Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites

Experimental Cell Research

Volumn 260, Issue 1, 2000, Pages 30-39

  Cechetto, Jonathan D ^a   Gupta, Radhey S ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Electron microscopy; Hsp75; Hsp90 homolog; Immunogold; Mitochondria; Secretory granules; TRAP 1

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90; MITOCHONDRIAL MATRIX PROTEIN; TRAP 1 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD STAINING; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; SECRETORY GRANULE; TISSUE DISTRIBUTION; WESTERN BLOTTING;

EID: 0034633963     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4983     Document Type: Article

References (52)

1. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor
2. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties
3. Tumor necrosis factor receptor-mediated signaling pathways
4. A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock
5. A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses
6. The endosymbiont hypothesis revisited
7. Evolution of HSP70 gene and its implications regarding relationships between archaebacteria, eubacteria, and eukaryotes
8. Phylogenetic analysis of the 90 kD heat shock family of protein sequences and an examination of the relationship among animals, plants, and fungi species
9. Evolution of the chaperonin families (Hsp60, Hsp10 and Tcp-1) of proteins and the origin of eukaryotic cells
10. Mitochondrial proteins at unexpected cellular locations: Export of proteins from mitochondria from an evolutionary perspective
11. Localization of mitochondrial 60-kD heat shock chaperonin protein (Hsp60) in pituitary growth hormone secretory granules and pancreatic zymogen granules
12. Mitochondrial-matrix proteins at unexpected locations: Are they exported?
13. Expression of human 60-kD heat shock protein (HSP60 or P1) in Escherichia coli and the development and characterization of corresponding monoclonal antibodies
14. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells
15. A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARalpha
16. Double immunocytochemical labeling applying the protein A-gold technique
17. Mitochondrial matrix localization of a protein altered in mutants resistant to the microtubule inhibitor podophyllotoxin
18. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen
19. The isolation of outer and innner mitochondrial membranes
20. Survey and update of outer and inner mitochondrial membranes
21. cDNA cloning and characterization of a novel 16 kDa protein located in zymogen granules of rat pancreas and goblet cells of the gut
22. Protein import into mitochondria
23. Tumor necrosis factor is delivered to mitochondria where a tumor necrosis factor-binding protein is localized
24. Tumor necrosis factor receptor superfamily
25. The retinoblastoma protein: A master regulator of cell cycle, differentiation and apoptosis
26. Retinoblastoma protein family in cell cycle and cancer: A review
27. The retinoblastoma protein as a fundamental mediator of growth and differentiation signals
28. Recent advances in the molecular basis of TNF signal transduction
29. Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity
30. Tumor necrosis factor receptor superfamily members and their ligands
31. Tumour suppressor genes and molecular chaperones
32. The retinoblastoma protein: More than a tumor suppressor
33. The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetyl-galactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region: The key enzyme for the chain initiation ofheparan sulfate
34. The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate
35. Both tumor necrosis factor receptors, TNFR60 and TNFR80, are involved in signaling endothelial tissue factor expression by juxtacrine tumor necrosis factor alpha
36. Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration
37. How chaperones fold proteins
38. Hsp90 chaperones protein folding in vitro
39. The 90-kDa molecular chaperone family: Structure, function, and clinical applications - A comprehensive review
40. Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol
41. Interrelationships of endoplasmic reticulum, mitochondria, intermediate filaments, and microtubules - A quadruple fluorescence labeling study
42. Mitochondria, molecular chaperone proteins and the in vivo assembly of microtubules
43. Enhancement in amount of P1 (hsp60) in mutants of Chinese hamster ovary (CHO-K1) cells exhibiting increases in the A system of amino acid transport
44. An interaction between p21ras and heat shock protein hsp60, a chaperonin
45. Human peripheral gamma delta T cells recognize hsp60 molecules on Daudi Burkitt's lymphoma cells
46. Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane
47. Identification of a novel member of mouse hsp70 family: Its association with cellular mortal phenotype
48. Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family
49. Identification of early pregnancy factor as chaperonin 10: Implications for understanding its role
50. Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells
51. p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation