-
1
-
-
84876149257
-
Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence
-
Mohd Hanafiah, K., Groeger, J., Flaxman, A.D., &, Wiersma, S.T., Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 57, 1333-1342 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 1333-1342
-
-
Mohd Hanafiah, K.1
Groeger, J.2
Flaxman, A.D.3
Wiersma, S.T.4
-
2
-
-
84891736446
-
High concordance of SVR4, SVR12, and SVR24 in patients with HCV infection who have received treatment with sofosbuvir
-
Lawitz, E., et al,. High concordance of SVR4, SVR12, and SVR24 in patients with HCV infection who have received treatment with sofosbuvir. J. Hepatol. 58, S348 (2013).
-
(2013)
J. Hepatol.
, vol.58
, pp. S348
-
-
Lawitz, E.1
-
3
-
-
84896267601
-
New antiviral agents for the treatment of hepatitis C: ABT-450
-
Carrion, A.F., Gutierrez, J., &, Martin, P., New antiviral agents for the treatment of hepatitis C: ABT-450. Expert Opin. Pharmacother. 15, 711-716 (2014).
-
(2014)
Expert Opin. Pharmacother.
, vol.15
, pp. 711-716
-
-
Carrion, A.F.1
Gutierrez, J.2
Martin, P.3
-
4
-
-
84890939899
-
Antiviral treatment of hepatitis C virus infection and factors affecting efficacy
-
Zhu, Y., &, Chen, S., Antiviral treatment of hepatitis C virus infection and factors affecting efficacy. World J. Gastroenterol. WJG 19, 8963-8973 (2013).
-
(2013)
World J. Gastroenterol. WJG
, vol.19
, pp. 8963-8973
-
-
Zhu, Y.1
Chen, S.2
-
5
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
Manns, M.P., et al,. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358, 958-965 (2001).
-
(2001)
Lancet
, vol.358
, pp. 958-965
-
-
Manns, M.P.1
-
6
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried, M.W., et al,. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 347, 975-982 (2002).
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
-
7
-
-
79959438789
-
Telaprevir for previously untreated chronic hepatitis C virus infection
-
Jacobson, I.M., et al,. Telaprevir for previously untreated chronic hepatitis C virus infection. N. Engl. J. Med. 364, 2405-2416 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2405-2416
-
-
Jacobson, I.M.1
-
8
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
Poordad, F., et al,. Boceprevir for untreated chronic HCV genotype 1 infection. N. Engl. J. Med. 364, 1195-1206 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 1195-1206
-
-
Poordad, F.1
-
9
-
-
84900326091
-
Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis
-
Kowdley, K.V., et al,. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N. Engl. J. Med. 370, 1879-1888 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 1879-1888
-
-
Kowdley, K.V.1
-
10
-
-
84892761609
-
Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection
-
Everson, G.T., et al,. Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection. Gastroenterology 146, 420-429 (2014).
-
(2014)
Gastroenterology
, vol.146
, pp. 420-429
-
-
Everson, G.T.1
-
11
-
-
84901367368
-
Combination oral, hepatitis C antiviral therapy for 6 or 12 weeks: Results of the SYNERGY Trial
-
Abstr 27LB
-
Kohli, A., et al,. Combination oral, hepatitis C antiviral therapy for 6 or 12 weeks: Results of the SYNERGY Trial. 21st CROI Abstr 27LB (2014).
-
(2014)
21st CROI
-
-
Kohli, A.1
-
12
-
-
84871814966
-
Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C
-
Gane, E.J., et al,. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N. Engl. J. Med. 368, 34-44 (2013).
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 34-44
-
-
Gane, E.J.1
-
13
-
-
84900339263
-
Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
-
Afdhal, N., et al,. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N. Engl. J. Med. 370, 1889-1898 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 1889-1898
-
-
Afdhal, N.1
-
14
-
-
84898449283
-
Efficacy and safety of sofosbuvir in treatment of chronic hepatitis C: The dawn of the a new era
-
Gentile, I., et al,. Efficacy and safety of sofosbuvir in treatment of chronic hepatitis C: The dawn of the a new era. Rev. Recent Clin. Trials 9, 1-7 (2014).
-
(2014)
Rev. Recent Clin. Trials
, vol.9
, pp. 1-7
-
-
Gentile, I.1
-
15
-
-
0032475822
-
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
-
Neumann, A.U., et al,. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 282, 103-107 (1998).
