C1 domain residues Lys 2092 and Phe 2093 are of major importance for the endocytic uptake of coagulation factor VIII

International Journal of Biochemistry and Cell Biology

Volumn 43, Issue 8, 2011, Pages 1114-1121

  Meems, Henriët ^a,b   Van Den Biggelaar, Maartje ^a   Rondaij, Mariska ^a   Van Der Zwaan, Carmen ^a   Mertens, Koen ^a,b,c   Meijer, Alexander B ^a,c  

^a SANQUIN RESEARCH   (Netherlands)

^b CENTRAL LABORATORY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cell surface binding; Endocytosis; Factor VIII; Flow cytometry; Low density lipoprotein receptor related protein (LRP)

Indexed keywords

AMINO ACID; BLOOD CLOTTING FACTOR 8; GREEN FLUORESCENT PROTEIN; HEPARIN; LOW DENSITY LIPOPROTEIN RECEPTOR; LYSINE; PHENYLALANINE; SMALL INTERFERING RNA; YELLOW FLUORESCENT PROTEIN;

ARTICLE; BINDING SITE; CELL SURFACE; CONFOCAL MICROSCOPY; ENDOCYTOSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEMBRANE BINDING; RECEPTOR BINDING; SURFACE PLASMON RESONANCE;

BINDING SITES; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; ENDOCYTOSIS; FACTOR VIII; FLOW CYTOMETRY; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; LYSINE; PHENYLALANINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79958736314     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.03.014     Document Type: Article

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