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Volumn 29, Issue 7, 2015, Pages 330-339

Crocin Abrogates Carbon Tetrachloride-Induced Renal Toxicity in Rats via Modulation of Metabolizing Enzymes and Diminution of Oxidative Stress, Apoptosis, and Inflammatory Cytokines

Author keywords

Antioxidants; Carbon Tetrachloride; Crocin; Metabolizing Enzymes; Oxidative Stress

Indexed keywords

CARBON TETRACHLORIDE; CASPASE 3; CATALASE; CORN OIL; CREATININE; CROCIN; CYTOCHROME P450 2E1; CYTOKINE; ENZYME; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; INTERLEUKIN 6; LIPID PEROXIDE; MALONALDEHYDE; PROSTAGLANDIN E2; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; URIC ACID; CAROTENOID; PROTECTIVE AGENT;

EID: 84935744968     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.21702     Document Type: Article
Times cited : (21)

References (48)
  • 4
    • 0042123515 scopus 로고    scopus 로고
    • Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats
    • Ozturk F, Ucar M, Ozturk IC, Vardi N, Batcioglu K. Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats. Urology 2003;62(2):353-356.
    • (2003) Urology , vol.62 , Issue.2 , pp. 353-356
    • Ozturk, F.1    Ucar, M.2    Ozturk, I.C.3    Vardi, N.4    Batcioglu, K.5
  • 5
    • 0038583217 scopus 로고    scopus 로고
    • Carbon tetrachloride
    • Geneva: WHO
    • International Programme on Chemical Safety (IPCS). Carbon tetrachloride. Environmental health criteria 208. Geneva: WHO; 1999.
    • (1999) Environmental health criteria 208
  • 6
    • 0003615543 scopus 로고    scopus 로고
    • Toxicological profile for carbon tetrachloride
    • Atlanta, GA: U.S. Department of Health and Human Services
    • Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for carbon tetrachloride. Atlanta, GA: U.S. Department of Health and Human Services. 2005.
    • (2005)
  • 7
    • 84861548350 scopus 로고    scopus 로고
    • Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats
    • Hassan MH, Edfawy M, Mansour A, Hamed AA. Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats. Toxicol Ind Health 2012;28(5):428-438
    • (2012) Toxicol Ind Health , vol.28 , Issue.5 , pp. 428-438
    • Hassan, M.H.1    Edfawy, M.2    Mansour, A.3    Hamed, A.A.4
  • 8
    • 0034056796 scopus 로고    scopus 로고
    • Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney
    • Cummings BS, Lasker JM, Lash LH. Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney. J Pharmacol Exp Ther 2000;293:677-685.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 677-685
    • Cummings, B.S.1    Lasker, J.M.2    Lash, L.H.3
  • 9
    • 0034654333 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes
    • Zangar RC, Benson JM, Burnett VL, Springer DL. Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes. Chem Biol Interact 2000;125(3):233-243.
    • (2000) Chem Biol Interact , vol.125 , Issue.3 , pp. 233-243
    • Zangar, R.C.1    Benson, J.M.2    Burnett, V.L.3    Springer, D.L.4
  • 11
    • 84899852455 scopus 로고    scopus 로고
    • Protective effects of crocin on ischemia-reperfusion induced oxidative stress in comparison with vitamin E in isolated rat hearts
    • Dianat M, Esmaeilizadeh M, Badavi M, Samarbaf-Zadeh AR, Naghizadeh B. Protective effects of crocin on ischemia-reperfusion induced oxidative stress in comparison with vitamin E in isolated rat hearts. J Nat Pharm Prod 2014;9(2):e17187.
    • (2014) J Nat Pharm Prod , vol.9 , Issue.2 , pp. e17187
    • Dianat, M.1    Esmaeilizadeh, M.2    Badavi, M.3    Samarbaf-Zadeh, A.R.4    Naghizadeh, B.5
  • 12
    • 84904721165 scopus 로고    scopus 로고
    • Crocin attenuates cisplatin-induced liver injury in the mice
    • Sun Y, Yang J, Wang LZ, Sun LR, Dong Q. Crocin attenuates cisplatin-induced liver injury in the mice. Hum Exp Toxicol 2013;33(8):855-862.
    • (2013) Hum Exp Toxicol , vol.33 , Issue.8 , pp. 855-862
    • Sun, Y.1    Yang, J.2    Wang, L.Z.3    Sun, L.R.4    Dong, Q.5
  • 13
    • 27744563733 scopus 로고    scopus 로고