-
(1998)
Science
, vol.282
, pp. 103-107
-
-
Neumann, A.U.1
-
16
-
-
34447093479
-
Triphasic decline of hepatitis C virus RNA during antiviral therapy
-
Dahari, H., Ribeiro, R.M., &, Perelson, A.S., Triphasic decline of hepatitis C virus RNA during antiviral therapy. Hepatology 46, 16-21 (2007).
-
(2007)
Hepatology
, vol.46
, pp. 16-21
-
-
Dahari, H.1
Ribeiro, R.M.2
Perelson, A.S.3
-
17
-
-
0037806029
-
Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon
-
Herrmann, E., Lee, J.-H., Marinos, G., Modi, M., &, Zeuzem, S., Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon. Hepatology 37, 1351-1358 (2003).
-
(2003)
Hepatology
, vol.37
, pp. 1351-1358
-
-
Herrmann, E.1
Lee, J.-H.2
Marinos, G.3
Modi, M.4
Zeuzem, S.5
-
18
-
-
34249896188
-
Modeling hepatitis C virus dynamics: Liver regeneration and critical drug efficacy
-
Dahari, H., Lo, A., Ribeiro, R.M., &, Perelson, A.S., Modeling hepatitis C virus dynamics: liver regeneration and critical drug efficacy. J. Theor. Biol. 247, 371-381 (2007).
-
(2007)
J. Theor. Biol.
, vol.247
, pp. 371-381
-
-
Dahari, H.1
Lo, A.2
Ribeiro, R.M.3
Perelson, A.S.4
-
19
-
-
79954595958
-
Design evaluation and optimization for models of hepatitis C viral dynamics
-
Guedj, J., Bazzoli, C., Neumann, A.U., &, Mentré, F., Design evaluation and optimization for models of hepatitis C viral dynamics. Stat. Med. 30, 1045-1056 (2011).
-
(2011)
Stat. Med.
, vol.30
, pp. 1045-1056
-
-
Guedj, J.1
Bazzoli, C.2
Neumann, A.U.3
Mentré, F.4
-
20
-
-
84912074146
-
Inferring viral dynamics in chronically HCV infected patients from the spatial distribution of infected hepatocytes
-
Graw, F., et al,. Inferring viral dynamics in chronically HCV infected patients from the spatial distribution of infected hepatocytes. PLoS Comput. Biol. 10, e1003934 (2014).
-
(2014)
PLoS Comput. Biol.
, vol.10
, pp. e1003934
-
-
Graw, F.1
-
21
-
-
84888305998
-
Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver
-
Kandathil, A.J., et al,. Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver. Gastroenterology 145, 1404-1413.e10 (2013).
-
(2013)
Gastroenterology
, vol.145
, pp. 1404-1413e10
-
-
Kandathil, A.J.1
-
22
-
-
1542377471
-
Antiviral action of ribavirin in chronic hepatitis C
-
Pawlotsky, J.-M., et al,. Antiviral action of ribavirin in chronic hepatitis C. Gastroenterology 126, 703-714 (2004).
-
(2004)
Gastroenterology
, vol.126
, pp. 703-714
-
-
Pawlotsky, J.-M.1
-
23
-
-
84889635179
-
Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C
-
Rotman, Y., et al,. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut 63, 161-169 (2014).
-
(2014)
Gut
, vol.63
, pp. 161-169
-
-
Rotman, Y.1
-
24
-
-
84890552666
-
Impact of ribavirin priming on viral kinetics and treatment response in chronic hepatitis C genotype 1 infection
-
Mihm, U., et al,. Impact of ribavirin priming on viral kinetics and treatment response in chronic hepatitis C genotype 1 infection. J. Viral Hepat. 21, 42-52 (2014).
-
(2014)
J. Viral Hepat.
, vol.21
, pp. 42-52
-
-
Mihm, U.1
-
25
-
-
0038820380
-
Viral dynamics and response differences in HCV-infected African American and white patients treated with IFN and ribavirin
-
Layden-Almer, J.E., Ribeiro, R.M., Wiley, T., Perelson, A.S., &, Layden, T.J., Viral dynamics and response differences in HCV-infected African American and white patients treated with IFN and ribavirin. Hepatology 37, 1343-1350 (2003).
-
(2003)
Hepatology
, vol.37
, pp. 1343-1350
-
-
Layden-Almer, J.E.1
Ribeiro, R.M.2
Wiley, T.3
Perelson, A.S.4
Layden, T.J.5
-
26
-
-
11144330097
-
Modelling how ribavirin improves interferon response rates in hepatitis C virus infection
-
Dixit, N.M., Layden-Almer, J.E., Layden, T.J., &, Perelson, A.S., Modelling how ribavirin improves interferon response rates in hepatitis C virus infection. Nature 432, 922-924 (2004).
-
(2004)
Nature
, vol.432
, pp. 922-924
-
-
Dixit, N.M.1
Layden-Almer, J.E.2
Layden, T.J.3
Perelson, A.S.4
-
27
-
-
77952581566
-
A comprehensive hepatitis C viral kinetic model explaining cure
-
Snoeck, E., et al,. A comprehensive hepatitis C viral kinetic model explaining cure. Clin. Pharmacol. Ther. 87, 706-713 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.87
, pp. 706-713
-
-
Snoeck, E.1
-
28
-
-
77953893773
-
Ribavirin improves early responses to peginterferon through improved interferon signaling
-
Feld, J.J., et al,. Ribavirin improves early responses to peginterferon through improved interferon signaling. Gastroenterology 139, 154-162.e4 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 154-162e4
-
-
Feld, J.J.1
-
29
-
-
65449171953
-
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
-
Hézode, C., et al,. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N. Engl. J. Med. 360, 1839-1850 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1839-1850
-
-
Hézode, C.1
-
30
-
-
77950817619
-
Telaprevir for previously treated chronic HCV infection
-
McHutchison, J.G., et al,. Telaprevir for previously treated chronic HCV infection. N. Engl. J. Med. 362, 1292-1303 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 1292-1303
-
-
McHutchison, J.G.1
-
31
-
-
84901044326
-
ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV
-
Ferenci, P., et al,. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N. Engl. J. Med. 370, 1983-1992 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 1983-1992
-
-
Ferenci, P.1
-
32
-
-
78751545582
-
Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models
-
Thomas, E., et al,. Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models. Hepatology 53, 32-41 (2011).
-
(2011)
Hepatology
, vol.53
, pp. 32-41
-
-
Thomas, E.1
-
33
-
-
0021277886
-
Alternative approaches to estimation of population pharmacokinetic parameters: Comparison with the nonlinear mixed-effect model
-
Steimer, J.L., Mallet, A., Golmard, J.L., &, Boisvieux, J.F., Alternative approaches to estimation of population pharmacokinetic parameters: comparison with the nonlinear mixed-effect model. Drug Metab. Rev. 15, 265-292 (1984).
-
(1984)
Drug Metab. Rev.
, vol.15
, pp. 265-292
-
-
Steimer, J.L.1
Mallet, A.2
Golmard, J.L.3
Boisvieux, J.F.4
-
34
-
-
33750740728
-
Extension of the SAEM algorithm to left-censored data in nonlinear mixed-effects model: Application to HIV dynamics model
-
Samson, A., Lavielle, M., &, Mentré, F., Extension of the SAEM algorithm to left-censored data in nonlinear mixed-effects model: application to HIV dynamics model. Comput. Stat. Data Anal. 51, 1562-1574 (2006).
-
(2006)
Comput. Stat. Data Anal.
, vol.51
, pp. 1562-1574
-
-
Samson, A.1
Lavielle, M.2
Mentré, F.3
-
35
-
-
0035216180
-
Ways to fit a PK model with some data below the quantification limit
-
Beal, S.L., Ways to fit a PK model with some data below the quantification limit. J. Pharmacokinet. Pharmacodyn. 28, 481-504 (2001).
-
(2001)
J. Pharmacokinet. Pharmacodyn.
, vol.28
, pp. 481-504
-
-
Beal, S.L.1
-
36
-
-
78650684954
-
Evaluations of Bayesian and maximum likelihood methods in PK models with below-quantification-limit data
-
Yang, S., &, Roger, J., Evaluations of Bayesian and maximum likelihood methods in PK models with below-quantification-limit data. Pharm. Stat. 9, 313-330 (2010).
-
(2010)
Pharm. Stat.
, vol.9
, pp. 313-330
-
-
Yang, S.1
Roger, J.2
-
37
-
-
84904730378
-
Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors
-
McGivern, D.R., et al,. Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors. Gastroenterology 147, 453-462.e7 (2014).
-
(2014)
Gastroenterology
, vol.147
, pp. 453-462e7
-
-
McGivern, D.R.1
-
38
-
-
65549148167
-
Modeling hepatitis C virus kinetics under therapy using pharmacokinetic and pharmacodynamic information
-
Shudo, E., Ribeiro, R.M., &, Perelson, A.S., Modeling hepatitis C virus kinetics under therapy using pharmacokinetic and pharmacodynamic information. Expert Opin. Drug Metab. Toxicol. 5, 321-332 (2009).
-
(2009)
Expert Opin. Drug Metab. Toxicol.
, vol.5
, pp. 321-332
-
-
Shudo, E.1
Ribeiro, R.M.2
Perelson, A.S.3
-
39
-
-
63249083916
-
Modelling of viral dynamics in hepatitis B and hepatitis C clinical trials
-
Sypsa, V., &, Hatzakis, A., Modelling of viral dynamics in hepatitis B and hepatitis C clinical trials. Stat. Med. 27, 6505-6521 (2008).
-
(2008)
Stat. Med.
, vol.27
, pp. 6505-6521
-
-
Sypsa, V.1
Hatzakis, A.2
-
40
-
-
84936790641
-
A pharmacokinetic-viral kinetic model describes the effect of alisporivir monotherapy or in combination with peg-IFN on hepatitis C virologic response
-
(in press)
-
Nguyen, T.H.T., Mentré, F., Yu, J., Levi, M., &, Guedj, J., A pharmacokinetic-viral kinetic model describes the effect of alisporivir monotherapy or in combination with peg-IFN on hepatitis C virologic response. Clin. Pharmacol. Ther. (in press).
-
Clin. Pharmacol. Ther.
-
-
Nguyen, T.H.T.1
Mentré, F.2
Yu, J.3
Levi, M.4
Guedj, J.5
-
41
-
-
84906089509
-
Using pharmacokinetic and viral kinetic modeling to estimate the antiviral effectiveness of telaprevir, boceprevir and Peg-IFN during triple therapy in treatment-experienced HCV infected cirrhotic patients (ANRS CO20-CUPIC)
-
Laouénan, C., et al,. Using pharmacokinetic and viral kinetic modeling to estimate the antiviral effectiveness of telaprevir, boceprevir and Peg-IFN during triple therapy in treatment-experienced HCV infected cirrhotic patients (ANRS CO20-CUPIC). Antimicrob. Agents Chemother. (2014). doi: 10.1128/AAC.02611-14
-
(2014)
Antimicrob. Agents Chemother.
-
-
Laouénan, C.1
-
42
-
-
1242269757
-
Simultaneous vs. Sequential analysis for population PK/PD data I: Best-case performance
-
Zhang, L., Beal, S.L., &, Sheiner, L.B., Simultaneous vs. sequential analysis for population PK/PD data I: best-case performance. J. Pharmacokinet. Pharmacodyn. 30, 387-404 (2003).
-
(2003)
J. Pharmacokinet. Pharmacodyn.
, vol.30
, pp. 387-404
-
-
Zhang, L.1
Beal, S.L.2
Sheiner, L.B.3
-
43
-
-
84861047324
-
Evaluation of IPPSE, an alternative method for sequential population PKPD analysis
-
Lacroix, B.D., Friberg, L.E., &, Karlsson, M.O., Evaluation of IPPSE, an alternative method for sequential population PKPD analysis. J. Pharmacokinet. Pharmacodyn. 39, 177-193 (2012).
-
(2012)
J. Pharmacokinet. Pharmacodyn.
, vol.39
, pp. 177-193
-
-
Lacroix, B.D.1
Friberg, L.E.2
Karlsson, M.O.3
-
44
-
-
57049184586
-
Evaluation of drugs in pediatrics using K-PD models: Perspectives
-
Tod, M., Evaluation of drugs in pediatrics using K-PD models: perspectives. Fundam. Clin. Pharmacol. 22, 589-594 (2008).
-
(2008)
Fundam. Clin. Pharmacol.
, vol.22
, pp. 589-594
-
-
Tod, M.1
-
45
-
-
84936790642
-
A hepatitis C virus infection model with time-varying drug effectiveness: Solution and analysis
-
Conway, J.M., &, Perelson, A.S., A hepatitis C virus infection model with time-varying drug effectiveness: solution and analysis. PLoS Comput. Biol. 10, e1003769 (2014).
-
(2014)
PLoS Comput. Biol.
, vol.10
, pp. e1003769
-
-
Conway, J.M.1
Perelson, A.S.2
-
46
-
-
84863396230
-
Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128)
-
Guedj, J., Dahari, H., Shudo, E., Smith, P., &, Perelson, A.S., Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128). Hepatology 55, 1030-1037 (2012).
-
(2012)
Hepatology
, vol.55
, pp. 1030-1037
-
-
Guedj, J.1
Dahari, H.2
Shudo, E.3
Smith, P.4
Perelson, A.S.5
-
47
-
-
84898603709
-
Analysis of the hepatitis C viral kinetics during administration of two nucleotide analogues: Sofosbuvir (GS-7977) and GS-0938
-
Guedj, J., et al,. Analysis of the hepatitis C viral kinetics during administration of two nucleotide analogues: sofosbuvir (GS-7977) and GS-0938. Antivir. Ther. 19, 211-220 (2014).
