메뉴 건너뛰기




Volumn 28, Issue 7, 2015, Pages 943-950

Elevated homocysteine levels are associated with the metabolic syndrome and cardiovascular events in hypertensive patients

Author keywords

blood pressure; cerebrovascular disease; coronary heart disease; folate; homocysteine; hypertension; insulin resistance; metabolic syndrome; vitamin B12

Indexed keywords

ANTIHYPERTENSIVE AGENT; CYANOCOBALAMIN; FIBRINOGEN; FOLIC ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID; BIOLOGICAL MARKER;

EID: 84936752770     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpu248     Document Type: Article
Times cited : (84)

References (40)
  • 1
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 1995; 346:1395-1398.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 2
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995; 274:1049-1057.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 4
    • 3142729014 scopus 로고    scopus 로고
    • Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and cysteine
    • Stipanuk MH. Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 2004; 24:539-577.
    • (2004) Annu Rev Nutr , vol.24 , pp. 539-577
    • Stipanuk, M.H.1
  • 5
    • 2942558869 scopus 로고    scopus 로고
    • Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: The pleiotropic effects of folate supplementation
    • Hayden MR, Tyagi SC. Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation. Nutr J 2004; 3:4.
    • (2004) Nutr J , vol.3 , pp. 4
    • Hayden, M.R.1    Tyagi, S.C.2
  • 6
    • 0027092522 scopus 로고
    • Abdominal obesity and the metabolic syndrome
    • Bjntorp P. Abdominal obesity and the metabolic syndrome. Ann Med 1992; 24:465-468.
    • (1992) Ann Med , vol.24 , pp. 465-468
    • Bjntorp, P.1
  • 7
    • 33846420642 scopus 로고    scopus 로고
    • Metabolic syndrome
    • Opie LH. Metabolic syndrome. Circulation 2007; 115:e32-e35.
    • (2007) Circulation , vol.115 , pp. e32-e35
    • Opie, L.H.1
  • 8
    • 33846365989 scopus 로고    scopus 로고
    • Metabolic syndrome and risk of incident cardiovascular events and death: A systematic review and meta-analysis of longitudinal studies
    • Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, Montori VM. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007; 49:403-414.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 403-414
    • Gami, A.S.1    Witt, B.J.2    Howard, D.E.3    Erwin, P.J.4    Gami, L.A.5    Somers, V.K.6    Montori, V.M.7
  • 10
    • 0345375263 scopus 로고    scopus 로고
    • Hyperhomocysteinemia as a component of syndrome X
    • Oron-Herman M, Rosenthal T, Sela BA. Hyperhomocysteinemia as a component of syndrome X. Metabolism 2003; 52:1491-1495.
    • (2003) Metabolism , vol.52 , pp. 1491-1495
    • Oron-Herman, M.1    Rosenthal, T.2    Sela, B.A.3
  • 11
    • 29544431942 scopus 로고    scopus 로고
    • Plasma homocysteine and lipoprotein (a) levels in Turkish patients with metabolic syndrome
    • Guven A, Inanc F, Kilinc M, Ekerbicer H. Plasma homocysteine and lipoprotein (a) levels in Turkish patients with metabolic syndrome. Heart Vessels 2005; 20:290-295.
    • (2005) Heart Vessels , vol.20 , pp. 290-295
    • Guven, A.1    Inanc, F.2    Kilinc, M.3    Ekerbicer, H.4
  • 12
    • 33846612442 scopus 로고    scopus 로고
    • Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome
    • SMART Study Group
    • Hajer GR, van der Graaf Y, Olijhoek JK, Verhaar MC, Visseren FL; SMART Study Group. Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome. Heart 2007; 93:216-220.
    • (2007) Heart , vol.93 , pp. 216-220
    • Hajer, G.R.1    Van Der Graaf, Y.2    Olijhoek, J.K.3    Verhaar, M.C.4    Visseren, F.L.5
  • 14
    • 0033974804 scopus 로고    scopus 로고
    • Plasma homocysteine concentrations and insulin sensitivity in hypertensive subjects
    • Sheu WH, Lee WJ, Chen YT. Plasma homocysteine concentrations and insulin sensitivity in hypertensive subjects. Am J Hypertens 2000; 13:14-20.
    • (2000) Am J Hypertens , vol.13 , pp. 14-20
    • Sheu, W.H.1    Lee, W.J.2    Chen, Y.T.3
  • 15
    • 0036795697 scopus 로고    scopus 로고