    • Antihyperlipidemic effect of crocin isolated from the fractus of Gardenia jasminoides and its metabolite crocetin
    • Lee IAH, Lee JH, Baek NI, Kim DH. Antihyperlipidemic effect of crocin isolated from the fractus of Gardenia jasminoides and its metabolite crocetin. Biol Pharm Bull 2005;28(11):2106-2110.
    • (2005) Biol Pharm Bull , vol.28 , Issue.11 , pp. 2106-2110
    • Lee, I.A.H.1    Lee, J.H.2    Baek, N.I.3    Kim, D.H.4
  • 14
    • 20444445184 scopus 로고    scopus 로고
    • Effects of crocin on experimental atherosclerosis in quails and its mechanisms
    • He SHY, Qian ZY, Tang FT, Wen N, Xu GL, Sheng L. Effects of crocin on experimental atherosclerosis in quails and its mechanisms. Life Sci. 2005;77(8):907-921.
    • (2005) Life Sci , vol.77 , Issue.8 , pp. 907-921
    • He, S.H.Y.1    Qian, Z.Y.2    Tang, F.T.3    Wen, N.4    Xu, G.L.5    Sheng, L.6
  • 15
    • 77952317000 scopus 로고    scopus 로고
    • Crocin from Kashmiri saffron (Crocus sativus) induces in vitro and in vivo xenograft growth inhibition of Dalton's lymphoma
    • Bakshi H, Sam S, Feroz A, Ravesh Z, Shah GA, Sharma M. Crocin from Kashmiri saffron (Crocus sativus) induces in vitro and in vivo xenograft growth inhibition of Dalton's lymphoma. Asian Pac J Cancer Prev 2009;10(5):887-890.
    • (2009) Asian Pac J Cancer Prev , vol.10 , Issue.5 , pp. 887-890
    • Bakshi, H.1    Sam, S.2    Feroz, A.3    Ravesh, Z.4    Shah, G.A.5    Sharma, M.6
  • 16
    • 78650715139 scopus 로고    scopus 로고
    • DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from kashmiri saffron in a human pancreatic cancer cell line
    • Bakshi H, Sam S, Rozati R, Sultan P, Islam T, Rathore B, Lone Z, Sharma M, Triphati J, Saxena RC. DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from kashmiri saffron in a human pancreatic cancer cell line. Asian Pac J Cancer Prev 2010;11(3):675-679.
    • (2010) Asian Pac J Cancer Prev , vol.11 , Issue.3 , pp. 675-679
    • Bakshi, H.1    Sam, S.2    Rozati, R.3    Sultan, P.4    Islam, T.5    Rathore, B.6    Lone, Z.7    Sharma, M.8    Triphati, J.9    Saxena, R.C.10
  • 17
    • 77952881985 scopus 로고    scopus 로고
    • Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats
    • Asdaq SM, Inamdar MN. Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Appl Biochem Biotechnol 2010;162(2):358-372.
    • (2010) Appl Biochem Biotechnol , vol.162 , Issue.2 , pp. 358-372
    • Asdaq, S.M.1    Inamdar, M.N.2
  • 18
    • 84864112551 scopus 로고    scopus 로고
    • Crocin saffron protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes
    • El-Beshbishy HA, Hassan MH, Aly HA, Doghish AS, Alghaithy AA. Crocin saffron protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. Ecotoxicol Environ Saf 2012;83:47-54
    • (2012) Ecotoxicol Environ Saf , vol.83 , pp. 47-54
    • El-Beshbishy, H.A.1    Hassan, M.H.2    Aly, H.A.3    Doghish, A.S.4    Alghaithy, A.A.5
  • 19
    • 77956345099 scopus 로고    scopus 로고
    • Crocin attenuates cisplatin-induced renal oxidative stress in rats
    • Naghizadeh B, Mansouri SM, Mashhadian NV. Crocin attenuates cisplatin-induced renal oxidative stress in rats. Food Chem Toxicol 2010;48(10):2650-2655.
    • (2010) Food Chem Toxicol , vol.48 , Issue.10 , pp. 2650-2655
    • Naghizadeh, B.1    Mansouri, S.M.2    Mashhadian, N.V.3
  • 22
    • 0019142866 scopus 로고
    • Increase of NADPH, quinone reductase activity by dietary antioxidant: possible role in protection against carcinogenesis and toxicity
    • Benson AM, Hunkeler MJ, Talalay P. Increase of NADPH, quinone reductase activity by dietary antioxidant: possible role in protection against carcinogenesis and toxicity. Proc Nat Acad Sci USA 1980;77:5216-5220
    • (1980) Proc Nat Acad Sci USA , vol.77 , pp. 5216-5220
    • Benson, A.M.1    Hunkeler, M.J.2    Talalay, P.3
  • 23
    • 0642284630 scopus 로고    scopus 로고
    • Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation
    • Chang TK, Crespi CL, Waxman DJ. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. Methods Mol Biol 1998;107:147-152.
