J.2    Buettner, G.R.3
  • 19
    • 84867848490 scopus 로고    scopus 로고
    • Vitamin C, gastritis, and gastric disease: A historical review and update
    • Aditi A, Graham DY. Vitamin C, gastritis, and gastric disease: a historical review and update. Dig Dis Sci. 2012;57(10):2504–2515.
    • (2012) Dig Dis Sci , vol.57 , Issue.10 , pp. 2504-2515
    • Aditi, A.1    Graham, D.Y.2
  • 20
    • 84872203825 scopus 로고    scopus 로고
    • Influence of mediterranean diet on asthma symptoms, lung function, and systemic inflammation: A randomized controlled trial
    • Sexton P, Black P, Metcalf P, et al. Influence of mediterranean diet on asthma symptoms, lung function, and systemic inflammation: a randomized controlled trial. J Asthma. 2013;50(1):75–81.
    • (2013) J Asthma , vol.50 , Issue.1 , pp. 75-81
    • Sexton, P.1    Black, P.2    Metcalf, P.3
  • 21
    • 33645649606 scopus 로고    scopus 로고
    • Is vitamin C an antiinflammatory agent?
    • Jialal I, Singh U. Is vitamin C an antiinflammatory agent? Am J Clin Nutr. 2006;83(3):525–526.
    • (2006) Am J Clin Nutr , vol.83 , Issue.3 , pp. 525-526
    • Jialal, I.1    Singh, U.2
  • 22
    • 77954908117 scopus 로고    scopus 로고
    • Geneva: WHO, Accessed May 26, 2015
    • World Health Organization (WHO) Department of Non-communicable Diseases. Global Physical Activity Questionnaire: Analysis Guide. Geneva: WHO; 2002. Available from: http://www.who.int/chp/steps/resources/GPAQ_Analysis_Guide.pdf. Accessed May 26, 2015.
    • (2002) Global Physical Activity Questionnaire: Analysis Guide
  • 23
    • 1642528856 scopus 로고    scopus 로고
    • Plasma C-reactive protein concentrations in active and passive smokers: Influence of antioxidant supplementation
    • Block G, Jensen C, Dietrich M, Norkus E, Hudes M, Packer L. Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. J Am Coll Nutr. 2004;23(2):141–147.
    • (2004) J am Coll Nutr , vol.23 , Issue.2 , pp. 141-147
    • Block, G.1    Jensen, C.2    Dietrich, M.3    Norkus, E.4    Hudes, M.5    Packer, L.6
  • 24
    • 84864748358 scopus 로고    scopus 로고
    • Atlanta, GA: US Department of Health and Human Services CDC
    • Centers for Disease Control and Prevention (CDC). Behavioral Risk Factor Surveillance System Survey Questionnaire. Atlanta, GA: US Department of Health and Human Services CDC; 2011.
    • (2011) Behavioral Risk Factor Surveillance System Survey Questionnaire
  • 25
    • 0004318660 scopus 로고    scopus 로고
    • WHO Technical Report Series 894. Geneva: WHO, Accessed May 26, 2015
    • WHO. Obesity: Preventing and Managing the Global Epidemic: Report of a WHO Consultation. WHO Technical Report Series 894. Geneva: WHO; 2000. Available from: http://www.who.int/nutrition/publications/obesity/WHO_TRS_894/en/. Accessed May 26, 2015.
    • (2000) Obesity: Preventing and Managing the Global Epidemic: Report of a WHO Consultation
  • 27
    • 0036566620 scopus 로고    scopus 로고
    • Vitamin C inhibits granulocyte macrophage-colony-stimulating factors-induced signaling pathway
    • Cárcamo JM, Bórquez-Ojeda O, Golde DW. Vitamin C inhibits granulocyte macrophage-colony-stimulating factors-induced signaling pathway. Blood. 2002;99(9):3205–3212.
    • (2002) Blood , vol.99 , Issue.9 , pp. 3205-3212
    • Cárcamo, J.M.1    Bórquez-Ojeda, O.2    Golde, D.W.3
  • 28
    • 2442530445 scopus 로고    scopus 로고
    • Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: Role of nuclear factor-kappa B
    • Choi JS, Choi YJ, Park SH, Kang JS, Kang YH. Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B. J Nutr. 2004;134(5):1013–1019.
    • (2004) J Nutr , vol.134 , Issue.5 , pp. 1013-1019
    • Choi, J.S.1    Choi, Y.J.2    Park, S.H.3    Kang, J.S.4    Kang, Y.H.5
  • 29
    • 84863900611 scopus 로고    scopus 로고
    • Mitigation of inflammation with foods
    • Wu X, Schauss AG. Mitigation of inflammation with foods. J Agric Food Chem. 2012;60(27):6703–6717.
    • (2012) J Agric Food Chem , vol.60 , Issue.27 , pp. 6703-6717
    • Wu, X.1    Schauss, A.G.2
  • 30
    • 84899532876 scopus 로고    scopus 로고
    • Effects of Vitamin C or E on the Pro-inflammatory Cytokines, Heat Shock Protein 70 and Antioxidant Status in Broiler Chicks under Summer Conditions
    • Jang IS, Ko YH, Moon YS, Sohn SH. Effects of Vitamin C or E on the Pro-inflammatory Cytokines, Heat Shock Protein 70 and Antioxidant Status in Broiler Chicks under Summer Conditions. Asian-Australas J Anim Sci. 2014;27(5):749–756.