    • Essential hypertension in adolescents: Association with insulin resistance and with metabolism of homocysteine and vitamins
    • Kahleov R, Palyzov D, Zva K, Zvov J, Hrach K, Novov I, Hyek J, Bendlov B, Kozich V. Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins. Am J Hypertens 2002; 15:857-864.
    • (2002) Am J Hypertens , vol.15 , pp. 857-864
    • Kahleov, R.1    Palyzov, D.2    Zva, K.3    Zvov, J.4    Hrach, K.5    Novov, I.6    Hyek, J.7    Bendlov, B.8    Kozich, V.9
  • 16
    • 33646054581 scopus 로고    scopus 로고
    • The relationship between the levels of plasma total homocysteine and insulin resistance in uncomplicated mild-to-moderate primary hypertension
    • Ustundag S, Arikan E, Sen S, Esgin H, Ciftci S. The relationship between the levels of plasma total homocysteine and insulin resistance in uncomplicated mild-to-moderate primary hypertension. J Hum Hypertens 2006; 20:379-381.
    • (2006) J Hum Hypertens , vol.20 , pp. 379-381
    • Ustundag, S.1    Arikan, E.2    Sen, S.3    Esgin, H.4    Ciftci, S.5
  • 17
    • 0033760301 scopus 로고    scopus 로고
    • Abnormalities of coagulation in hypertensive patients with reduced creatinine clearance
    • Catena C, Zingaro L, Casaccio D, Sechi LA. Abnormalities of coagulation in hypertensive patients with reduced creatinine clearance. Am J Med 2000; 109:556-561.
    • (2000) Am J Med , vol.109 , pp. 556-561
    • Catena, C.1    Zingaro, L.2    Casaccio, D.3    Sechi, L.A.4
  • 19
    • 0033790976 scopus 로고    scopus 로고
    • Increased fibrinogen levels and hemostatic abnormalities in patients with arteriolar nephrosclerosis: Association with cardiovascular events
    • Sechi LA, Zingaro L, Catena C, De Marchi S. Increased fibrinogen levels and hemostatic abnormalities in patients with arteriolar nephrosclerosis: association with cardiovascular events. Thromb Haemost 2000; 84:565-570.
    • (2000) Thromb Haemost , vol.84 , pp. 565-570
    • Sechi, L.A.1    Zingaro, L.2    Catena, C.3    De Marchi, S.4
  • 21
    • 0026446761 scopus 로고
    • Insulin hypersecretion: A distinctive feature between essential and secondary hypertension
    • Sechi LA, Melis A, Tedde R. Insulin hypersecretion: a distinctive feature between essential and secondary hypertension. Metabolism 1992; 41:1261-1266.
    • (1992) Metabolism , vol.41 , pp. 1261-1266
    • Sechi, L.A.1    Melis, A.2    Tedde, R.3
  • 23
    • 0037332162 scopus 로고    scopus 로고
    • Serum lipoprotein(a) concentrations and alcohol consumption in hypertension: Possible relevance for cardiovascular damage
    • Catena C, Novello M, Dotto L, De Marchi S, Sechi LA. Serum lipoprotein(a) concentrations and alcohol consumption in hypertension: possible relevance for cardiovascular damage. J Hypertens 2003; 21:281-288.
    • (2003) J Hypertens , vol.21 , pp. 281-288
    • Catena, C.1    Novello, M.2    Dotto, L.3    De Marchi, S.4    Sechi, L.A.5
  • 26
    • 84908304964 scopus 로고    scopus 로고
    • Plasma glucose levels and left ventricular diastolic function in nondiabetic hypertensive patients
    • Catena C, Colussi G, Martinis F, Pezzutto F, Sechi LA. Plasma glucose levels and left ventricular diastolic function in nondiabetic hypertensive patients. Am J Hypertens 2013; 26:1353-1361.
    • (2013) Am J Hypertens , vol.26 , pp. 1353-1361
    • Catena, C.1    Colussi, G.2    Martinis, F.3    Pezzutto, F.4    Sechi, L.A.5
  • 27
    • 40449086218 scopus 로고    scopus 로고
    • Relationship between metabolic syndrome categorized by newly recommended by International Diabetes Federation criteria with plasma homocysteine concentration
    • Rhee EJ, Hwang ST, Lee WY, Yoon JH, Kim BJ, Kim BS, Kang JH, Lee MH, Park JR, Sung KC. Relationship between metabolic syndrome categorized by newly recommended by International Diabetes Federation criteria with plasma homocysteine concentration. Endocr J 2007; 54:995-1002.
    • (2007) Endocr J , vol.54 , pp. 995-1002
    • Rhee, E.J.1    Hwang, S.T.2    Lee, W.Y.3    Yoon, J.H.4    Kim, B.J.5    Kim, B.S.6    Kang, J.H.7    Lee, M.H.8    Park, J.R.9    Sung, K.C.10
  • 30
    • 84878245810 scopus 로고    scopus 로고