    • (1998) Methods Mol Biol , vol.107 , pp. 147-152
    • Chang, T.K.1    Crespi, C.L.2    Waxman, D.J.3
  • 24
    • 0016275313 scopus 로고
    • Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation
    • 7130e9
    • Habig WH, Pabst MJ, Jacob WB. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130e9.
    • (1974) J Biol Chem , vol.249
    • Habig, W.H.1    Pabst, M.J.2    Jacob, W.B.3
  • 25
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95(2):351-358.
    • (1979) Anal Biochem , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 26
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver
    • Moron MS, Despierre JW, Minnervik B. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979;582:67-78.
    • (1979) Biochim Biophys Acta , vol.582 , pp. 67-78
    • Moron, M.S.1    Despierre, J.W.2    Minnervik, B.3
  • 27
    • 77957010110 scopus 로고
    • Isolation of liver or kidney mitochondria
    • Johnson D, Lardy H. Isolation of liver or kidney mitochondria. Methods Enzymol 1967;10:94-96.
    • (1967) Methods Enzymol , vol.10 , pp. 94-96
    • Johnson, D.1    Lardy, H.2
  • 29
    • 0016272750 scopus 로고
    • Involvement of superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase
    • Marklund S, Marklund G. Involvement of superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469-744.
    • (1974) Eur J Biochem , vol.47 , pp. 469-744
    • Marklund, S.1    Marklund, G.2
  • 30
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitativ characterization of erythrocyte glutathione peroxidase
    • Paglia DE, Valentine WN. Studies on the quantitative and qualitativ characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70(1):158-169.
    • (1967) J Lab Clin Med , vol.70 , Issue.1 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 31
    • 0015353270 scopus 로고
    • Colorimetric assay of catalase
    • Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972;47(2):389-394.
    • (1972) Anal Biochem , vol.47 , Issue.2 , pp. 389-394
    • Sinha, A.K.1
  • 32
    • 8544251273 scopus 로고    scopus 로고
    • Gene therapy of uterine leiomyomas: adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice
    • Al-Hendy A, Lee EJ, Wang HQ, Copland JA. Gene therapy of uterine leiomyomas: adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice. Am J Obstet Gynecol 2004;191:1621-1631
    • (2004) Am J Obstet Gynecol , vol.191 , pp. 1621-1631
    • Al-Hendy, A.1    Lee, E.J.2    Wang, H.Q.3    Copland, J.A.4
  • 33
    • 0037436437 scopus 로고    scopus 로고
    • Role of oxidative stress and mitochondrial changes in cyanobacteria induced apoptosis and hepatotoxicity
    • Ding WX, Ong NC. Role of oxidative stress and mitochondrial changes in cyanobacteria induced apoptosis and hepatotoxicity. FEMS Microbiol Lett 2003;220:1-7.
    • (2003) FEMS Microbiol Lett , vol.220 , pp. 1-7
    • Ding, W.X.1    Ong, N.C.2
  • 34
    • 77956340469 scopus 로고    scopus 로고
    • Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal
    • Hariri AT, Moallem SA, Mahmoudi M, Memar B, Hosseinzadeh H. Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal. Food Chem Toxicol 2010;48(10):2803-2808
    • (2010) Food Chem Toxicol , vol.48 , Issue.10 , pp. 2803-2808
    • Hariri, A.T.1    Moallem, S.A.2    Mahmoudi, M.3    Memar, B.4    Hosseinzadeh, H.5
  • 35
    • 79952334139 scopus 로고    scopus 로고
    • Dietary diacetylene falcarindiol induces phase 2 drug-metabolizing enzymes and blocks carbon tetrachloride-induced hepatotoxicity in mice through suppression of lipid peroxidation
    • Ohnuma T, Anan E, Hoashi R, Takeda Y, Nishiyama T, Ogura K, Hiratsuka A. Dietary diacetylene falcarindiol induces phase 2 drug-metabolizing enzymes and blocks carbon tetrachloride-induced hepatotoxicity in mice through suppression of lipid peroxidation. Biol Pharm Bull 2011;34(3):371-378.
    • (2011) Biol Pharm Bull , vol.34 , Issue.3 , pp. 371-378
    • Ohnuma, T.1    Anan, E.2    Hoashi, R.3    Takeda, Y.4    Nishiyama, T.5    Ogura, K.6    Hiratsuka, A.7
