Hydrogen sulfide protects spinal cord and induces autophagy via miR-30c in a rat model of spinal cord ischemia-reperfusion injury

Journal of Biomedical Science

Volumn 22, Issue 1, 2015, Pages

  Li, Lei ^a   Jiang, Hong Kun ^a   Li, Yun Peng ^a   Guo, Yan Ping ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Beclin 1; Microtubule associated protein 1 light chain 3 (LC3); miR 30c; Oxygen glucose deprivation (OGD)

Indexed keywords

BECLIN 1; HYDROGEN SULFIDE; LIGHT CHAIN 3; MEMBRANE PROTEIN; MICRORNA; MICRORNA 30C; MICROTUBULE ASSOCIATED PROTEIN 1; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG; MIRN30 MICRORNA, HUMAN; NEUROPROTECTIVE AGENT;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; FUNCTIONAL ASSESSMENT; GENE EXPRESSION; MALE; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; SPINAL CORD INFARCTION; SPINAL CORD ISCHEMIA; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; PATHOPHYSIOLOGY; SPINAL CORD INJURIES;

RATTUS;

ANIMALS; AUTOPHAGY; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN SULFIDE; MICRORNAS; NEUROPROTECTIVE AGENTS; RATS; REPERFUSION INJURY; SPINAL CORD INJURIES;

EID: 84936768733     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-015-0135-1     Document Type: Article

References (30)

1. Korkmaz K, Gedik HS, Budak AB, Erdem H, Lafci G, Karakilic E, et al. Effect of heparin on neuroprotection against spinal cord ischemia and reperfusion in rats. Eur Rev Med Pharmacol Sci. 2013;17:522-30.
2. Ege E, Ilhan A, Gurel A, Akyol O, Ozen S. Erdosteine ameliorates neurological outcome and oxidative stress due to ischemia/reperfusion injury in rabbit spinal cord. Eur J Vasc Endovasc Surg. 2004;28:379-86.
3. Kimura H. Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochem Int. 2013;63:492-7.
4. Guo W, Kan JT, Cheng ZY, Chen JF, Shen YQ, Xu J, et al. Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction. Oxid Med Cell Longev. 2012;2012:878052.
5. Wagner F, Asfar P, Calzia E, Radermacher P, Szabo C. Bench-to-bedside review: Hydrogen sulfide-the third gaseous transmitter: applications for critical care. Crit Care. 2009;13:213.
6. Henderson PW, Weinstein AL, Sohn AM, Jimenez N, Krijgh DD, Spector JA. Hydrogen sulfide attenuates intestinal ischemia-reperfusion injury when delivered in the post-ischemic period. J Gastroenterol Hepatol. 2010;25:1642-7.
7. Nieto-Diaz M, Esteban FJ, Reigada D, Muñoz-Galdeano T, Yunta M, Caballero-López M, et al. MicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics. Front Cell Neurosci. 2014;25(8):53.
8. Bijkerk R, van Solingen C, de Boer HC, van der Pol P, Khairoun M, de Bruin RG, et al. Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity. J Am Soc Nephrol. 2014;25(8):1710-22.
9. Forini F, Kusmic C, Nicolini G, Mariani L, Zucchi R, Matteucci M, et al. Triiodothyronine prevents cardiac ischemia/reperfusion mitochondrial impairment and cell loss by regulating miR30a/p53 axis. Endocrinology. 2014;155(11):4581-90.
10. Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S. A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of Bdnf in prefrontal cortex. Hum Mol Genet. 2008;17(19):3030-42.
11. Toldo S, Das A, Mezzaroma E, Chau VQ, Marchetti C, Durrant D, et al. Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice. Circ Cardiovasc Genet. 2014;7(3):311-20.
12. Wang P, Liang J, Li Y, Li J, Yang X, Zhang X, et al. Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing beclin 1-mediated autophagy. Neurochem Res. 2014;39(7):1279-91.
13. Kanno H, Ozawa H, Sekiguchi A, Itoi E. The role of autophagy in spinal cord injury. Autophagy. 2009;5(3):390-2.
14. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006;441:885-9.
15. Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, et al. Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer. BioMed Res Int. 2014;2014:462658.
16. Zhang Q, Huang C, Meng B, Tang TS, Yang HL. Changes in autophagy proteins in a rat model of spinal cord injury. Chin J Traumatol. 2014;17:193-7.
17. Ribas VT, Schnepf B, Challagundla M, Koch JC, Bahr M, Lingor P. Early and Sustained Activation of Autophagy in Degenerating Axons after Spinal Cord Injury. Brain Pathol. 2015;25(2):157-70.
18. Wang D, Ma Y, Li Z, Kang K, Sun X, Pan S, et al. The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice. Autophagy. 2012;8:954-62.
19. Wu YC, Wang XJ, Yu L, Chan FK, Cheng AS, Yu J, et al. Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells. PLoS One. 2012;7:e37572.
20. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 1995;12:1-21.
21. Beck J, Lenart B, Kintner DB, Sun D. Na-K-Cl cotransporter contributes to glutamate-mediated excitotoxicity. J Neurosci. 2003;23:5061-8.
22. Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X, et al. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy. 2009;5:816-23.
23. Tan BH, Wong PT, Bian JS. Hydrogen sulfide: a novel signaling molecule in the central nervous system. Neurochem Int. 2010;56:3-10.
24. Wang Q, Sun AY, Pardeike J, Muller RH, Simonyi A, Sun GY. Neuroprotective effects of a nanocrystal formulation of sPLA (2) inhibitor PX-18 in cerebral ischemia/reperfusion in gerbils. Brain Res. 2009;1285:188-95.
25. Hou H, Zhang L, Zhang L, Liu D, Mao Z, Du H, et al. Acute spinal cord injury in rats induces autophagy activation. Turk Neurosurg. 2014;24:369-73.
26. Tarabal O, Caldero J, Casas C, Oppenheim RW, Esquerda JE. Protein retention in the endoplasmic reticulum, blockade of programmed cell death and autophagy selectively occur in spinal cord motoneurons after glutamate receptor-mediated injury. Mol Cell Neurosci. 2005;29:283-98.
27. Yang X, Zhong X, Tanyi JL, Shen J, Xu C, Gao P, et al. mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochem Biophys Res Commun. 2013;431:617-22.
28. Hyrskyluoto A, Reijonen S, Kivinen J, Lindholm D, Korhonen L. GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway. Exp Cell Res. 2012;318(1):33-42.
29. Chang Y, Yan W, He X, Zhang L, Li C, Huang H, et al. miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Gastroenterology. 2012;143:177-87. e.8.
30. Kovaleva V, Mora R, Park YJ, Plass C, Chiramel AI, Bartenschlager R, et al. miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. Cancer Res. 2012;72:1763-72.