-
(2014)
Antivir. Ther.
, vol.19
, pp. 211-220
-
-
Guedj, J.1
-
48
-
-
35648968189
-
Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor β-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine (psi-6130) and identification of a novel active 5′-triphosphate species
-
Ma, H., et al,. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor β-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine (psi-6130) and identification of a novel active 5′-triphosphate species. J. Biol. Chem. 282, 29812-29820 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 29812-29820
-
-
Ma, H.1
-
49
-
-
84859716196
-
Understanding silibinin's modes of action against HCV using viral kinetic modeling
-
Guedj, J., Dahari, H., Pohl, R.T., Ferenci, P., &, Perelson, A.S., Understanding silibinin's modes of action against HCV using viral kinetic modeling. J. Hepatol. 56, 1019-1024 (2012).
-
(2012)
J. Hepatol.
, vol.56
, pp. 1019-1024
-
-
Guedj, J.1
Dahari, H.2
Pohl, R.T.3
Ferenci, P.4
Perelson, A.S.5
-
50
-
-
33846081516
-
Mathematical modeling of subgenomic hepatitis C virus replication in Huh-7 cells
-
Dahari, H., Ribeiro, R.M., Rice, C.M., &, Perelson, A.S., Mathematical modeling of subgenomic hepatitis C virus replication in Huh-7 cells. J. Virol. 81, 750-760 (2007).
-
(2007)
J. Virol.
, vol.81
, pp. 750-760
-
-
Dahari, H.1
Ribeiro, R.M.2
Rice, C.M.3
Perelson, A.S.4
-
51
-
-
84883319848
-
Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle
-
Binder, M., et al,. Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle. PLoS Pathog. 9, e1003561 (2013).
-
(2013)
PLoS Pathog.
, vol.9
, pp. e1003561
-
-
Binder, M.1
-
52
-
-
67449089969
-
Modeling subgenomic hepatitis C virus RNA kinetics during treatment with alpha interferon
-
Dahari, H., Sainz, B. Jr., Perelson, A.S., &, Uprichard, S.L., Modeling subgenomic hepatitis C virus RNA kinetics during treatment with alpha interferon. J. Virol. 83, 6383-6390 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 6383-6390
-
-
Dahari, H.1
Sainz, Jr.B.2
Perelson, A.S.3
Uprichard, S.L.4
-
53
-
-
84898622258
-
A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants
-
Ivanisenko, N.V., et al,. A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants. PloS One 9, e91502 (2014).
-
(2014)
PloS One
, vol.9
, pp. e91502
-
-
Ivanisenko, N.V.1
-
54
-
-
84861127035
-
Pharmacokinetic/Pharmacodynamic predictors of clinical potency for hepatitis C virus nonnucleoside polymerase and protease inhibitors
-
Reddy, M.B., et al,. Pharmacokinetic/Pharmacodynamic predictors of clinical potency for hepatitis C virus nonnucleoside polymerase and protease inhibitors. Antimicrob. Agents Chemother. 56, 3144-3156 (2012).
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 3144-3156
-
-
Reddy, M.B.1
-
55
-
-
34548758435
-
Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
-
Kieffer, T.L., et al,. Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology 46, 631-639 (2007).
-
(2007)
Hepatology
, vol.46
, pp. 631-639
-
-
Kieffer, T.L.1
-
56
-
-
84866177809
-
Quantifying the diversification of hepatitis C virus (HCV) during primary infection: Estimates of the in vivo mutation rate
-
Ribeiro, R.M., et al,. Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate. PLoS Pathog. 8, e1002881 (2012).
-
(2012)
PLoS Pathog.
, vol.8
, pp. e1002881
-
-
Ribeiro, R.M.1
-
57
-
-
66149098217
-
Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo
-
Cuevas, J.M., González-Candelas, F., Moya, A., &, Sanjuán, R., Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo. J. Virol. 83, 5760-5764 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 5760-5764
-
-
Cuevas, J.M.1
González-Candelas, F.2
Moya, A.3
Sanjuán, R.4
-
58
-
-
77953013128
-
Rapid emergence of protease inhibitor resistance in hepatitis C virus
-
Rong, L., Dahari, H., Ribeiro, R.M., &, Perelson, A.S., Rapid emergence of protease inhibitor resistance in hepatitis C virus. Sci. Transl. Med. 2, 30ra32 (2010).
