The correlation of plasma homocysteine with insulin resistance in polycystic ovary syndrome

Journal of Obstetrics and Gynaecology Research

Volumn 34, Issue 3, 2008, Pages 384-391

  Yilmaz, Nafiye ^a,b   Pektas, Mine ^a   Tonguc, Esra ^a   Kilic, Sevtap ^a   Gulerman, Cavidan ^a   Gungor, Tayfun ^a   Mollamahmutoglu, Leyla ^a  

^a ZEKAI TAHIR BURAK WOMEN S HEALTH EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b NONE   (Turkey)

Author keywords

Homocysteine; Infertility; Insulin resistance; Metabolic syndrome; Polycystic ovary syndrome

Indexed keywords

HOMOCYSTEINE;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FEMALE INFERTILITY; GLUCOSE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FASTING; FEMALE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INFERTILITY, FEMALE; INSULIN; INSULIN RESISTANCE; POLYCYSTIC OVARY SYNDROME; TURKEY;

EID: 45149112186     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/j.1447-0756.2007.00699.x     Document Type: Article

References (32)

1. Welch GN. Homocysteine and atherothrombosis. N Engl J Med 1998 338 : 1042 1050.
2. Giltay EJ, Hoogeveen EK, Elbers JM, Gooren LJ, Asscheman H, Stehouwer CD. Effects of sex steroids on plasma total homocysteine levels: a study in transsexual males and females. J Clin Endocrinol Metab 1998 83 : 550 553.
3. Van Baal WM, Smolders RG, van der Mooren MJ, Teerlink T, Kenemans P. Hormone replacement therapy and plasma homocysteine levels. Obstet Gynecol 1999 94 : 485 491.
4. McCarty MF. Increased homocysteine associated with smoking, chronic inflammation, and aging may reflect acute-phase induction of pyridoxal phosphatase activity. Med Hypotheses 2000 55 : 289 293.
5. Nygard O, Refsum H, Ueland PM, Vollset SE. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 1998 67 : 263 270.
6. Schneede J, Refsum H, Ueland PM. Biological and environmental determinants of plasma homocysteine. Semin Thromb Hemost 2000 26 : 273 279.
7. McCarty MF. Insulin secretion as a potential determinant of homocysteine levels. Med Hypotheses 2000 55 : 454 455.
8. Meigs JB, Jacques PF, Selhub J et al. Fasting plasma homocysteine levels in the insulin resistance syndrome. Diabetes Care 2001 1403 1410.
9. McFarlane SI, Banjeri M, Sowers JR. Insulin resistance and cardiovascular disease. J Clin Endocrinol Metab 2001 86 : 713 718.
10. Sheu WH, Lee WJ, Chen YT. Plasma homocysteine concentration and insulin sensitivity in hypertensive subjects. Am J Hypertens 2000 13 : 14 20.
11. Gennarelli G, Holte J, Berglund L, Berne C, Massobrio M, Lithell H. Prediction models for insulin resistance in the polycystic ovary syndrome. Hum Reprod 2000 15 : 2098 2102.
12. Iuorno MJ, Nestler JE. Insulin-lowering drugs in polycystic ovary syndrome. Obstet Gynecol Clin North Am 2001 28 : 153 164.
13. Dahlgren E, Janson PO. Long-term health implications for women with polycystic ovary syndrome. In : Kovacs GT (ed.). Polycystic Ovary Syndrome. Cambridge : Cambridge University Press, 2000 70 79.
14. Loverro G, Lorusso F, Mei L, Depalo R, Cormio G. The plasma homocysteine levels are increased in polycystic ovary syndrome. Gynecol Obstet Invest 2002 53 : 157 162.
15. Schachter M, Raziel A, Friedler S, Strassburger D, Bern O, Ron-El R. Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Hum Reprod 2003 18 : 721 727.
16. Goldstein BJ, Haffner SM, Hsueh WA. Insulin Resistance Implications for Metabolic and Cardiovascular Diseases. CME Circle-Diabetes and Endocrinology Continuing Medical Education Online. 2001. Available from URL: http://www.medscape.com/CMECircle/Diabetes/2001
17. Trivax B, Azziz R. Diagnosis of polycystic ovary syndrome. Clin Obstet Gynecol 2007 50 : 168 177.
18. Matthews DR, Hosker JP, Rudenski A, Turner RC. Homeostasis model assessment: insulin resistance and beta cell function in man. Diabeteologia 1985 28 : 401 411.
19. Quere L, Mercier E, Bellet H, Janbon C, Mares P, Gris JC. Vitamin supplementation and pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia. Fertil Steril 2001 75 : 823 825.
20. Diamanti-Kandarakis E, Spina G, Kouli C, Migdalis I. Increased endothelin levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy. J Clin Endocrinol Metab 2001 86 : 4666 4673.
21. Nelen WL, Blom HJ, Steegers EAP, den Heijer M, Eskes TKAB. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil Steril 2000 74 : 1196 1199.
22. Dunaif A. Insulin resistance and polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997 18 : 774 800.
23. Giltay EJ, Hoogeveen EK, Elbers JM, Gooren LJ, Asscheman H, Stehouwer CD. Insulin resistance is associated with elevated plasma total homocysteine levels in healthy, non-obese subjects. Atherosclerosis 1998 139 : 197 198.
24. Sills ES, Genton MG, Perloe M, Schattman GL, Bralley JA, Tucker MJ. Plasma homocysteine, fasting insulin, and androgen patterns among women with polycystic ovaries and infertility. J Obstet Gynecol Res 2001 27 : 163 168.
25. Meigs JB, Jacques PF, Selhub J et al. Fasting plasma homocysteine levels in the insulin resistance syndrome. Diabetes Care 2001 24 : 1403 1410.
26. Badawy A, State O, Gawad S, Aziz O. Plasma homocysteine and polycystic ovary syndrome: the missed link. Eur J Obstet Gynecol 2006 51 : 65 69.
27. Yarali H, Yildirir A, Aybar F et al. Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome. Fertil Steril 2002 76 : 511 516.
28. Bayraktar F, Dereli D, Ozgen G, Yilmaz C. Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia. Endocr J 2004 51 : 601 608.
29. Kilic-Okman T, Guldiken S, Kucuk M. Relationship between homocysteine and insulin resistance in women with polycystic ovary syndrome. Endocr J 2004 51 : 505 508.
30. Yilmaz M, Biri A, Bukan N et al. Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome. Gynecol Endocr 2005 20 : 258 263.
31. Wijeyaratne C, Nirantharakumar K, Balen A, Barth J, Sheriff R, Belchetz P. Plasma homocysteine in polycystic ovary syndrome: does it correlate with insulin resistance and ethnicity? Clin Endocrinol 2004 60 : 560 567.
32. Li Y, Cheng J, Zhu WL, Dao JJ, Yan LY, Li MY. Study of serum Hcy and polymorphisms of Hcy metabolic enzymes in 192 families affected by congenital heart disease. Beijing Da Xue Xue Bao 2005 37 : 75 80.