Dissolution and Solubility Enhancement of the Highly Lipophilic Drug Phenytoin via Interaction with Poly(N-isopropylacrylamide-co-vinylpyrrolidone) Excipients

Molecular Pharmaceutics

Volumn 12, Issue 7, 2015, Pages 2537-2543

  Widanapathirana, Lakmini ^a   Tale, Swapnil ^a   Reineke, Theresa M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

crystallization inhibition; dissolution; phenytoin; poly(NIPAAm co VP); supersaturation maintenance

Indexed keywords

2 PYRROLIDONE DERIVATIVE; EXCIPIENT; PHENYTOIN; POLY(N ISOPROPYLACRYLAMIDE CO VINYLPYRROLIDONE); POLY(N ISOPROPYLACRYLAMIDE); UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; ANTICONVULSIVE AGENT; N-ISOPROPYLACRYLAMIDE; N-VINYL-2-PYRROLIDINONE; POLYMER; SOLUTION AND SOLUBILITY; WATER;

AREA UNDER THE CURVE; ARTICLE; CALORIMETRY; CRYSTALLIZATION; DISSOLUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; HYDROGEN BOND; IN VITRO STUDY; LIPOPHILICITY; MOLECULAR WEIGHT; POLYMERIZATION; PRIORITY JOURNAL; SPRAY DRYING; TEMPERATURE; X RAY POWDER DIFFRACTION; BIOAVAILABILITY; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; MEDICINAL CHEMISTRY; PROCEDURES; SOLUBILITY; SOLUTION AND SOLUBILITY; X RAY DIFFRACTION;

ACRYLAMIDES; ANTICONVULSANTS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; EXCIPIENTS; HYDROGEN BONDING; PHENYTOIN; POLYMERS; PYRROLIDINONES; SOLUBILITY; SOLUTIONS; TEMPERATURE; WATER; X-RAY DIFFRACTION;

EID: 84936792234     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00202     Document Type: Article

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