Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD

Human Molecular Genetics

Volumn 24, Issue 14, 2015, Pages 3982-3993

  Zhou, Xia ^a   Fan, Lucy X ^a   Peters, Dorien J M ^c   Trudel, Marie ^d   Bradner, James E ^e   Li, Xiaogang ^a,b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; HEAT SHOCK PROTEIN 90; POLYCYSTIN 1; PROTEASOME; PROTEIN; PROTEIN BRD4; PROTEIN P21; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; (+)-JQ1 COMPOUND; AZEPINE DERIVATIVE; BRD4 PROTEIN, HUMAN; BRD4 PROTEIN, MOUSE; MYC PROTEIN; NUCLEAR PROTEIN; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN; PROTEIN KINASE C; PROTEIN KINASE D; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG TARGETING; ENZYME DEGRADATION; EPIGENETICS; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE REPRESSION; GROWTH INHIBITION; IMMUNOHISTOCHEMISTRY; KIDNEY CYST; KIDNEY FUNCTION; KIDNEY POLYCYSTIC DISEASE; MALE; MOUSE; NEWBORN; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION SITE; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CYSTS; DISEASE MODEL; GENE TARGETING; GENETIC EPIGENESIS; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROCEDURES;

RODENTIA;

ANIMALS; AZEPINES; CELL PROLIFERATION; CYSTS; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; EPITHELIAL CELLS; FEMALE; GENE TARGETING; HEK293 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PHOSPHORYLATION; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION FACTORS; TRIAZOLES; TRPP CATION CHANNELS; UP-REGULATION;

EID: 84936759340     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv136     Document Type: Article

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