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 30ra32
-
-
Rong, L.1
Dahari, H.2
Ribeiro, R.M.3
Perelson, A.S.4
-
59
-
-
77954598121
-
A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants
-
Adiwijaya, B.S., et al,. A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants. PLoS Comput. Biol. 6, e1000745 (2010).
-
(2010)
PLoS Comput. Biol.
, vol.6
, pp. e1000745
-
-
Adiwijaya, B.S.1
-
60
-
-
84857474172
-
A viral dynamic model for treatment regimens with direct-acting antivirals for chronic hepatitis C infection
-
Adiwijaya, B.S., et al,. A viral dynamic model for treatment regimens with direct-acting antivirals for chronic hepatitis C infection. PLoS Comput. Biol. 8, e1002339 (2012).
-
(2012)
PLoS Comput. Biol.
, vol.8
, pp. e1002339
-
-
Adiwijaya, B.S.1
-
61
-
-
48749099989
-
Peginterferon alfa-2a and ribavirin for 24 weeks in hepatitis C type 1 and 4 patients with rapid virological response
-
Ferenci, P., et al,. Peginterferon alfa-2a and ribavirin for 24 weeks in hepatitis C type 1 and 4 patients with rapid virological response. Gastroenterology 135, 451-458 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 451-458
-
-
Ferenci, P.1
-
62
-
-
78049452611
-
Individualized treatment with combination of Peg-interferon alpha 2b and ribavirin in patients infected with HCV genotype 3
-
Mangia, A., et al,. Individualized treatment with combination of Peg-interferon alpha 2b and ribavirin in patients infected with HCV genotype 3. J. Hepatol. 53, 1000-1005 (2010).
-
(2010)
J. Hepatol.
, vol.53
, pp. 1000-1005
-
-
Mangia, A.1
-
63
-
-
34548101708
-
Response prediction and treatment tailoring for chronic hepatitis C virus genotype 1 infection
-
Lindh, M., et al,. Response prediction and treatment tailoring for chronic hepatitis C virus genotype 1 infection. J. Clin. Microbiol. 45, 2439-2445 (2007).
-
(2007)
J. Clin. Microbiol.
, vol.45
, pp. 2439-2445
-
-
Lindh, M.1
-
64
-
-
70449732769
-
Early prediction of sustained virological response at day 3 of treatment with albinterferon-alpha-2b in patients with genotype 2/3 chronic hepatitis C
-
Neumann, A.U., et al,. Early prediction of sustained virological response at day 3 of treatment with albinterferon-alpha-2b in patients with genotype 2/3 chronic hepatitis C. Liver Int. 29, 1350-1355 (2009).
-
(2009)
Liver Int.
, vol.29
, pp. 1350-1355
-
-
Neumann, A.U.1
-
65
-
-
79957448889
-
Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: Implications for treatment duration
-
Guedj, J., &, Perelson, A.S., Second-phase hepatitis C virus RNA decline during telaprevir-based therapy increases with drug effectiveness: implications for treatment duration. Hepatology 53, 1801-1808 (2011).
-
(2011)
Hepatology
, vol.53
, pp. 1801-1808
-
-
Guedj, J.1
Perelson, A.S.2
-
66
-
-
78049527728
-
Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
-
Gane, E.J., et al,. Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 376, 1467-1475 (2010).
-
(2010)
Lancet
, vol.376
, pp. 1467-1475
-
-
Gane, E.J.1
-
67
-
-
84921028832
-
Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study
-
Gane, E.J., et al,. Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study. Liver Int. Off. J. Int. Assoc. Study Liver (2014). doi: 10.1111/liv.12588
-
(2014)
Liver Int. Off. J. Int. Assoc. Study Liver
-
-
Gane, E.J.1
-
68
-
-
33744723134
-
Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061
-
Herrmann, E., et al,. Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061. Antivir. Ther. 11, 371-376 (2006).
-
(2006)
Antivir. Ther.
, vol.11
, pp. 371-376
-
-
Herrmann, E.1
-
69
-
-
77449158033
-
Rapid HCV-RNA decline with once daily TMC435: A phase i study in healthy volunteers and hepatitis C patients
-
Reesink, H.W., et al,. Rapid HCV-RNA decline with once daily TMC435: a phase I study in healthy volunteers and hepatitis C patients. Gastroenterology 138, 913-921 (2010).
-
(2010)
Gastroenterology
, vol.138
, pp. 913-921
-
-
Reesink, H.W.1
-
70
-
-
84874644131
-
Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
-
Guedj, J., et al,. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proc. Natl. Acad. Sci. U. S. A. 110, 3991-3996 (2013).