    • (2014) Asian-Australas J Anim Sci , vol.27 , Issue.5 , pp. 749-756
    • Jang, I.S.1    Ko, Y.H.2    Moon, Y.S.3    Sohn, S.H.4
  • 31
    • 84895160693 scopus 로고    scopus 로고
    • Consumption of mixed fruit-juice drink and vitamin C reduces postprandial stress induced by a high fat meal in healthy overweight subjects
    • Peluso I, Villano D, Roberts S, et al. Consumption of mixed fruit-juice drink and vitamin C reduces postprandial stress induced by a high fat meal in healthy overweight subjects. Curr Pharm Des. 2014;20(6): 1020–1024.
    • (2014) Curr Pharm Des , vol.20 , Issue.6 , pp. 1020-1024
    • Peluso, I.1    Villano, D.2    Roberts, S.3
  • 32
    • 84887339818 scopus 로고    scopus 로고
    • Cross-over study of influence of oral vitamin C supplementation on inflammatory status in maintenance hemodialysis patients
    • Zhang KY, Li YH, Cheng XY, et al. Cross-over study of influence of oral vitamin C supplementation on inflammatory status in maintenance hemodialysis patients. BMC Nephrol. 2013;14:252.
    • (2013) BMC Nephrol , vol.14
    • Zhang, K.Y.1    Li, Y.H.2    Cheng, X.Y.3
  • 33
    • 57449100455 scopus 로고    scopus 로고
    • Vitamin C treatment reduces elevated C-reactive protein
    • Block G, Jensen C, Dalvi T, et al. Vitamin C treatment reduces elevated C-reactive protein. Free Radic Biol Med. 2009;46(1):70–77.
    • (2009) Free Radic Biol Med , vol.46 , Issue.1 , pp. 70-77
    • Block, G.1    Jensen, C.2    Dalvi, T.3
  • 35
    • 33645635277 scopus 로고    scopus 로고
    • Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis
    • Wannamethee SG, Lowe G, Rumley A, Bruckdorfer KR, Whincup PH. Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis. Am J Clin Nutr. 2006;83(3):567–574; quiz 726–727.
    • (2006) Am J Clin Nutr , vol.83 , Issue.3 , pp. 567-574
    • Wannamethee, S.G.1    Lowe, G.2    Rumley, A.3    Bruckdorfer, K.R.4    Whincup, P.H.5
  • 36
    • 84899780938 scopus 로고    scopus 로고
    • Vitamin C supplementation does not influence plasma and blood mononuclear cell IL-6 and IL-10 levels after exercise
    • Aguiló A, Monjo M, Moreno C, Martinez P, Martínez S, Tauler P. Vitamin C supplementation does not influence plasma and blood mononuclear cell IL-6 and IL-10 levels after exercise. J Sports Sci. 2014;32(7):1659–1669.
    • (2014) J Sports Sci , vol.32 , Issue.7 , pp. 1659-1669
    • Aguiló, A.1    Monjo, M.2    Moreno, C.3    Martinez, P.4    Martínez, S.5    Tauler, P.6
  • 37
    • 84881295343 scopus 로고    scopus 로고
    • Akhondzadeh S. Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: A randomized double-blind placebo-controlled study
    • Khajehnasiri F, Mortazavi SB, Allameh A, Akhondzadeh S. Effect of omega-3 and ascorbic acid on inflammation markers in depressed shift workers in Shahid Tondgoyan Oil Refinery, Iran: a randomized double-blind placebo-controlled study. J Clin Biochem Nutr. 2013;53(1):36–40.
    • (2013) J Clin Biochem Nutr , vol.53 , Issue.1 , pp. 36-40
    • Khajehnasiri, F.1    Mortazavi, S.B.2    Allameh, A.3
  • 38
    • 43049169029 scopus 로고    scopus 로고
    • Effect of vitamin C on blood glucose, serum lipids and serum insulin in type 2 diabetes patients
    • Afkhami-Ardekani M, Shojaoddiny-Ardekani A. Effect of vitamin C on blood glucose, serum lipids and serum insulin in type 2 diabetes patients. Indian J Med Res. 2006;126:471–474.
    • (2006) Indian J Med Res , vol.126 , pp. 471-474
    • Afkhami-Ardekani, M.1    Shojaoddiny-Ardekani, A.2
  • 39
    • 0034131346 scopus 로고    scopus 로고
    • Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer – Norfolk (EPIC-Norfolk) study: A population-based study
    • Sargeant LA, Wareham NJ, Bingham S, et al. Vitamin C and hyperglycemia in the European Prospective Investigation into Cancer – Norfolk (EPIC-Norfolk) study: a population-based study. Diabetes Care. 2000;23(6):726–732.
    • (2000) Diabetes Care , vol.23 , Issue.6 , pp. 726-732
    • Sargeant, L.A.1    Wareham, N.J.2    Bingham, S.3
  • 40
    • 84855593860 scopus 로고    scopus 로고
    • Supplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: A randomized, double-blind study
    • Dakhale GN, Chaudhari HV, Shrivastava M. Supplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: a randomized, double-blind study. Adv Pharmacol Sci. 2011;2011:195271.
    • (2011) Adv Pharmacol Sci , vol.2011
    • Dakhale, G.N.1    Chaudhari, H.V.2    Shrivastava, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.