    • The relationship between metabolic syndrome, cardiometabolic risk factors and inflammatory markers in a Tehranian population: The Tehran Lipid and Glucose Study
    • Zarkesh M, Faam B, Daneshpour MS, Azizi F, Hedayati M. The relationship between metabolic syndrome, cardiometabolic risk factors and inflammatory markers in a Tehranian population: the Tehran Lipid and Glucose Study. Intern Med 2012; 51:3329-3335.
    • (2012) Intern Med , vol.51 , pp. 3329-3335
    • Zarkesh, M.1    Faam, B.2    Daneshpour, M.S.3    Azizi, F.4    Hedayati, M.5
  • 33
    • 38049165775 scopus 로고    scopus 로고
    • Association between homocysteinemia and metabolic syndrome in patients with cardiovascular disease
    • Bellia C, Bivona G, Scazzone C, Ciaccio M. Association between homocysteinemia and metabolic syndrome in patients with cardiovascular disease. Ther Clin Risk Manag 2007; 3:999-1001.
    • (2007) Ther Clin Risk Manag , vol.3 , pp. 999-1001
    • Bellia, C.1    Bivona, G.2    Scazzone, C.3    Ciaccio, M.4
  • 35
    • 33745727436 scopus 로고    scopus 로고
    • Associations between serum insulin and homocysteine in a Swedish population-a potential link between the metabolic syndrome and hyperhomocysteinemia: The Skaraborg project
    • Bjck J, Hellgren M, Rtam L, Lindblad U. Associations between serum insulin and homocysteine in a Swedish population-a potential link between the metabolic syndrome and hyperhomocysteinemia: the Skaraborg project. Metabolism 2006; 55:1007-1013.
    • (2006) Metabolism , vol.55 , pp. 1007-1013
    • Bjck, J.1    Hellgren, M.2    Rtam, L.3    Lindblad, U.4
  • 37
    • 80051698675 scopus 로고    scopus 로고
    • Metabolic syndrome and serum homocysteine in patients with bipolar disorder and schizophrenia treated with second generation antipsychotics
    • Vuksan-usa B, Jakovljevi M, Sagud M, Mihaljevi Peleš A, Marinko D, Topi R, Mihaljevi S, Serti J. Metabolic syndrome and serum homocysteine in patients with bipolar disorder and schizophrenia treated with second generation antipsychotics. Psychiatry Res 2011; 189:21-25.
    • (2011) Psychiatry Res , vol.189 , pp. 21-25
    • Vuksan-Usa, B.1    Jakovljevi, M.2    Sagud, M.3    Mihaljevi Peleš, A.4    Marinko, D.5    Topi, R.6    Mihaljevi, S.7    Serti, J.8
  • 38
    • 0032779879 scopus 로고    scopus 로고
    • Plasma homocysteine concentrations in healthy volunteers are not related to differences in insulin-mediated glucose disposal
    • Abbasi F, Facchini F, Humphreys MH, Reaven GM. Plasma homocysteine concentrations in healthy volunteers are not related to differences in insulin-mediated glucose disposal. Atherosclerosis 1999; 146:175-178.
    • (1999) Atherosclerosis , vol.146 , pp. 175-178
    • Abbasi, F.1    Facchini, F.2    Humphreys, M.H.3    Reaven, G.M.4
  • 39
    • 0035093058 scopus 로고    scopus 로고
    • Plasma total homocysteine concentrations are unrelated to insulin sensitivity and components of the metabolic syndrome in healthy men
    • Godsland IF, Rosankiewicz JR, Proudler AJ, Johnston DG. Plasma total homocysteine concentrations are unrelated to insulin sensitivity and components of the metabolic syndrome in healthy men. J Clin Endocrinol Metab 2001; 86:719-723.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 719-723
    • Godsland, I.F.1    Rosankiewicz, J.R.2    Proudler, A.J.3    Johnston, D.G.4
  • 40
    • 33746683844 scopus 로고    scopus 로고
    • Plasma homocysteine concentrations in young individuals at increased risk of type 2 diabetes are associated with subtle differences in glomerular filtration rate but not with insulin resistance
    • Scher SA, Msig K, Stefan N, Hing HU, Fritsche A, Balletshofer BM. Plasma homocysteine concentrations in young individuals at increased risk of type 2 diabetes are associated with subtle differences in glomerular filtration rate but not with insulin resistance. Exp Clin Endocrinol Diabetes 2006; 114:306-309.
    • (2006) Exp Clin Endocrinol Diabetes , vol.114 , pp. 306-309
    • Scher, S.A.1    Msig, K.2    Stefan, N.3    Hing, H.U.4    Fritsche, A.5    Balletshofer, B.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.