Synthesis of α-methylene-β-lactams via PPh3-catalyzed umpolung cyclization of propiolamides

Journal of Organic Chemistry

Volumn 80, Issue 1, 2015, Pages 628-633

  Zhu, Lin ^a   Xiong, Yan ^b   Li, Chaozhong ^a,b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CATALYSIS; KETONES;

BETA-LACTAMS; FACILE SYNTHESIS; HIGH YIELD; REFLUXING ETHANOLS; TRIPHENYL PHOSPHINES; UMPOLUNG;

CYCLIZATION;

ALCOHOL; BETA LACTAM DERIVATIVE; CARBENE; DIETHYL 2 (N BENZYLPROPIOLAMIDO)MALONATE; ETHYL 1 (4 METHYLBENZYL) 3 METHYLENE 4 OXOAZETIDINE 2 CARBOXYLATE; ETHYL 1 (TERT BUTYL) 3 METHYLENE 4 OXOAZETIDINE 2 CARBOXYLATE; ETHYL 1 ISOBUTYL 3 METHYLENE 4 OXOAZETIDINE 2 CARBOXYLATE; ETHYL 2 (N BENZYLPROPIOLAMIDO)ACETATE; ETHYL 2 (N BENZYLPROPIOLAMIDO)PROPANOATE; ETHYL 2 (N HENYLPROPIOLAMIDO)ACETATE; ETHYL 2 (N ISOBUTYLPROPIOLAMIDO)ACETATE; ETHYL 2 [N (1 PHENYLETHYL)PROPIOLAMIDO]ACETATE; ETHYL 2 [N (4 METHOXYBENZYL)PROPIOLAMIDO]ACETATE; ETHYL 2 [N (4 METHYLBENZYL)PROPIOLAMIDO]ACETATE; ETHYL 2 [N (TERT BUTYL)PROPIOLAMIDO]ACETATE; ETHYL 3 METHYLENE 4 OXO 1 PHENYLAZETIDINE 2 CARBOXYLATE; ETHYL N [4 (TRIFLUOROMETHYL)BENZYL)PROPIOLAMIDO]ACETATE; IODOACETIC ACID; KETONE DERIVATIVE; N (2 OXO 2 PHENYLETHYL) N (4 TOLYL)PROPIOLAMIDE; N (2 OXO 2 PHENYLETHYL) N PHENYLPROPIOLAMIDE; N (4 CHLOROPHENYL) N (2 OXO 2 PHENYLETHYL)PROPIOLAMIDE; N (4 CHLOROPHENYL) N (2 OXOPROPYL)PROPIOLAMIDE; N (4 CHLOROPHENYL) N [2 (4 CHLOROPHENYL) 2 OXOETHYL]PROPIOLAMIDE; N (4 CHLOROPHENYL) N [2 (4 METHOXYPHENYL) 2 OXOETHYL]PROPIOLAMIDE; N (4 METHOXYPHENYL) N (2 OXO 2 PHENYLETHYL)PROPIOLAMIDE; N (CYANOMETHYL) N ISOBUTYLPROPIOLAMIDE; N BENZYL N (2 OXOCYCLOHEXYL)PROPIOLAMIDE; TERT BUTYL 2 (N BENZYLPROPIOLAMIDO)ACETATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; AMIDE; CYCLOPROPANE DERIVATIVE; LACTAM; PHOSPHINE DERIVATIVE;

ARTICLE; CATALYSIS; CYCLIZATION; DRUG SYNTHESIS; SUBSTITUTION REACTION; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

AMIDES; CATALYSIS; CYCLIZATION; CYCLOPROPANES; LACTAMS; MOLECULAR STRUCTURE; PHOSPHINES;

EID: 84936855744     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo502265a     Document Type: Article

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