Factor VIII interacts with the endocytic receptor low-density lipoprotein receptor-related protein 1 via an extended surface comprising "hot-spot" lysine residues

Journal of Biological Chemistry

Volumn 290, Issue 27, 2015, Pages 16463-16476

  Van Den Biggelaar, Maartje ^a   Madsen, Jesper J ^b   Faber, Johan H ^b   Zuurveld, Marleen G ^a   Van Der Zwaan, Carmen ^a   Olsen, Ole H ^b   Stennicke, Henning R ^b   Mertens, Koen ^a,c   Meijer, Alexander B ^a,c  

^a CENTRAL LABORATORY   (Netherlands)

^b NOVO NORDISK A S   (Denmark)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; LIGANDS; LIPOPROTEINS; PROTEINS;

EXTENDED SURFACES; FACTOR VIII; HOT SPOT; LDL RECEPTORS; LOW DENSITY LIPOPROTEIN RECEPTORS; LYSINE RESIDUES; PROTEIN LIGANDS;

AMINO ACIDS;

ALANINE; ARGININE; BLOOD CLOTTING FACTOR 8; GLUTAMIC ACID; HETERODIMER; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LYSINE; LOW DENSITY LIPOPROTEIN; LRP1 PROTEIN, HUMAN; PROTEIN BINDING;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; LIGAND BINDING; MASS SPECTROMETRY; MUTAGENESIS; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SURFACE PLASMON RESONANCE; AMINO ACID SEQUENCE; CHEMISTRY; ENDOCYTOSIS; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; ENDOCYTOSIS; FACTOR VIII; HUMANS; LIPOPROTEINS, LDL; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; LYSINE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84936805995     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.650911     Document Type: Article

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