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 3991-3996
-
-
Guedj, J.1
-
71
-
-
84876003551
-
Analysis of hepatitis C virus decline during treatment with the protease inhibitor danoprevir using a multiscale model
-
Rong, L., et al,. Analysis of hepatitis C virus decline during treatment with the protease inhibitor danoprevir using a multiscale model. PLoS Comput. Biol. 9, e1002959 (2013).
-
(2013)
PLoS Comput. Biol.
, vol.9
, pp. e1002959
-
-
Rong, L.1
-
72
-
-
84862684876
-
A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C
-
Lawitz, E.J., et al,. A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C. J. Hepatol. 57, 24-31 (2012).
-
(2012)
J. Hepatol.
, vol.57
, pp. 24-31
-
-
Lawitz, E.J.1
-
73
-
-
77956704553
-
Understanding hepatitis C viral dynamics with direct-acting antiviral agents due to the interplay between intracellular replication and cellular infection dynamics
-
Guedj, J., &, Neumann, A.U., Understanding hepatitis C viral dynamics with direct-acting antiviral agents due to the interplay between intracellular replication and cellular infection dynamics. J. Theor. Biol. 267, 330-340 (2010).
-
(2010)
J. Theor. Biol.
, vol.267
, pp. 330-340
-
-
Guedj, J.1
Neumann, A.U.2
-
74
-
-
83455236681
-
HCV infection by cell-to-cell transmission: Choice or necessity?
-
Carloni, G., Crema, A., Valli, M.B., Ponzetto, A., &, Clementi, M., HCV infection by cell-to-cell transmission: Choice or necessity? Curr. Mol. Med. 12, 83-95 (2012).
-
(2012)
Curr. Mol. Med.
, vol.12
, pp. 83-95
-
-
Carloni, G.1
Crema, A.2
Valli, M.B.3
Ponzetto, A.4
Clementi, M.5
-
76
-
-
79952477165
-
Stochastic theory of early viral infection: Continuous versus burst production of virions
-
Pearson, J.E., Krapivsky, P., &, Perelson, A.S., Stochastic theory of early viral infection: continuous versus burst production of virions. PLoS Comput. Biol. 7, e1001058 (2011).
-
(2011)
PLoS Comput. Biol.
, vol.7
, pp. e1001058
-
-
Pearson, J.E.1
Krapivsky, P.2
Perelson, A.S.3
-
77
-
-
84921485599
-
Sustained virological response with intravenous silibinin: Individualized IFN-free therapy via real-time modelling of HCV kinetics
-
Dahari, H., et al,. Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics. Liver Int. (2014) doi: 10.1111/liv.12692.
-
(2014)
Liver Int.
-
-
Dahari, H.1
-
78
-
-
84921447800
-
Can we use viral kinetic models to individualize treatment?
-
Guedj, J., &, Nguyen, T.H.T., Can we use viral kinetic models to individualize treatment? Liver Int. (2014) doi: 10.1111/liv.12736.
-
(2014)
Liver Int.
-
-
Guedj, J.1
Nguyen, T.H.T.2
-
79
-
-
84881125383
-
Influence of a priori information, designs, and undetectable data on individual parameters estimation and prediction of hepatitis C treatment outcome
-
Nguyen, T.H.T., Guedj, J., Yu, J., Levi, M., &, Mentré, F., Influence of a priori information, designs, and undetectable data on individual parameters estimation and prediction of hepatitis C treatment outcome. CPT Pharmacomet. Syst. Pharmacol. 2, e56 (2013).
-
(2013)
CPT Pharmacomet. Syst. Pharmacol.
, vol.2
, pp. e56
-
-
Nguyen, T.H.T.1
Guedj, J.2
Yu, J.3
Levi, M.4
Mentré, F.5
-
80
-
-
84555188619
-
Bistability and long-term cure in a within-host model of hepatitis C
-
DeBroy, S., Bolker, B.M., &, Martcheva, M., Bistability and long-term cure in a within-host model of hepatitis C. J. Biol. Syst. 19, 533-550 (2011).
-
(2011)
J. Biol. Syst.
, vol.19
, pp. 533-550
-
-
Debroy, S.1
Bolker, B.M.2
Martcheva, M.3
-
81
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco, W.R., Bravo, G., &, Parsons, J.C., The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev. 47, 331-385 (1995).
-
(1995)
Pharmacol. Rev.
