Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): Overlooked biochemical factors that could influence PRP treatment

British Journal of Sports Medicine

Volumn 49, Issue 14, 2015, Pages 957-960

  Hamilton, Bruce ^a   Tol, Johannes L ^b   Knez, Wade ^b   Chalabi, Hakim ^b  

^a Auckland University of Technology High Performance Sport New Zealand   (New Zealand)

^b ASPETAR ORTHOPAEDIC AND SPORTS MEDICINE HOSPITAL   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHLORIDE; HEMATOLOGIC AGENT; PLATELET DERIVED GROWTH FACTOR; PLATELET-DERIVED GROWTH FACTOR AB; SCATTER FACTOR; SIGNAL PEPTIDE; SOMATOMEDIN C; VASCULOTROPIN A;

ADULT; CHEMISTRY; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; HUMAN; MALE; METABOLISM; NORMAL HUMAN; PHYSIOLOGY; THROMBOCYTE ACTIVATION; THROMBOCYTE RICH PLASMA;

ADULT; CALCIUM CHLORIDE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXERCISE; HEALTHY VOLUNTEERS; HEMATOLOGIC AGENTS; HEPATOCYTE GROWTH FACTOR; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PLATELET ACTIVATION; PLATELET-DERIVED GROWTH FACTOR; PLATELET-RICH PLASMA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84936864044     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsports-2012-091916     Document Type: Article

References (37)

1. Sheth U, Simunovic N, Klein G, et al. Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis. J Bone Joint Surg 2012;94:298-307.
2. Gosens T, Peerbooms JC, van Laar W, et al. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind reandomized controlled trial with 2-year follow-up. Am J Sports Med 2011;39:1200-8.
3. Thanasas C, Papadimitriou G, Charalambidis C, et al. Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: a randomized controlled clinical trial. Am J Sports Med 2011;39:2130-4.
4. de Vos R, Weir A, van Schie H, et al. Platelet-rich plasma injection for chronic Achilles tendinopathy; a randomized controlled trial. JAMA 2010;303:144-9.
5. Castricini R, Longo U, De Benedetto M, et al. Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial. Am J Sports Med 2010;39:258-65.
6. Peerbooms JC, Sluimer J, Bruijn DJ, et al. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med 2010;38:255-62.
7. Creaney L. Platelet-rich plasma and the biological complexity of tissue regeneration. Br J Sports Med 2011;45:611.
8. Hamilton B, Best TM. Platelet-enriched plasma and muscle strain injuries: challenges imposed by the burden of proof. Clin J Sport Med 2011;21:31-6.
9. Harrison S, Vavken P, Kevy S, et al. Platelet activation by collagen provides sustained release of anabolic cytokines. Am J Sports Med 2011;39:729-34.
10. Italiano J, Battinelli E. Selective sorting of alpha-granule proteins. J Thromb Haemost 2009;7:173-6.
11. Italiano J, Richardson J, Patel-Hett S, et al. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008;111:1227-33.
12. Andrews R, Gardiner E, Asazuma N, et al. A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI. J Biol Chem 2001;276:28092-7.
13. Rendu F, Brohard-Bohn F. The platelet release reaction: granules' constituents, secretion and functions. Platelets 2001;12:261-73.
14. Roberts D, McNicol A, Bose R. Mechanism of collagen activation in human platelets. J Biol Chem 2004;279:19421-30.
15. Heijnen H, Schiel A, Fijnheer R, et al. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 1999;94:3791-9.
16. Holme P, Orvim U, Hamers M, et al. Shear-induced platelet activation and platelet microparticle formation at blood flow conditions as in arteries with a severe stenosis. Arterioscler Thromb Vasc Biol 1997;17:646-53.
17. Anitua E, Sanchez A, Nurden A, et al. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol 2006;24:227-34.
18. Anitua E, Sanchez E, Orive G, et al. Therapeutic applications of the preparation rich in growth factors (PRGF). Recent Adv Biomater Res 2008:141-53.
19. Anitua E, Sanchez M, Orive G, et al. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials 2007;28:4551-60.
20. Everts P, Hoffmann J, Weibrich G, et al. Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transf Med 2006;16:363-8.
21. Everts P, Mahoney C, Hoffmann J, et al. Platelet-rich plasma preparation using three devices: Implications for platelet activation and platelet growth factor release. Growth Factors 2006;24:165-71.
22. Roussy Y, Duchesne M-P, Gagnon G. Activation of human platelet-rich plasmas: effect on growth factors release, cell division and in vivo bone formation. Clin Oral Implants Res 2007;18:639-48.
23. Zimmermann R, Jakubietz R, Jakubietz M, et al. Different preparation methods to obtain platelet components as a source of growth factors for local application. Transfusion 2001;41:1217-24.
24. Zimmermann R, Arnold D, Strasser E, et al. Sample preparation technique and white cell content influence the detectable levels of growth factors in platelet concentrates. Vox Sang 2003;85:283-9.
25. Chen Y-U, Chen J-K, Wang J-S. Strenuous exercise promotes shear-induced thrombin generation by increasing the shedding of procoagulant microparticles from platelets. Thromb Haemost 2010;104:293-301.
26. Legge B, Beanister E. The Astrand-Rhyming nomogram revisited. J Appl Physiol 1986;61:1203-9.
27. Astrand PO, Ryhming I. A Nomogram for calculation of aerobic capacity from pulse rate during submaximal work. J Appl Physiol 1954;7:218-21.
28. Castillo T, Pouliot M, Kim HL, et al. Comparison of growth factor and platelet concentration from commerscial platelet-rich plasma separation systems. Am J Sports Med 2011;39:266-71.
29. Hamilton B, Knez W, Eirale C, et al. Platelet enriched plasma for acute muscle injury. Acta Orthop Belg 2010;76:443-8.
30. Weibrich G, Hansen T, Kleis W, et al. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone 2004;34:665-71.
31. Marx R. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent 2001;10:225-8.
32. Marx R. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Res 2004;62:489-96.
33. Lopez-Vidriero E, Goulding K, Simon D, et al. The use of platelt-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. J Arthroscop Rel Surg 2010;26:269-78.
34. Liu Y, Kalen A, Risto O, et al. Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent. Wound Repair and Regen 2002;10:336-40.
35. Chan B, Fu C, Qin L, et al. Supplementation-time dependence of growth factors in promoting tendon healing. Clin Orthop Relat Res 2006;448:240-7.
36. Hildebrand K, Woo S, Smith DJ, et al. The effects of platelet-derived growth factor-B on healing of the rabbit medial collateral ligament. An in vivo study. Am J Sports Med 1998;26:549-54.
37. Eppley B, Woodell J, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 2004;114:1502-8.