  • 36
    • 35649020801 scopus 로고    scopus 로고
    • Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity
    • Hwang YP, Choi CY, Chung YC, Jeon SS, Jeong HG. Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. Arch Pharm Res 2007;30(10):1309-1317.
    • (2007) Arch Pharm Res , vol.30 , Issue.10 , pp. 1309-1317
    • Hwang, Y.P.1    Choi, C.Y.2    Chung, Y.C.3    Jeon, S.S.4    Jeong, H.G.5
  • 37
    • 0025126555 scopus 로고
    • Role of free radicals and catalytic metal ions in human disease: an overview
    • Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 1990;186:1-85.
    • (1990) Methods Enzymol , vol.186 , pp. 1-85
    • Halliwell, B.1    Gutteridge, J.M.2
  • 39
    • 26844522332 scopus 로고    scopus 로고
    • Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF- B activity in lipopolysaccharide-activated human primary monocytes
    • Lu Y, Wahl LM. Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF- B activity in lipopolysaccharide-activated human primary monocytes. J Immunol 2005;175:5423.
    • (2005) J Immunol , vol.175 , pp. 5423
    • Lu, Y.1    Wahl, L.M.2
  • 42
    • 0029891611 scopus 로고    scopus 로고
    • Prolongation of survival and antitumor activity of antitumor drugs in murine cancer cachexia model
    • Nukatsuka M, Fujioka A, Saito H, Uchida J, Takeda S, Unemi N. Prolongation of survival and antitumor activity of antitumor drugs in murine cancer cachexia model. Gan To Kagaku Ryoho 1996;23(7):887-892.
    • (1996) Gan To Kagaku Ryoho , vol.23 , Issue.7 , pp. 887-892
    • Nukatsuka, M.1    Fujioka, A.2    Saito, H.3    Uchida, J.4    Takeda, S.5    Unemi, N.6
  • 43
    • 0029893140 scopus 로고    scopus 로고
    • Role of interleukin-6 in macrophage function
    • Akira S, Kishimoto T. Role of interleukin-6 in macrophage function. Curr Opin Hematol 1996;3:87-93.
    • (1996) Curr Opin Hematol , vol.3 , pp. 87-93
    • Akira, S.1    Kishimoto, T.2
  • 44
    • 79958811218 scopus 로고    scopus 로고
    • Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome
    • Sauter KA, Wood LJ, Wong J, Iordanov M, Magun BE. Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome. Cancer Biol Ther 2011;11(12):1008-1016.
    • (2011) Cancer Biol Ther , vol.11 , Issue.12 , pp. 1008-1016
    • Sauter, K.A.1    Wood, L.J.2    Wong, J.3    Iordanov, M.4    Magun, B.E.5
  • 45
    • 0035798068 scopus 로고    scopus 로고
    • Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells
    • Soeda S, Ochiai T, Paopong L, Tanaka H, Shoyama Y, Shimeno H. Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells. Life Sci 2001;69(24):2887-2898.
    • (2001) Life Sci , vol.69 , Issue.24 , pp. 2887-2898
    • Soeda, S.1    Ochiai, T.2    Paopong, L.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 46
    • 77955277971 scopus 로고    scopus 로고
    • Recombinant human interleukin-1 receptor antagonist protects mice against acute doxorubicin-induced cardiotoxicity
    • Zhu J, Zhang J, Xiang D, Zhang Z, Zhang L, Wu M, Zhu S, Zhang R, Han W. Recombinant human interleukin-1 receptor antagonist protects mice against acute doxorubicin-induced cardiotoxicity. Eur J Pharmacol 2010;643:247-253.
    • (2010) Eur J Pharmacol , vol.643 , pp. 247-253
    • Zhu, J.1    Zhang, J.2    Xiang, D.3    Zhang, Z.4    Zhang, L.5    Wu, M.6    Zhu, S.7    Zhang, R.8    Han, W.9
  • 48
    • 39049176405 scopus 로고    scopus 로고
    • Crocetin inhibits mRNA expression for tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in hemorrhagic shock. JPEN
    • Yang R, Tan X, Thomas AM, Shen J, Qureshi, N., Morrison DC, VanWay CW 3rd. Crocetin inhibits mRNA expression for tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in hemorrhagic shock. JPEN. J Parenter Enteral Nutr 2006;30(4):297-301.
    • (2006) J Parenter Enteral Nutr , vol.30 , Issue.4 , pp. 297-301
    • Yang, R.1    Tan, X.2    Thomas, A.M.3    Shen, J.4    Qureshi, N.5    Morrison, D.C.6    Van Way, C.W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.