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
82
-
-
34247897031
-
Interaction index and different methods for determining drug interaction in combination therapy
-
Lee, J.J., Kong, M., Ayers, G., &, Lotan, R., Interaction index and different methods for determining drug interaction in combination therapy. J. Biopharm. Stat. 17, 461-480 (2007).
-
(2007)
J. Biopharm. Stat.
, vol.17
, pp. 461-480
-
-
Lee, J.J.1
Kong, M.2
Ayers, G.3
Lotan, R.4
-
83
-
-
84864051750
-
Modeling quasispecies and drug resistance in hepatitis C patients treated with a protease inhibitor
-
Rong, L., Ribeiro, R.M., &, Perelson, A.S., Modeling quasispecies and drug resistance in hepatitis C patients treated with a protease inhibitor. Bull. Math. Biol. 74, 1789-1817 (2012).
-
(2012)
Bull. Math. Biol.
, vol.74
, pp. 1789-1817
-
-
Rong, L.1
Ribeiro, R.M.2
Perelson, A.S.3
-
84
-
-
33750987680
-
Predicting sustained virological response and anaemia in chronic hepatitis C patients treated with peginterferon alfa-2a (40KD) plus ribavirin
-
Snoeck, E., Wade, J.R., Duff, F., Lamb, M., &, Jorga, K., Predicting sustained virological response and anaemia in chronic hepatitis C patients treated with peginterferon alfa-2a (40KD) plus ribavirin. Br. J. Clin. Pharmacol. 62, 699-709 (2006).
-
(2006)
Br. J. Clin. Pharmacol.
, vol.62
, pp. 699-709
-
-
Snoeck, E.1
Wade, J.R.2
Duff, F.3
Lamb, M.4
Jorga, K.5
-
85
-
-
84936760892
-
A model-based illustrative exploratory approach to optimize the dosing of Peg-IFN and ribavirin in cirrhotic hepatitis C infected patients treated with triple therapy (ANRS CO20-CUPIC)
-
(in press)
-
Laouénan, C., et al,. A model-based illustrative exploratory approach to optimize the dosing of Peg-IFN and ribavirin in cirrhotic hepatitis C infected patients treated with triple therapy (ANRS CO20-CUPIC). CPT Pharmacomet. Syst. Pharmacol. (in press).
-
CPT Pharmacomet. Syst. Pharmacol.
-
-
Laouénan, C.1
-
86
-
-
84910149153
-
Predicting response to all-oral directly acting antiviral therapy for hepatitis C using results of Roche and Abbott HCV viral load assays
-
8, Abstr 865
-
Sidharthan, S., et al,. Predicting response to all-oral directly acting antiviral therapy for hepatitis C using results of Roche and Abbott HCV viral load assays. 23rd APASL 8, Abstr 865, S227-228 (2014).
-
(2014)
23rd APASL
, pp. S227-S228
-
-
Sidharthan, S.1
-
87
-
-
60849121716
-
Abbott RealTime hepatitis C virus (HCV) and Roche Cobas AmpliPrep/Cobas TaqMan HCV assays for prediction of sustained virological response to pegylated interferon and ribavirin in chronic hepatitis C patients
-
Matsuura, K., et al,. Abbott RealTime hepatitis C virus (HCV) and Roche Cobas AmpliPrep/Cobas TaqMan HCV assays for prediction of sustained virological response to pegylated interferon and ribavirin in chronic hepatitis C patients. J. Clin. Microbiol. 47, 385-389 (2009).
-
(2009)
J. Clin. Microbiol.
, vol.47
, pp. 385-389
-
-
Matsuura, K.1
-
88
-
-
33747048398
-
HCV RNA detection by TMA during the hepatitis C antiviral long-term treatment against cirrhosis (Halt-C) trial
-
Morishima, C., et al,. HCV RNA detection by TMA during the hepatitis C antiviral long-term treatment against cirrhosis (Halt-C) trial. Hepatology 44, 360-367 (2006).
-
(2006)
Hepatology
, vol.44
, pp. 360-367
-
-
Morishima, C.1
-
89
-
-
79851514111
-
Comparable performance of TMA and real-time PCR in detecting minimal residual hepatitis C viraemia at the end of antiviral therapy
-
Bortoletto, G., et al,. Comparable performance of TMA and real-time PCR in detecting minimal residual hepatitis C viraemia at the end of antiviral therapy. J. Clin. Virol. Off. Publ. Pan Am. Soc. Clin. Virol. 50, 217-220 (2011).
-
(2011)
J. Clin. Virol. Off. Publ. Pan Am. Soc. Clin. Virol.
, vol.50
, pp. 217-220
-
-
Bortoletto, G.1
|