Viscoelastic Emulsion Improved the Bioaccessibility and Oral Bioavailability of Crystalline Compound: A Mechanistic Study Using in Vitro and in Vivo Models

Molecular Pharmaceutics

Volumn 12, Issue 7, 2015, Pages 2229-2236

  Ting, Yuwen ^a   Jiang, Yike ^a   Lan, Yaqi ^a   Xia, Chunxin ^a   Lin, Zhenyu ^a   Rogers, Michael A ^a,b   Huang, Qingrong ^a  

^a RUTGERS UNIVERSITY   (United States)

^b the State University of New Jersey   (United States)

Author keywords

bioaccessibility; bioavailability; in vitro lipolysis; pharmacokinetic; tangeretin; TIM 1; viscoelastic emulsion

Indexed keywords

KIDNEY INJURY MOLECULE 1; TANGERETIN; DRUG CARRIER; EMULSION; FLAVONE; FLAVONE DERIVATIVE; VISCOELASTIC SUBSTANCE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG SOLUBILITY; EMULSION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ILEUM; IN VITRO STUDY; IN VIVO STUDY; IONIC STRENGTH; JEJUNUM; LIPOLYSIS; MAXIMUM PLASMA CONCENTRATION; MECHANICS; MICELLIZATION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; SURFACE AREA; SUSPENSION; TEMPERATURE; VISCOELASTICITY; ANIMAL; BIOAVAILABILITY; CHEMISTRY; CRYSTALLIZATION; DIGESTION; DRUG EFFECTS; GASTROINTESTINAL TRACT; HUMAN; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PROCEDURES; SOLUBILITY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DIGESTION; DRUG CARRIERS; EMULSIONS; FEMALE; FLAVONES; GASTROINTESTINAL TRACT; HUMANS; INTESTINAL ABSORPTION; LIPOLYSIS; MICE; SOLUBILITY; VISCOELASTIC SUBSTANCES;

EID: 84936766897     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5007322     Document Type: Article

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